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The numerous adverse effects of ethanol abuse and ethanol withdrawal on biological systems are well documented. Conversely, the understanding of the molecular mechanisms underlying these pathological effects is still incomplete. This study was undertaken to investigate the effects of short-term chronic ethanol administration and ethanol withdrawal on the molecular structure and function of hippocampal tissue, a brain region important for mnemonic processes and known to be highly susceptible to ethanol intoxication.Ethanol was administered to adult Wistar rats by intragastric intubation for 15 days with a stepwise increase in the daily dose from 6 to 12 g/kg body weight, with the highest dose delivered for the last 2 days only. The total daily dose of ethanol was divided into 3 equal portions administered 4 hours apart. Animals were sacrificed by decapitation at 4, 24, and 72 hours after the last ethanol administration to examine potential effects of ethanol intoxication and ethanol withdrawal. Ethanol-related molecular changes were monitored by Fourier transform infrared (FT-IR) spectroscopy.Significant changes in the hippocampal content, structure, and function of lipids, proteins, and nucleic acids were recorded under ethanol intoxication. Seventy-two hours after the cessation of ethanol administration, during the late phase of withdrawal, alterations in the macromolecules' content and conformational changes in protein and nucleic acid structure ameliorated, while the changes in macromolecular ratios, lipid order, and dynamics aggravated.Our results suggest that 15 days of binge-like drinking resulting in the high blood alcohol concentration (varying in the dose-dependent manner between 253 and 606 mg/dl) produced a strong physical dependence manifested mainly by the changes in lipid profiles pointing toward withdrawal-induced oxidative stress. These results show that ethanol withdrawal may cause equal to or even more severe brain damage than the ethanol itself, which should be considered when designing antialcohol therapies.

AbstractFor wind turbine blades with the increased slenderness ratio, flutter instability may occur at lower wind and rotational speeds. For long blades, at the flutter condition, relative velocities at blade sections away from the hub center are usually in the subsonic compressible range. In this study, for the first time for composite wind turbine blades, a frequency domain classical flutter analysis methodology has been presented including the compressibility effect only for the outboard blade sections, which are in the compressible flow regime exceeding Mach 0.3. Flutter analyses have been performed for the baseline blade designed for the 5‐MW wind turbine of NREL. Beam‐blade model has been generated by making analogy with the structural model of the prewisted rotating thin‐walled beam (TWB) and variational asymptotic beam section (VABS) method has been utilized for the calculation of the sectional properties of the blade. To investigate the compressibility effect on the flutter characteristics of the blade, frequency and time domain aeroelastic analyses have been conducted by utilizing unsteady aerodynamics via incompressible and compressible indicial functions. This study shows that with use of compressible indicial functions, the effect of compressibility can be taken into account effectively in the frequency domain aeroelastic stability analysis of long blades whose outboard sections are inevitably in the compressible flow regime at the onset of flutter.

Bioenergy is considered a sustainable substitute to fossil-fuel resources and the development of a prudent combination of renewable and innovative conversion technologies are essential for the valorization and effective conversion of biowaste to value-added commodities. Here, a negative pressure-induced carbonization process was proposed for the valorization of lignin-enriched biowaste precursor to bio-oil and environmental materials (biochar) at various temperatures. The high heating values (HHV) of the as-prepared biochars from the lignin enriched precursor under negative pressure (low-medium vacuum) were within 25.9-31.5 MJ/kg, which matched satisfactorily to the commercial charcoal. Whereas, the bio-oils produced from the lignin enriched precursor under vacuum conditions was a blend of complex aromatic and straight-chain hydro-carbons, including aldehyde, ketone, phenol, and furans, exhibiting ability as potential heating-oil with HHV within 21.2-28.2 MJ/kg. Moreover, the biochars produced under vacuum environments at higher temperature showed greater stability (22.5-35.9%) than those produced under N2 atmosphere.

This study investigates a passive cooling system for horizontal concentrating (Hor-Con) photovoltaic (PV) modules. Maintaining operating temperatures within an optimal range is crucial for efficiency, as in concentrating photovoltaics (CPV). Unlike traditional CPV systems where cooling elements such as fins are positioned at the back of the solar panel, this design extends plate fins toward the front, preventing hot air accumulation and enhancing cooling. Its simplicity and compatibility with the Hor-Con PV's linear concentration ensure seamless integration. The primary goal is to keep cell temperatures below 70 ∘C under high irradiation. Key findings show that increasing the fin height enhances heat dissipation, while wind speed strongly influences cooling. With a wind speed of 1 ms−1, operational temperatures are reduced by 10–15 ∘C, and an increase to 3.6 ms−1 yields an additional 5–10 ∘C reduction. The mean thermal efficiency for the extended fins is 58.9% (10 cm), 63.3% (12 cm), and 66.1% (14 cm), with all configurations maintaining temperatures below the threshold. The findings confirm that Hor-Con PV systems with proposed plate fins could maintain reliable operation under high-irradiation conditions, while also demonstrating measurable efficiency gains.

In Rhizopus oryzae cultivations, lactate production decreased and ethanol and biomass productions increased as inoculated spore concentration increased. Spore concentrations of 1 x 10(3) and 1 x 10(4) spores ml(-1) induced tightly packed clumps, whereas 1 x 10(5) and 1 x 10(6) spores ml(-1) induced filamentous growth.

Benchmarking the performance of cities across aspects that relate to the sustainable development of energy, water and environment systems requires an integrated approach. This paper benchmarks a sample of 12 Southeast European cities based on a composite indicator that consists of 7 dimensions and 35 main indicators. The composite indicator is namely the Sustainable Development of Energy, Water and Environment Systems (SDEWES) City Sustainability Index. The first three dimensions are energy consumption and climate, penetration of energy and carbon dioxide saving measures, and renewable energy potential and utilization. The last four dimensions are water and environmental quality, carbon dioxide emissions and industrial profile, city planning and social welfare, and research, development, innovation, and sustainability policy. The data collection process for the 12 cities integrates data from Sustainable Energy Action Plans and other sources. Data entries are normalized based on the Min–Max method and aggregated for a final ranking. Zagreb, Bucharest (District 1), and Ohrid are the top three cities. An average city receives a composite score of 2.69. Best practices are identified to allow cities to adopt well-rounded efforts to improve future performance. The SDEWES Index is useful to trigger learning, action, and collaboration among cities to transition to a more sustainable future.

A search is presented for new physics in events with two low-momentum, oppositely charged leptons (electrons or muons) and missing transverse momentum in proton-proton collisions at a centre-of-mass energy of 13 TeV. The data collected using the CMS detector at the LHC correspond to an integrated luminosity of 35.9. The observed event yields are consistent with the expectations from the standard model. The results are interpreted in terms of pair production of charginos and neutralinos (X1 and X2) with nearly degenerate masses, as expected in natural supersymmetry models with light higgsinos, as well as in terms of the pair production of top squarks (t), when the lightest neutralino and the top squark have similar masses. At 95% confidence level, wino-like X1/X2 masses are excluded up to 230 GeV for a mass difference of 20 GeV relative to the lightest neutralino. In the higgsino-like model, masses are excluded up to 168 GeV for the same mass difference. For pair production, top squark masses up to 450 GeV are excluded for a mass difference of 40 GeV relative to the lightest neutralino. Physics Letters B, 782 ISSN:0370-2693 ISSN:0031-9163 ISSN:1873-2445