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Research and clinical applications have demonstrated that the effects of tendon allografts are comparable to those of autografts when reconstructing injured tendons or ligaments, but allograft safety remains problematic. Sterilisation could eliminate or decrease the possibility of disease transmission, but current methods seldom achieve satisfactory sterilisation without affecting the mechanical properties of the tendon.Peracetic acid-ethanol in combination with low-dose gamma irradiation (PE-R) would inactivate potential deleterious microorganisms without affecting mechanical and biocompatible properties of tendon allograft.Controlled laboratory design.HIV, PPV, PRV and BVDV inactivation was evaluated. After verifying viral inactivation, the treated tendon allografts were characterised by optical microscopy, scanning electron microscopy and tensile testing, and the cytocompatibility was assessed with an MTT assay and by subcutaneous implantation.Effective and efficient inactivation of HIV, PPV, PRV and BVDV was observed. Histological structure and ultrastructure were unchanged in the treated tendon allograft, which also exhibited comparable biomechanical properties and good biocompatibility.The preliminary results confirmed our hypothesis and demonstrated that the PE-R tendon allograft has significant potential as an alternative to ligament/tendon reconstruction.Tendon allografts have been extensively used in ligament reconstruction and tendon repair. However, current sterilisation methods have various shortcomings, so PE-R has been proposed. This study suggests that PE-R tendon allograft has great potential as an alternative for ligament/tendon reconstruction.Sterilisation has been a great concern for tendon allografts. However, most sterilisation methods cannot inactivate viruses and bacteria without impairing the mechanical properties of the tendon allograft.Peracetic acid/ethanol with gamma irradiation can effectively inactivate viruses and bacteria. Meanwhile, tendon allografts sterilised by this method maintain their physiological tendon structure, biomechanical integrity and good compatibility.

Current energy market designs and pricing schemes fail to give investors the appropriate market signals. In particular, energy prices are not high enough to attract investors to build new or maintain existing power capacity. In this paper we propose a method to compute second-best Pareto optimal equilibrium prices for any market exhibiting non-convexities and, based on this result, an energy market design able to restore the correct energy price signals for supply investors.

To report the clinical efficiency and complications in patients treated with retrograde transvenous ethanol embolization of high-flow peripheral arteriovenous malformations (AVMs). Retrograde transvenous ethanol embolization of high-flow AVMs is a technique that can be used to treat AVMs with a dominant outflow vein whenever conventional interventional procedures have proved insufficient.This is a retrospective study of the clinical effectiveness and complications of retrograde embolization in five patients who had previously undergone multiple arterial embolization procedures without clinical success.Clinical outcomes were good in all patients but were achieved at the cost of serious, although transient, complications in three patients.Retrograde transvenous ethanol embolization is a highly effective therapy for high-flow AVMs. However, because of the high complication rate, it should be reserved as a last resort, to be used after conventional treatment options have failed.

Direct Load Control (DLC) is an effective instrument for achieving a guaranteed load curtailment. Unfortunately, if a customer considers that personal discomfort outweighs money savings after DLC shutting down of home appliances, DLC solution can be rejected. This paper proposes the way to remediate customer comfort concerns by pre-storing additional energy in electric loads before their disconnection from the grid. We take electric tank water heaters as an illustrative example of residential loads with storage. To illuminate our approach we first show how to balance electric consumption for pre-storing with user thermal discomfort for a single water heater. Then, we illustrate how the approach can be scaled-up to a multiple-boiler scenario, when ten remotely controlled boilers act next to fifty non-controlled boilers. The simulations for the latter case show that the expected user thermal discomfort can be significantly reduced at the cost of a reasonable increase of electricity demand preceding DLC event.

Abstract In many visions and roadmaps, there is a broad agreement that fuel cells – both for stationary and mobile applications – are the key technology to allow the development of a hydrogen infrastructure. Furthermore, this development is generally thought to be based on a gradual, decentralised evolution. Nevertheless, in this paper it is argued that, taking into account the entire hydrogen chain (production, transport, storage, distribution and end-use), this decentralised fuel-cell based philosophy shows some serious flaws. Therefore, a new hydrogen-transition approach was pushed forward: mixing in of hydrogen into the natural-gas bulk. Using Flanders – the Northern part of Belgium – as a case study, the development of a transitory hydrogen infrastructure has been studied, taking into account the entire hydrogen chain and its dynamics, from production to end use. In a next step, this transition is being quantified. An optimisation model has been developed using Matlab and the commercial solvers GAMS and CPLEX. Following a mixed-integer linear-programming approach, this model is able to determine the economically optimal hydrogen-production mix and operational behaviour of each hydrogen-production plant separately. The model then allows gaining valuable insights in the importance of storage and the influence of fuel prices and carbon taxes with regard to the development of an early hydrogen economy.

The unpredictable nature of wind energy makes its integration to the electric grid highly challenging. However, these challenges can be addressed by incorporating storage devices (batteries) in the system. We perform an overall assessment of a single domestic power system with a wind turbine supported by an energy storage device. The aim is to investigate the best operation mode of the storage device such that the occurrence of large power spills can be minimized. For estimating the small probability of large power spills, we use the splitting technique for rare-event simulations. An appropriate Importance Function for splitting is formulated such that it reduces the work-load of the probability estimator as compared to the conventional Crude Monte Carlo probability estimator. Simulation results show that the ramp constraints imposed on the charging/discharging rate of the storage device plays a pivotal role in mitigating large power spills. It is observed that by employing a new charging strategy for the storage device large power spills can be minimized further. There exists a trade-off between reducing the large power spills versus reducing the average power spills.

The experimental study is conducted to investigate the public opinion on how immigration leads to overpopulation and in turn might damage the sustainable development and environmental protection.