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Background: Alcohol use is a key preventable risk factor for serious injury. To effectively prevent alcohol-related injuries, we rely on the accurate surveillance of alcohol involvement in injury events. This often involves the use of administrative data, such as International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification (ICD-10-AM) coding. Objective: To evaluate the completeness and accuracy of using administrative coding for the surveillance of alcohol involvement in major trauma injury events by comparing patient blood alcohol concentration (BAC) with ICD-10-AM coding. Method: This retrospective cohort study examined 2918 injury patients aged ≥18 years who presented to a major trauma centre in Victoria, Australia, over a 2-year period, of which 78% ( n = 2286) had BAC data available. Results: While 15% of patients had a non-zero BAC, only 4% had an ICD-10-AM code suggesting acute alcohol involvement. The agreement between blood alcohol test results and ICD-10-AM coding of acute alcohol involvement was fair ( κ = 0.33, 95% confidence interval: 0.27–0.38). Of the 341 patients with a non-zero BAC, 82 (24.0%) had ICD-10-AM codes related to acute alcohol involvement. Supplementary factors Y90 Evidence of alcohol involvement determined by blood alcohol level codes, which specifically describe patient BAC, were assigned to just 29% of eligible patients with a non-zero BAC. Conclusion: ICD-10-AM coding underestimated the proportion of alcohol-related injuries compared to patient BAC. Implications: Given the current role of administrative data in the surveillance of alcohol-related injuries, these findings may have significant implications for the implementation of cost-effective strategies for preventing alcohol-related injuries.

The ocean provides resources key to human health and well-being, including food, oxygen, livelihoods, blue spaces, and medicines. The global threat to these resources posed by accelerating ocean acidification is becoming increasingly evident as the world’s oceans absorb carbon dioxide emissions. While ocean acidification was initially perceived as a threat only to the marine realm, here we argue that it is also an emerging human health issue. Specifically, we explore how ocean acidification affects the quantity and quality of resources key to human health and well-being in the context of: (1) malnutrition and poisoning, (2) respiratory issues, (3) mental health impacts, and (4) development of medical resources. We explore mitigation and adaptation management strategies that can be implemented to strengthen the capacity of acidifying oceans to continue providing human health benefits. Importantly, we emphasize that the cost of such actions will be dependent upon the socioeconomic context; specifically, costs will likely be greater for socioeconomically disadvantaged populations, exacerbating the current inequitable distribution of environmental and human health challenges. Given the scale of ocean acidification impacts on human health and well-being, recognizing and researching these complexities may allow the adaptation of management such that not only are the harms to human health reduced but the benefits enhanced.

At the peak of the COVID-19 pandemic, the estimated daily use of face masks was at its highest, thereby creating huge public health and environmental challenges associated with the indiscriminate disposal of used ones. The present study assessed Abu Dhabi University students’ handling and disposal of single-use face masks during the pandemic. A cross-sectional study using an online survey questionnaire was used to gather data from 255 students from the target group. Face mask type was found to be significantly influenced by both the student’s gender and age, while the participant’s habit of hand washing after handling a used face mask was found to be significantly influenced by the student’s age. The student’s educational level significantly influenced group decisions regarding the most appropriate face mask to use, as well as environmental and health consequences awareness of indiscriminate face mask disposal. While the students are adequately aware of COVID-19’s impact and had good knowledge of face mask use, a high proportion professed to the unsafe disposal of used face masks in public areas, thereby adding to microplastic pollution in the environment and its associated impacts. The study alluded to the need for strengthening the participant’s knowledge, attitude, and practices as precautionary measures that mitigate the environmental effect of the indiscriminate disposal of used face masks. The findings also call for a collaborative partnership among stakeholders toward designing effective educational campaigns to minimize the environmental impacts posed by face mask disposal.

In battery systems, aqueous electrolytes are superior in ionic conductivity, interfacial wettability, safety and environmentally benign compared to organic liquids, polymers, inorganic solid-state and ionic liquid electrolytes.

A further investigation has been made of the experimental factors which control the rate of spreading of electrolyte films on partially immersed, negatively polarised metal substrates. These have included electrolyte concentration, conductivity and cation type. It is shown that the spreading rate is directly proportional to electrolyte conductivity and cation mobility. A critical consideration of these experimental factors, together with those determined in previous investigation, leads to the conclusion that neither the mechanism based on the Marangoni effect nor that based on classical electroosmosis are capable of explaining the observations in any conclusive manner. It is shown that an electromigration type model is more relevant. In this mechanism momentum is transferred to the solution at the intrinsic meniscus front or within the film by migrating cations involved in the electrolytic conduction process which is necessary to maintain continuity of current between the metal/film interface (hydrogen evolution and/or oxygen reduction reactions) and the film/bulk electrolyte region.

The use of traditional medicine has been growing rapidly lately. One of the medicinal plants that have been developed especially in East Kalimantan is Dayak onion plant (Eleutherinepalmifolia (L.) Merr). Dayak onion concoctions have also been used by various groups of Dayaks as an alternative medicine for various diseases, and also to find out the possibility of people who being affected by the disease and how to process Dayak onion ingredients, an disease diagnosis system is needed that is able to diagnose the disease and how to process Dayak onion ingredients to get proper treatment. This study uses ten diseases that can be diagnosed, namely Hemorrhoid Disease, Nephrolithiasis, Diabetes Mellitus, Hypertension, Hepatitis, Tuberculosis, Bronchitis, Sinusitis, Uric Acid, and Rheumatism. The method used is Certainty Factor; the result of this research is a web-based expert system that is used to assist people in diagnosing diseases that can be cured by Dayak Onion.

AbstractIssue. Scotland has experienced a substantial rise in alcohol‐related harm, which is now one of the biggest public health challenges it faces. Approach. Alcohol problems in Scotland are described along with national alcohol policy response in addressing them. The role of a program of Alcohol Brief Interventions is discussed therein. Key Findings. In Scotland, considerable proportions of the population are drinking hazardously or harmfully, common across different age and socioeconomic groups. Rising consumption has been set in wider environmental changes with alcohol becoming more available and affordable. Scotland has had one of the fastest growing chronic liver disease mortality rates in the world at a time when rates in most of Western Europe are falling. Scotland's alcohol policy has an explicit aim to reduce population consumption and includes legislative measures to tackle price and availability. A national program to deliver Alcohol Brief Interventions for hazardous drinkers is a key plank of this wider strategy. A portfolio of studies will monitor and evaluate national policy and, through contribution analysis, describe the role Alcohol Brief Interventions play in reducing alcohol misuse. Implications. Effective alcohol policy recognises that determinants of health not only lie at individual level, but include wider social, environmental and economic factors. Scotland's policy is addressing these determinants with both population‐based and population‐targeted interventions. Conclusion. Scotland has a serious problem with alcohol. A comprehensive, evidence‐based, resourced alcohol policy is being implemented, which will need continual review to ensure it remains anchored in evidence while maintaining its ambition.[Graham LJC, MacKinnon D. Grasping the thistle: The role of alcohol brief interventions in Scottish alcohol policy. Drug Alcohol Rev 2010;29;603–607]

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest tumors, partly due to its intrinsic aggressiveness, metastatic potential, and chemoresistance of the contained cancer stem cells (CSCs). Pancreatic CSCs strongly rely on mitochondrial metabolism to maintain their stemness, therefore representing a putative target for their elimination. Since mitochondrial homeostasis depends on the tightly controlled balance between fusion and fission processes, namely mitochondrial dynamics, we aim to study this mechanism in the context of stemness. In human PDAC tissues, the mitochondrial fission gene DNM1L (DRP1) was overexpressed and positively correlated with the stemness signature. Moreover, we observe that primary human CSCs display smaller mitochondria and a higher DRP1/MFN2 expression ratio, indicating the activation of the mitochondrial fission. Interestingly, treatment with the DRP1 inhibitor mDivi-1 induced dose-dependent apoptosis, especially in CD133+ CSCs, due to the accumulation of dysfunctional mitochondria and the subsequent energy crisis in this subpopulation. Mechanistically, mDivi-1 inhibited stemness-related features, such as self-renewal, tumorigenicity, and invasiveness and chemosensitized the cells to the cytotoxic effects of Gemcitabine. In summary, mitochondrial fission is an essential process for pancreatic CSCs and represents an attractive target for designing novel multimodal treatments that will more efficiently eliminate cells with high tumorigenic potential.