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description Publicationkeyboard_double_arrow_right Article , Journal 2008Publisher:Elsevier BV Boris Orel; Vasko Jovanovski; A. Šurca Vuk; Ivan Jerman; A. Pollet-Villard;Abstract Novel proton-conducting electrolytes were prepared from the sol–gel precursor 1-[3-(trimethoxy-λ4-silyl)propyl]imidazole with the addition of either trifluoroacetic or acetic acid. The presence of trimethoxysilyl groups enabled the solvolysis and condensation reactions of silsesquioxane species. IR spectroscopy revealed that more cube-like species formed in the electrolyte prepared from trifluoroacetic acid, while cube- and ladder-like silsesquioxanes were present in the electrolyte with acetic acid. This assignation was independently confirmed by 29Si NMR analyses revealing the T3 signals of trisiloxane bonding. IR spectroscopy also pointed to the formation of hydrogen bonding in the latter electrolyte, since the frequencies of the observed bands at 1710, 1409, and 1272 cm−1 approached those of acetic acid. In contrast, the IR bands at 1662, 1204, and 1130 cm−1 confirmed the existence of trifluoroacetate anions in the case when the electrolyte was prepared from trifluoroacetic acid. The presence of free trifluoroacetate anions contributed to the moderately higher specific conductivity of this electrolyte (4.6×10−5 S/cm) compared to that of acetic acid (1.6×10−5 S/cm). The specific conductivity of the electrolytes could be further increased by the addition of a lithium salt. All electrolytes were employed in electrochromic devices with optically active WO3 and various inorganic counter-electrodes (CeVO4, V2O5, Ti/V-oxide). Photopic transmittance changes from 30% to 40% were achieved.
Solar Energy Materia... arrow_drop_down Solar Energy Materials and Solar CellsArticle . 2008 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.solmat.2007.01.023&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 49 citations 49 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Solar Energy Materia... arrow_drop_down Solar Energy Materials and Solar CellsArticle . 2008 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.solmat.2007.01.023&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2017Publisher:Springer Science and Business Media LLC Authors: Darjan Andrejc; Alenka Možir; Matic Legiša;At first glance, there appears to be a high degree of similarity between the metabolism of yeast (the Crabtree effect) and human cancer cells (the Warburg effect). At the root of both effects is accelerated metabolic flow through glycolysis which leads to overflows of ethanol and lactic acid, respectively. It has been proposed that enhanced glycolytic flow in cancer cells is triggered by the altered kinetic characteristics of the key glycolytic regulatory enzyme 6-phosphofructo-1-kinase (Pfk). Through a posttranslational modification, highly active shorter Pfk-M fragments, which are resistant to feedback inhibition, are formed after the proteolytic cleavage of the C-terminus of the native human Pfk-M. Alternatively, enhanced glycolysis is triggered by optimal growth conditions in the yeast Saccharomyces cerevisiae.To assess the deregulation of glycolysis in yeast cells, the sfPFKM gene encoding highly active human shorter Pfk-M fragments was introduced into pfk-null S. cerevisiae. No growth of the transformants with the sfPFKM gene was observed on glucose and fructose. Glucose even induced rapid deactivation of Pfk1 activities in such transformants. However, Pfk1 activities of the sfPFKM transformants were detected in maltose medium, but the growth in maltose was possible only after the addition of 10 mM of ethanol to the medium. Ethanol seemed to alleviate the severely unbalanced NADH/NADPH ratio in the sfPFKM cells. However, the transformants carrying modified Pfk-M enzymes grew faster than the transformants with the human native human Pfk-M enzyme in a narrow ecological niche with a low maltose concentration medium that was further improved by additional modifications. Interestingly, periodic extracellular accumulation of phenylacetaldehyde was detected during the growth of the strain with modified Pfk-M but not with the strain encoding the human native enzyme.Highly active cancer-specific shorter Pfk-M fragments appear to trigger several controlling mechanisms in the primary metabolism of yeast S. cerevisiae cells. These results suggest more complex metabolic regulation is present in S. cerevisiae as free living unicellular eukaryotic organisms in comparison to metazoan human cells. However, increased productivity under broader growth conditions may be achieved if more gene engineering is performed to reduce or omit several controlling mechanisms.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12896-017-0362-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12896-017-0362-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2011Publisher:Oxford University Press (OUP) Irwin Nazareth; Antonia Ridolfi; Miguel Xavier; Mirijam Geerlings; Juan Ángel Bellón; Anu Aluoja; Carl Walker; Michael King; Igor Švab;We examined the prevalence of heavy episodic drinking in general practice attenders who were non-hazardous drinkers, the associated risk factors and the outcome over 6 months.Consecutive attenders aged 18-75 were recruited from the UK, Spain, Slovenia, Estonia, the Netherlands and Portugal and followed up after 6 months. Data were collected on alcohol use using the Alcohol Use Disorder Identification test (at recruitment and 6 months) and risk factors for heavy episodic alcohol use at recruitment.The prevalence of heavy episodic drinking in non-hazardous drinkers was 4.5% across Europe [lowest in Portugal (1.5%); highest Netherlands (8.4%)]. It was less frequent in Spain, Slovenia, Estonia and Portugal compared with the UK and Netherlands. It was higher in men [odd ratio (OR) 4.4, 95% confidence interval (CI) 3.3, 5.9], people between 18 and 29 years of age, those employed (OR 1.8, 95% CI 1.3, 2.6) and those using recreational drugs (OR 2.1, 95% CI 1.4, 3.3). It was lower in people with existing DSMIV major depression (OR 0.54, 95% CI 0.31, 0.96). Heavy episodic drinkers were more likely to become hazardous drinkers at 6 months (male: OR 7.2, 95% CI 4.1, 12.7; female: OR 9.4, 95% CI 4.3, 20.6).Women and men in the UK, men in the Netherlands and younger people in all countries are at the greatest risk of exhibiting heavy episodic drinking behaviours even in the absence of hazardous alcohol use. There is hence an urgent need for general practitioners to consider early detection and management of heavy episodic drinking behaviour in this population.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/alcalc/agr078&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 23 citations 23 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/alcalc/agr078&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Report 2023Publisher:Zenodo Kolar, Jana; Brečko, Barbara; Campana, Pierluigi; Chamberlain, Martyn; Daillant, Jean; Harrison, Andrew; Keppler, Antje; Lévai, Péter; Martins, René; Plaskan, Jure; Weeks, Allen; Wosnitza, Joachim;In conjunction with the COVID-19 pandemic aftermath, Russian aggression on Ukraine has wide-ranging consequences for the EU, including high inflation, an immense energy cost increase, and a shortage of critical resources. All of these have pronounced effects on the sustainability and operations of research infrastructures (RIs), several of which face difficulties in providing continuous service. To address these topics, the European Strategy Forum on Research Infrastructures (ESFRI) has established a dedicated drafting group to look into the energy and supply challenges, also responding to a call by Competitiveness Council to do so. This report highlights the significant impact of the Russian aggression on Ukraine on the sustainability and operations of research infrastructures (RIs) in the EU. The energy crisis resulting from the Russian aggression poses a severe challenge to the RIs, predominantly analytical RIs, with energy-intensive RIs such as synchrotrons, computing centres, accelerator-driven particle sources, neutron facilities, research reactors, and lasers being the most affected. The shortage of critical resources and materials, such as some gases, rare isotopes, and permanent magnets, also presents a significant challenge to RIs, although they may not be a consequence of the war. The report presents recommendations to ESFRI, Member States, and the European Commission based on good practices from ESFRI member countries and the discussion within the drafting group to address these challenges and enhance the future resilience of RIs. The recommendations include allocating additional funds and energy price capping for the most energy-intensive RIs, developing response plans that include actions aimed at greening the operations of RIs, considering the needs of the RI communities in the activities linked to the Critical Raw Materials Regulation, and setting up specific measures to support the Ukrainian research community. The report emphasizes the importance of preparing for future crises, increasing the resilience and preparedness of European society to cope with any present and future crisis.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.8123921&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
visibility 351visibility views 351 download downloads 276 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.8123921&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2020 CroatiaPublisher:MDPI AG Funded by:HRZZ | Design and Synthesis of N...HRZZ| Design and Synthesis of Novel Nitrogen-Containing Heterocyclic Fluorophores and Fluorescent Nanomaterials for pH and Metal-Ion SensingTana Tandarić; Alja Prah; Jernej Stare; Janez Mavri; Robert Vianello;Monoamine oxidases (MAOs) catalyze the degradation of a very broad range of biogenic and dietary amines including many neurotransmitters in the brain, whose imbalance is extensively linked with the biochemical pathology of various neurological disorders, and are, accordingly, used as primary pharmacological targets to treat these debilitating cognitive diseases. Still, despite this practical significance, the precise molecular mechanism underlying the irreversible MAO inhibition with clinically used propargylamine inhibitors rasagiline and selegiline is still not unambiguously determined, which hinders the rational design of improved inhibitors devoid of side effects current drugs are experiencing. To address this challenge, we present empirical valence bond QM/MM simulations of the rate-limiting step of the MAO inhibition involving the hydride anion transfer from the inhibitor α-carbon onto the N5 atom of the flavin adenin dinucleotide (FAD) cofactor. The proposed mechanism is strongly supported by the obtained free energy profiles, which confirm a higher reactivity of selegiline over rasagiline, while the calculated difference in the activation Gibbs energies of ΔΔG‡ = 3.1 kcal mol−1 is found to be in very good agreement with that from the measured literature kinact values that predict a 1.7 kcal mol−1 higher selegiline reactivity. Given the similarity with the hydride transfer mechanism during the MAO catalytic activity, these results verify that both rasagiline and selegiline are mechanism-based irreversible inhibitors and offer guidelines in designing new and improved inhibitors, which are all clinically employed in treating a variety of neuropsychiatric and neurodegenerative conditions.
Full-text Institutio... arrow_drop_down International Journal of Molecular SciencesArticle . 2020 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijms21176151&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 17 citations 17 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
visibility 89visibility views 89 download downloads 79 Powered bymore_vert Full-text Institutio... arrow_drop_down International Journal of Molecular SciencesArticle . 2020 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijms21176151&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022Publisher:MDPI AG Authors: Borjana Kremžar Jovanović; Maja Smrdu; Rok Holnthaner; Tanja Kajtna;doi: 10.3390/su14052705
There is conflicting evidence that sport plays a protective role in the development of psychopathological disorders and contributes to the sustainability of mental health. The aim of the present study was to determine the prevalence of mental disorders among elite Slovenian athletes. We were interested in the prevalence of depression, anxiety, suicide risk, substance abuse, and eating disorders among athletes of both sexes and among athletes of individual and team sports aged 18 years or older. A total of 97 elite athletes participated in the study. We used PAI and EDI-3 questionnaires, and the study also included a control group of 90 non-athletes, matched in gender and age to the target group of elite athletes. Testing was conducted in 2020 and 2021. The comparison between elite athletes and the normative group showed a similar expression of depressive and anxious symptomatology. The athletes have a more pronounced drive for thinness and are more expansive, self-confident, and confident of their abilities compared to the control group. A total of 14% of the athletes show self-confidence to the point of self-grandiosity. Male athletes are more likely to use alcohol and other psychoactive substances and are also more impulsive and risk-taking, while female athletes are at higher risk of developing eating disorders. The study suggests that the prevalence of mental disorders in elite athletes is as high as in the general population. There is an urgent need to sustainably ensure the psychological well-being of athletes.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/su14052705&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/su14052705&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2021 SloveniaPublisher:MDPI AG Authors: Stanislav Avsec; Vesna Ferk Savec;doi: 10.3390/su131810443
Teacher education for sustainable development (ESD) is faced with continuing unsustainability trends, which require deep and enduring social transformation. Transformative learning is a possible solution to facilitating reflection on the cognitive and socio-emotional processes underpinning students’ learning towards sustainability. The purpose of this paper is to investigate students’ perceptions of, and experiences with, technology-enhanced self-directed learning and design thinking as possible moderators of transformative learning in order to advance the concept and practice of teacher ESD. These perceptions and experiences are represented by 225 pedagogical and non-pedagogical students from the University of Ljubljana, asked to respond anonymously to three online questionnaires in May and June 2021. Findings indicate that strengthening the transformative aspect of ESD in pre-service teachers requires the consideration of critical reflection, self-awareness, risk propensity, holistic view and openness to diversity, and social support. Moreover, self-directed learning was found to be a moderator for transformative learning among pre-service science teachers, while design thinking was evenly developed among transformative learning for both low- and high-ability students, no matter the study programme. The conditioning factors and explanatory arguments for these results are also discussed.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/su131810443&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 13 citations 13 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/su131810443&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Research , Preprint , Journal 2021Embargo end date: 01 Jan 2021 Argentina, Germany, France, Argentina, Czech Republic, Czech RepublicPublisher:Springer Science and Business Media LLC Funded by:ANR | SUPER, NSF | Pierre Auger ProjectANR| SUPER ,NSF| Pierre Auger ProjectG. Medina-Tanco; J. Stasielak; G. Farrar; Trent D. Grubb; Sullivan Marafico; F. C. T. Barbato; Rodrigo Guedes Lang; P. Abreu; Kai Daumiller; Adriana Vásquez-Ramírez; E.E. Pereira Martins; E.E. Pereira Martins; S. Querchfeld; Andres Travaini; Juan Manuel González; V. Scherini; François Montanet; Jonathan Blazek; Eleonora Guido; Marcel Köpke; J. de Oliveira; D. Lo Presti; A. M. Botti; Juan Miguel Carceller; O. Martínez Bravo; Jacco Vink; L. Perrone; M. Risse; A. Parra; A. Saftoiu; A. Machado Payeras; H. Wilczyński; Gualberto Avila; J. R. T. de Mello Neto; A.L. Garcia Vegas; I. Allekotte; B. Tome; Marc Weber; Kathrin Bismark; Kathrin Bismark; A. Di Matteo; Lorenzo Cazon; C. Pérez Bertolli; C. Pérez Bertolli; Alina Nasr-Esfahani; Paolo Privitera; Miguel Mostafa; M. E. Bertaina; W. M. Namasaka; Fabio Convenga; C. J.W.P. Timmermans; Fabian Gobbi; Fernando Contreras; L. Valore; A. Streich; A. Streich; Giovanni Consolati; Karen S. Caballero-Mora; Q. Luce; Raul Sarmento; M. Schimassek; M. Schimassek; Esteban Roulet; A. Haungs; J. Pȩkala; Martin Vacula; Virginia Binet; Vladimir Lenok; Niklas Langner; Carlos Escobar; Antonella Castellina; M. R. Hampel; Nataliia Borodai; A. A. Nucita; N. Kunka; Marco Aglietta; M. Zavrtanik; A.C. Cobos Cerutti; J. Rautenberg; R. López; Clara Keiko Oliveira Watanabe; R. Squartini; Josina Schulte; J. Vicha; M. del Río; Florian Lukas Briechle; Maximilian Stadelmaier; Maximilian Stadelmaier; G. De Mauro; J. Kleinfeller; M. Platino; John Matthews; M. Wirtz; S. Petrera; Giovanni Mancarella; Jon Paul Lundquist; Humberto Ibarguen Salazar; Octavian Sima; L. Nožka; Rossella Caruso; G. C. Hill; Carla Taricco; Kevin-Druis Merenda; Juan Pablo Gongora; Antonio Condorelli; Pierre Billoir; Philipp Papenbreer; Lino Miramonti; G. Golup; Carlo Ventura; G. Parente; Denis Stanca; Felix Schlüter; Felix Schlüter; Peter Buchholz; B. Andrada; R. Alves Batista; Toshihiro Fujii; Toshihiro Fujii; H. Martinez; A. Insolia; G. Cataldi; Alan Coleman; Corinne Berat; Cristina Galea; Alina Mihaela Badescu; G. P. Guedes; L. Lu; Orazio Zapparrata; B. Wundheiler; A. Filipčič; Peter L. Biermann; A. Weindl; Maria-Teresa Dova; Marcus Niechciol; E. De Vito; Jan Ebr; Jonathan Biteau; Isabel Goos; Isabel Goos; Jonas Glombitza; Fridtjof Feldbusch; D. D. dos Santos; Jeffrey Brack; V. de Souza; Radomir Smida; H.O. Klages; Jörg R. Hörandel; Ladislav Chytka; A. C. Fauth; M. I. Micheletti; Ioana Caracas; Julien Manshanden; L. Zehrer; W. Rodrigues de Carvalho; Vincenzo Rizi; Martina Bohacova; Zoé Torrès; Thomas Hebbeker; Frank G. Schröder; Frank G. Schröder; Petr Hamal; Alena Bakalova; Günter Sigl; Lukáš Vaclavek; J. Ridky; F. Riehn; Tomáš Fodran; K. Mulrey; Miroslav Pech; Juan Carlos D'Olivo; D. Ravignani; E. Varela; Markus Roth; M. A. Leigui de Oliveira; Claudio Galelli; Antonio Bueno; Marco Giammarchi; M. Palatka; R. Sato; Roberto Mussa; Olivier Deligny; C. Hojvat; Fabrizia Canfora; Sara Martinelli; Sara Martinelli; L. M. Domingues Mendes; David Wittkowski; P.R. Araújo Ferreira; Max Büsken; Max Büsken; Thomas Bretz; S. J. De Jong; M. Unger; Carla Aramo; M. Kleifges; Daniela Mockler; Daniela Mockler; Marcos Cerda; Serguei Vorobiov;doi: 10.1140/epjc/s10052-021-09700-w , 10.48550/arxiv.2109.13400 , 10.18154/rwth-2021-12100 , 10.18154/rwth-2022-00047
arXiv: 2109.13400
handle: 2133/23683
doi: 10.1140/epjc/s10052-021-09700-w , 10.48550/arxiv.2109.13400 , 10.18154/rwth-2021-12100 , 10.18154/rwth-2022-00047
arXiv: 2109.13400
handle: 2133/23683
AbstractWe present a measurement of the cosmic-ray spectrum above 100 PeV using the part of the surface detector of the Pierre Auger Observatory that has a spacing of 750 m. An inflection of the spectrum is observed, confirming the presence of the so-called second-knee feature. The spectrum is then combined with that of the 1500 m array to produce a single measurement of the flux, linking this spectral feature with the three additional breaks at the highest energies. The combined spectrum, with an energy scale set calorimetrically via fluorescence telescopes and using a single detector type, results in the most statistically and systematically precise measurement of spectral breaks yet obtained. These measurements are critical for furthering our understanding of the highest energy cosmic rays.
RepHipUNR - Reposito... arrow_drop_down RepHipUNR - Repositorio Hipermedial de la Universidad Nacional de RosarioArticle . 2021License: CC BYData sources: Bielefeld Academic Search Engine (BASE)KITopen (Karlsruhe Institute of Technologie)Article . 2021License: CC BYData sources: Bielefeld Academic Search Engine (BASE)European Physical Journal C: Particles and FieldsArticle . 2021 . Peer-reviewedLicense: CC BYData sources: CrossrefRecolector de Ciencia Abierta, RECOLECTAArticle . 2021License: CC BYData sources: Recolector de Ciencia Abierta, RECOLECTARepository of the Czech Academy of SciencesArticle . 2021Data sources: Repository of the Czech Academy of SciencesMémoires en Sciences de l'Information et de la CommunicationPreprint . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1140/epjc/s10052-021-09700-w&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 58 citations 58 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert RepHipUNR - Reposito... arrow_drop_down RepHipUNR - Repositorio Hipermedial de la Universidad Nacional de RosarioArticle . 2021License: CC BYData sources: Bielefeld Academic Search Engine (BASE)KITopen (Karlsruhe Institute of Technologie)Article . 2021License: CC BYData sources: Bielefeld Academic Search Engine (BASE)European Physical Journal C: Particles and FieldsArticle . 2021 . Peer-reviewedLicense: CC BYData sources: CrossrefRecolector de Ciencia Abierta, RECOLECTAArticle . 2021License: CC BYData sources: Recolector de Ciencia Abierta, RECOLECTARepository of the Czech Academy of SciencesArticle . 2021Data sources: Repository of the Czech Academy of SciencesMémoires en Sciences de l'Information et de la CommunicationPreprint . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1140/epjc/s10052-021-09700-w&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Frontiers Media SA Authors: ZhaoHong Han; Gang Bao;One of the most fascinating, consequential, and far-reaching debates that have occurred in second language acquisition research concerns the Critical Period Hypothesis [1]. Although the hypothesis is generally accepted for first language acquisition, it has been hotly debated on theoretical, methodological, and practical grounds for second language acquisition, fueling studies reporting contradictory findings and setting off competing explanations. The central questions are: Are the observed age effects in ultimate attainment confined to a bounded period, and if they are, are they biologically determined or maturationally constrained? In this article, we take asui generis, interdisciplinary approach that leverages our understanding of second language acquisition and of physics laws of energy conservation and angular momentum conservation, mathematically deriving the age-attainment geometry. The theoretical lens, termed Energy Conservation Theory for Second Language Acquisition, provides a macroscopic perspective on the second language learning trajectory across the human lifespan.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fphy.2023.1142584&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fphy.2023.1142584&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016Publisher:Engineering Society of Corrosion Funded by:MESTD | Biodiversity as potential..., EC | AREAMESTD| Biodiversity as potential in ecoremediation technologies of degraded ecosystems ,EC| AREAIlić, Dora; Radić, Danka; Karličić, Vera; Jovičić-Petrović, Jelena; Kiković, Dragan; Lalević, Blažo; Raičević, Vera;Except of benefits for human population, several industrial activities have a negative consequences i.e. increasing of heavy metal content and changes in diversity of living organisms in environment. The aim of this work was to examinated the influence of high content of heavy metals on microbial diversity of soil. Researches was conducted at locations of former factory 'Rog' (Ljubljana, Republic of Slovenia), by taking of four samples of contaminated soil, while the control was uncontaminated soil sample. Determination of microbial diversity (abundance of bacteria, fungi and actinomycetes) was performed using the standard methodology. The results of research showed that abundance of microorganisms depends on location and presence/absence of contamination. In control treatment abundance of all examinated groups of microorganisms was higher compared with other samples. The bacterial number in contaminated samples was from 1.21 to 6.88x106 CFU/g, the number of fungi was from 1,08 to 30,30x103 CFU/g, while actinomycetes number from 302,15 to 381,82x103 CFU/g. In control treatment, bacterial number was 17,45x106 CFU/g, fungi number 54,02x103 CFU/g and actinomycetes number 481,91x103 CFU/g. These results confirms the importance of microbial diversity research on contaminated locations and potential applications of bioremediation technologies on locations of former factory 'Rog'.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5937/zasmat1603383i&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
visibility 32visibility views 32 download downloads 82 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article , Journal 2008Publisher:Elsevier BV Boris Orel; Vasko Jovanovski; A. Šurca Vuk; Ivan Jerman; A. Pollet-Villard;Abstract Novel proton-conducting electrolytes were prepared from the sol–gel precursor 1-[3-(trimethoxy-λ4-silyl)propyl]imidazole with the addition of either trifluoroacetic or acetic acid. The presence of trimethoxysilyl groups enabled the solvolysis and condensation reactions of silsesquioxane species. IR spectroscopy revealed that more cube-like species formed in the electrolyte prepared from trifluoroacetic acid, while cube- and ladder-like silsesquioxanes were present in the electrolyte with acetic acid. This assignation was independently confirmed by 29Si NMR analyses revealing the T3 signals of trisiloxane bonding. IR spectroscopy also pointed to the formation of hydrogen bonding in the latter electrolyte, since the frequencies of the observed bands at 1710, 1409, and 1272 cm−1 approached those of acetic acid. In contrast, the IR bands at 1662, 1204, and 1130 cm−1 confirmed the existence of trifluoroacetate anions in the case when the electrolyte was prepared from trifluoroacetic acid. The presence of free trifluoroacetate anions contributed to the moderately higher specific conductivity of this electrolyte (4.6×10−5 S/cm) compared to that of acetic acid (1.6×10−5 S/cm). The specific conductivity of the electrolytes could be further increased by the addition of a lithium salt. All electrolytes were employed in electrochromic devices with optically active WO3 and various inorganic counter-electrodes (CeVO4, V2O5, Ti/V-oxide). Photopic transmittance changes from 30% to 40% were achieved.
Solar Energy Materia... arrow_drop_down Solar Energy Materials and Solar CellsArticle . 2008 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.solmat.2007.01.023&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 49 citations 49 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Solar Energy Materia... arrow_drop_down Solar Energy Materials and Solar CellsArticle . 2008 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2017Publisher:Springer Science and Business Media LLC Authors: Darjan Andrejc; Alenka Možir; Matic Legiša;At first glance, there appears to be a high degree of similarity between the metabolism of yeast (the Crabtree effect) and human cancer cells (the Warburg effect). At the root of both effects is accelerated metabolic flow through glycolysis which leads to overflows of ethanol and lactic acid, respectively. It has been proposed that enhanced glycolytic flow in cancer cells is triggered by the altered kinetic characteristics of the key glycolytic regulatory enzyme 6-phosphofructo-1-kinase (Pfk). Through a posttranslational modification, highly active shorter Pfk-M fragments, which are resistant to feedback inhibition, are formed after the proteolytic cleavage of the C-terminus of the native human Pfk-M. Alternatively, enhanced glycolysis is triggered by optimal growth conditions in the yeast Saccharomyces cerevisiae.To assess the deregulation of glycolysis in yeast cells, the sfPFKM gene encoding highly active human shorter Pfk-M fragments was introduced into pfk-null S. cerevisiae. No growth of the transformants with the sfPFKM gene was observed on glucose and fructose. Glucose even induced rapid deactivation of Pfk1 activities in such transformants. However, Pfk1 activities of the sfPFKM transformants were detected in maltose medium, but the growth in maltose was possible only after the addition of 10 mM of ethanol to the medium. Ethanol seemed to alleviate the severely unbalanced NADH/NADPH ratio in the sfPFKM cells. However, the transformants carrying modified Pfk-M enzymes grew faster than the transformants with the human native human Pfk-M enzyme in a narrow ecological niche with a low maltose concentration medium that was further improved by additional modifications. Interestingly, periodic extracellular accumulation of phenylacetaldehyde was detected during the growth of the strain with modified Pfk-M but not with the strain encoding the human native enzyme.Highly active cancer-specific shorter Pfk-M fragments appear to trigger several controlling mechanisms in the primary metabolism of yeast S. cerevisiae cells. These results suggest more complex metabolic regulation is present in S. cerevisiae as free living unicellular eukaryotic organisms in comparison to metazoan human cells. However, increased productivity under broader growth conditions may be achieved if more gene engineering is performed to reduce or omit several controlling mechanisms.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12896-017-0362-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12896-017-0362-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2011Publisher:Oxford University Press (OUP) Irwin Nazareth; Antonia Ridolfi; Miguel Xavier; Mirijam Geerlings; Juan Ángel Bellón; Anu Aluoja; Carl Walker; Michael King; Igor Švab;We examined the prevalence of heavy episodic drinking in general practice attenders who were non-hazardous drinkers, the associated risk factors and the outcome over 6 months.Consecutive attenders aged 18-75 were recruited from the UK, Spain, Slovenia, Estonia, the Netherlands and Portugal and followed up after 6 months. Data were collected on alcohol use using the Alcohol Use Disorder Identification test (at recruitment and 6 months) and risk factors for heavy episodic alcohol use at recruitment.The prevalence of heavy episodic drinking in non-hazardous drinkers was 4.5% across Europe [lowest in Portugal (1.5%); highest Netherlands (8.4%)]. It was less frequent in Spain, Slovenia, Estonia and Portugal compared with the UK and Netherlands. It was higher in men [odd ratio (OR) 4.4, 95% confidence interval (CI) 3.3, 5.9], people between 18 and 29 years of age, those employed (OR 1.8, 95% CI 1.3, 2.6) and those using recreational drugs (OR 2.1, 95% CI 1.4, 3.3). It was lower in people with existing DSMIV major depression (OR 0.54, 95% CI 0.31, 0.96). Heavy episodic drinkers were more likely to become hazardous drinkers at 6 months (male: OR 7.2, 95% CI 4.1, 12.7; female: OR 9.4, 95% CI 4.3, 20.6).Women and men in the UK, men in the Netherlands and younger people in all countries are at the greatest risk of exhibiting heavy episodic drinking behaviours even in the absence of hazardous alcohol use. There is hence an urgent need for general practitioners to consider early detection and management of heavy episodic drinking behaviour in this population.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/alcalc/agr078&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 23 citations 23 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/alcalc/agr078&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Report 2023Publisher:Zenodo Kolar, Jana; Brečko, Barbara; Campana, Pierluigi; Chamberlain, Martyn; Daillant, Jean; Harrison, Andrew; Keppler, Antje; Lévai, Péter; Martins, René; Plaskan, Jure; Weeks, Allen; Wosnitza, Joachim;In conjunction with the COVID-19 pandemic aftermath, Russian aggression on Ukraine has wide-ranging consequences for the EU, including high inflation, an immense energy cost increase, and a shortage of critical resources. All of these have pronounced effects on the sustainability and operations of research infrastructures (RIs), several of which face difficulties in providing continuous service. To address these topics, the European Strategy Forum on Research Infrastructures (ESFRI) has established a dedicated drafting group to look into the energy and supply challenges, also responding to a call by Competitiveness Council to do so. This report highlights the significant impact of the Russian aggression on Ukraine on the sustainability and operations of research infrastructures (RIs) in the EU. The energy crisis resulting from the Russian aggression poses a severe challenge to the RIs, predominantly analytical RIs, with energy-intensive RIs such as synchrotrons, computing centres, accelerator-driven particle sources, neutron facilities, research reactors, and lasers being the most affected. The shortage of critical resources and materials, such as some gases, rare isotopes, and permanent magnets, also presents a significant challenge to RIs, although they may not be a consequence of the war. The report presents recommendations to ESFRI, Member States, and the European Commission based on good practices from ESFRI member countries and the discussion within the drafting group to address these challenges and enhance the future resilience of RIs. The recommendations include allocating additional funds and energy price capping for the most energy-intensive RIs, developing response plans that include actions aimed at greening the operations of RIs, considering the needs of the RI communities in the activities linked to the Critical Raw Materials Regulation, and setting up specific measures to support the Ukrainian research community. The report emphasizes the importance of preparing for future crises, increasing the resilience and preparedness of European society to cope with any present and future crisis.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.8123921&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
visibility 351visibility views 351 download downloads 276 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.8123921&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2020 CroatiaPublisher:MDPI AG Funded by:HRZZ | Design and Synthesis of N...HRZZ| Design and Synthesis of Novel Nitrogen-Containing Heterocyclic Fluorophores and Fluorescent Nanomaterials for pH and Metal-Ion SensingTana Tandarić; Alja Prah; Jernej Stare; Janez Mavri; Robert Vianello;Monoamine oxidases (MAOs) catalyze the degradation of a very broad range of biogenic and dietary amines including many neurotransmitters in the brain, whose imbalance is extensively linked with the biochemical pathology of various neurological disorders, and are, accordingly, used as primary pharmacological targets to treat these debilitating cognitive diseases. Still, despite this practical significance, the precise molecular mechanism underlying the irreversible MAO inhibition with clinically used propargylamine inhibitors rasagiline and selegiline is still not unambiguously determined, which hinders the rational design of improved inhibitors devoid of side effects current drugs are experiencing. To address this challenge, we present empirical valence bond QM/MM simulations of the rate-limiting step of the MAO inhibition involving the hydride anion transfer from the inhibitor α-carbon onto the N5 atom of the flavin adenin dinucleotide (FAD) cofactor. The proposed mechanism is strongly supported by the obtained free energy profiles, which confirm a higher reactivity of selegiline over rasagiline, while the calculated difference in the activation Gibbs energies of ΔΔG‡ = 3.1 kcal mol−1 is found to be in very good agreement with that from the measured literature kinact values that predict a 1.7 kcal mol−1 higher selegiline reactivity. Given the similarity with the hydride transfer mechanism during the MAO catalytic activity, these results verify that both rasagiline and selegiline are mechanism-based irreversible inhibitors and offer guidelines in designing new and improved inhibitors, which are all clinically employed in treating a variety of neuropsychiatric and neurodegenerative conditions.
Full-text Institutio... arrow_drop_down International Journal of Molecular SciencesArticle . 2020 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijms21176151&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 17 citations 17 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
visibility 89visibility views 89 download downloads 79 Powered bymore_vert Full-text Institutio... arrow_drop_down International Journal of Molecular SciencesArticle . 2020 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijms21176151&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022Publisher:MDPI AG Authors: Borjana Kremžar Jovanović; Maja Smrdu; Rok Holnthaner; Tanja Kajtna;doi: 10.3390/su14052705
There is conflicting evidence that sport plays a protective role in the development of psychopathological disorders and contributes to the sustainability of mental health. The aim of the present study was to determine the prevalence of mental disorders among elite Slovenian athletes. We were interested in the prevalence of depression, anxiety, suicide risk, substance abuse, and eating disorders among athletes of both sexes and among athletes of individual and team sports aged 18 years or older. A total of 97 elite athletes participated in the study. We used PAI and EDI-3 questionnaires, and the study also included a control group of 90 non-athletes, matched in gender and age to the target group of elite athletes. Testing was conducted in 2020 and 2021. The comparison between elite athletes and the normative group showed a similar expression of depressive and anxious symptomatology. The athletes have a more pronounced drive for thinness and are more expansive, self-confident, and confident of their abilities compared to the control group. A total of 14% of the athletes show self-confidence to the point of self-grandiosity. Male athletes are more likely to use alcohol and other psychoactive substances and are also more impulsive and risk-taking, while female athletes are at higher risk of developing eating disorders. The study suggests that the prevalence of mental disorders in elite athletes is as high as in the general population. There is an urgent need to sustainably ensure the psychological well-being of athletes.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/su14052705&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/su14052705&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2021 SloveniaPublisher:MDPI AG Authors: Stanislav Avsec; Vesna Ferk Savec;doi: 10.3390/su131810443
Teacher education for sustainable development (ESD) is faced with continuing unsustainability trends, which require deep and enduring social transformation. Transformative learning is a possible solution to facilitating reflection on the cognitive and socio-emotional processes underpinning students’ learning towards sustainability. The purpose of this paper is to investigate students’ perceptions of, and experiences with, technology-enhanced self-directed learning and design thinking as possible moderators of transformative learning in order to advance the concept and practice of teacher ESD. These perceptions and experiences are represented by 225 pedagogical and non-pedagogical students from the University of Ljubljana, asked to respond anonymously to three online questionnaires in May and June 2021. Findings indicate that strengthening the transformative aspect of ESD in pre-service teachers requires the consideration of critical reflection, self-awareness, risk propensity, holistic view and openness to diversity, and social support. Moreover, self-directed learning was found to be a moderator for transformative learning among pre-service science teachers, while design thinking was evenly developed among transformative learning for both low- and high-ability students, no matter the study programme. The conditioning factors and explanatory arguments for these results are also discussed.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 13 citations 13 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Research , Preprint , Journal 2021Embargo end date: 01 Jan 2021 Argentina, Germany, France, Argentina, Czech Republic, Czech RepublicPublisher:Springer Science and Business Media LLC Funded by:ANR | SUPER, NSF | Pierre Auger ProjectANR| SUPER ,NSF| Pierre Auger ProjectG. Medina-Tanco; J. Stasielak; G. Farrar; Trent D. Grubb; Sullivan Marafico; F. C. T. Barbato; Rodrigo Guedes Lang; P. Abreu; Kai Daumiller; Adriana Vásquez-Ramírez; E.E. Pereira Martins; E.E. Pereira Martins; S. Querchfeld; Andres Travaini; Juan Manuel González; V. Scherini; François Montanet; Jonathan Blazek; Eleonora Guido; Marcel Köpke; J. de Oliveira; D. Lo Presti; A. M. Botti; Juan Miguel Carceller; O. Martínez Bravo; Jacco Vink; L. Perrone; M. Risse; A. Parra; A. Saftoiu; A. Machado Payeras; H. Wilczyński; Gualberto Avila; J. R. T. de Mello Neto; A.L. Garcia Vegas; I. Allekotte; B. Tome; Marc Weber; Kathrin Bismark; Kathrin Bismark; A. Di Matteo; Lorenzo Cazon; C. Pérez Bertolli; C. Pérez Bertolli; Alina Nasr-Esfahani; Paolo Privitera; Miguel Mostafa; M. E. Bertaina; W. M. Namasaka; Fabio Convenga; C. J.W.P. Timmermans; Fabian Gobbi; Fernando Contreras; L. Valore; A. Streich; A. Streich; Giovanni Consolati; Karen S. Caballero-Mora; Q. Luce; Raul Sarmento; M. Schimassek; M. Schimassek; Esteban Roulet; A. Haungs; J. Pȩkala; Martin Vacula; Virginia Binet; Vladimir Lenok; Niklas Langner; Carlos Escobar; Antonella Castellina; M. R. Hampel; Nataliia Borodai; A. A. Nucita; N. Kunka; Marco Aglietta; M. Zavrtanik; A.C. Cobos Cerutti; J. Rautenberg; R. López; Clara Keiko Oliveira Watanabe; R. Squartini; Josina Schulte; J. Vicha; M. del Río; Florian Lukas Briechle; Maximilian Stadelmaier; Maximilian Stadelmaier; G. De Mauro; J. Kleinfeller; M. Platino; John Matthews; M. Wirtz; S. Petrera; Giovanni Mancarella; Jon Paul Lundquist; Humberto Ibarguen Salazar; Octavian Sima; L. Nožka; Rossella Caruso; G. C. Hill; Carla Taricco; Kevin-Druis Merenda; Juan Pablo Gongora; Antonio Condorelli; Pierre Billoir; Philipp Papenbreer; Lino Miramonti; G. Golup; Carlo Ventura; G. Parente; Denis Stanca; Felix Schlüter; Felix Schlüter; Peter Buchholz; B. Andrada; R. Alves Batista; Toshihiro Fujii; Toshihiro Fujii; H. Martinez; A. Insolia; G. Cataldi; Alan Coleman; Corinne Berat; Cristina Galea; Alina Mihaela Badescu; G. P. Guedes; L. Lu; Orazio Zapparrata; B. Wundheiler; A. Filipčič; Peter L. Biermann; A. Weindl; Maria-Teresa Dova; Marcus Niechciol; E. De Vito; Jan Ebr; Jonathan Biteau; Isabel Goos; Isabel Goos; Jonas Glombitza; Fridtjof Feldbusch; D. D. dos Santos; Jeffrey Brack; V. de Souza; Radomir Smida; H.O. Klages; Jörg R. Hörandel; Ladislav Chytka; A. C. Fauth; M. I. Micheletti; Ioana Caracas; Julien Manshanden; L. Zehrer; W. Rodrigues de Carvalho; Vincenzo Rizi; Martina Bohacova; Zoé Torrès; Thomas Hebbeker; Frank G. Schröder; Frank G. Schröder; Petr Hamal; Alena Bakalova; Günter Sigl; Lukáš Vaclavek; J. Ridky; F. Riehn; Tomáš Fodran; K. Mulrey; Miroslav Pech; Juan Carlos D'Olivo; D. Ravignani; E. Varela; Markus Roth; M. A. Leigui de Oliveira; Claudio Galelli; Antonio Bueno; Marco Giammarchi; M. Palatka; R. Sato; Roberto Mussa; Olivier Deligny; C. Hojvat; Fabrizia Canfora; Sara Martinelli; Sara Martinelli; L. M. Domingues Mendes; David Wittkowski; P.R. Araújo Ferreira; Max Büsken; Max Büsken; Thomas Bretz; S. J. De Jong; M. Unger; Carla Aramo; M. Kleifges; Daniela Mockler; Daniela Mockler; Marcos Cerda; Serguei Vorobiov;doi: 10.1140/epjc/s10052-021-09700-w , 10.48550/arxiv.2109.13400 , 10.18154/rwth-2021-12100 , 10.18154/rwth-2022-00047
arXiv: 2109.13400
handle: 2133/23683
doi: 10.1140/epjc/s10052-021-09700-w , 10.48550/arxiv.2109.13400 , 10.18154/rwth-2021-12100 , 10.18154/rwth-2022-00047
arXiv: 2109.13400
handle: 2133/23683
AbstractWe present a measurement of the cosmic-ray spectrum above 100 PeV using the part of the surface detector of the Pierre Auger Observatory that has a spacing of 750 m. An inflection of the spectrum is observed, confirming the presence of the so-called second-knee feature. The spectrum is then combined with that of the 1500 m array to produce a single measurement of the flux, linking this spectral feature with the three additional breaks at the highest energies. The combined spectrum, with an energy scale set calorimetrically via fluorescence telescopes and using a single detector type, results in the most statistically and systematically precise measurement of spectral breaks yet obtained. These measurements are critical for furthering our understanding of the highest energy cosmic rays.
RepHipUNR - Reposito... arrow_drop_down RepHipUNR - Repositorio Hipermedial de la Universidad Nacional de RosarioArticle . 2021License: CC BYData sources: Bielefeld Academic Search Engine (BASE)KITopen (Karlsruhe Institute of Technologie)Article . 2021License: CC BYData sources: Bielefeld Academic Search Engine (BASE)European Physical Journal C: Particles and FieldsArticle . 2021 . Peer-reviewedLicense: CC BYData sources: CrossrefRecolector de Ciencia Abierta, RECOLECTAArticle . 2021License: CC BYData sources: Recolector de Ciencia Abierta, RECOLECTARepository of the Czech Academy of SciencesArticle . 2021Data sources: Repository of the Czech Academy of SciencesMémoires en Sciences de l'Information et de la CommunicationPreprint . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1140/epjc/s10052-021-09700-w&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 58 citations 58 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert RepHipUNR - Reposito... arrow_drop_down RepHipUNR - Repositorio Hipermedial de la Universidad Nacional de RosarioArticle . 2021License: CC BYData sources: Bielefeld Academic Search Engine (BASE)KITopen (Karlsruhe Institute of Technologie)Article . 2021License: CC BYData sources: Bielefeld Academic Search Engine (BASE)European Physical Journal C: Particles and FieldsArticle . 2021 . Peer-reviewedLicense: CC BYData sources: CrossrefRecolector de Ciencia Abierta, RECOLECTAArticle . 2021License: CC BYData sources: Recolector de Ciencia Abierta, RECOLECTARepository of the Czech Academy of SciencesArticle . 2021Data sources: Repository of the Czech Academy of SciencesMémoires en Sciences de l'Information et de la CommunicationPreprint . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1140/epjc/s10052-021-09700-w&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Frontiers Media SA Authors: ZhaoHong Han; Gang Bao;One of the most fascinating, consequential, and far-reaching debates that have occurred in second language acquisition research concerns the Critical Period Hypothesis [1]. Although the hypothesis is generally accepted for first language acquisition, it has been hotly debated on theoretical, methodological, and practical grounds for second language acquisition, fueling studies reporting contradictory findings and setting off competing explanations. The central questions are: Are the observed age effects in ultimate attainment confined to a bounded period, and if they are, are they biologically determined or maturationally constrained? In this article, we take asui generis, interdisciplinary approach that leverages our understanding of second language acquisition and of physics laws of energy conservation and angular momentum conservation, mathematically deriving the age-attainment geometry. The theoretical lens, termed Energy Conservation Theory for Second Language Acquisition, provides a macroscopic perspective on the second language learning trajectory across the human lifespan.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fphy.2023.1142584&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fphy.2023.1142584&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016Publisher:Engineering Society of Corrosion Funded by:MESTD | Biodiversity as potential..., EC | AREAMESTD| Biodiversity as potential in ecoremediation technologies of degraded ecosystems ,EC| AREAIlić, Dora; Radić, Danka; Karličić, Vera; Jovičić-Petrović, Jelena; Kiković, Dragan; Lalević, Blažo; Raičević, Vera;Except of benefits for human population, several industrial activities have a negative consequences i.e. increasing of heavy metal content and changes in diversity of living organisms in environment. The aim of this work was to examinated the influence of high content of heavy metals on microbial diversity of soil. Researches was conducted at locations of former factory 'Rog' (Ljubljana, Republic of Slovenia), by taking of four samples of contaminated soil, while the control was uncontaminated soil sample. Determination of microbial diversity (abundance of bacteria, fungi and actinomycetes) was performed using the standard methodology. The results of research showed that abundance of microorganisms depends on location and presence/absence of contamination. In control treatment abundance of all examinated groups of microorganisms was higher compared with other samples. The bacterial number in contaminated samples was from 1.21 to 6.88x106 CFU/g, the number of fungi was from 1,08 to 30,30x103 CFU/g, while actinomycetes number from 302,15 to 381,82x103 CFU/g. In control treatment, bacterial number was 17,45x106 CFU/g, fungi number 54,02x103 CFU/g and actinomycetes number 481,91x103 CFU/g. These results confirms the importance of microbial diversity research on contaminated locations and potential applications of bioremediation technologies on locations of former factory 'Rog'.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5937/zasmat1603383i&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
visibility 32visibility views 32 download downloads 82 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5937/zasmat1603383i&type=result"></script>'); --> </script>
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