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description Publicationkeyboard_double_arrow_right Article , Journal 2012 FrancePublisher:Wiley Larbat, Romain; Le Bot, Jacques; Bourgaud, Frederic; Robin, Christophe; Adamowicz, Stephane;pmid: 22372822
AbstractPhenolic compounds are secondary metabolites involved in plant innate chemical defence against pests and diseases. Their concentration varies depending on plant tissue and also on genetic and environmental factors, e.g. availability of nutrient resources. This study examines specific effects of low (LN) and high (HN) nitrogen supply on organ (root, stem and leaf) growth and accumulation of major phenolics [chlorogenic acid (CGA); rutin; kaempferol rutinoside (KR)] in nine hydroponically grown tomato cultivars. LN limited shoot growth but did not affect root growth, and increased concentrations of each individual phenolic in all organs. The strength of the response was organ‐dependent, roots being more responsive than leaves and stems. Significant differences were observed between genotypes. Nitrogen limitation did not change the phenolic content in shoots, whereas it stimulated accumulation in roots. The results show that this trade‐off between growth and defence in a LN environment can be discussed within the framework of the growth–differentiation balance hypothesis (i.e. GDBH), but highlight the need to integrate all plant organs in future modelling approaches regarding the impact of nitrogen limitation on primary and secondary metabolism.
HAL INRAE arrow_drop_down Institut National de la Recherche Agronomique: ProdINRAArticle . 2012Data sources: Bielefeld Academic Search Engine (BASE)Plant BiologyArticle . 2012 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1438-8677.2012.00564.x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert HAL INRAE arrow_drop_down Institut National de la Recherche Agronomique: ProdINRAArticle . 2012Data sources: Bielefeld Academic Search Engine (BASE)Plant BiologyArticle . 2012 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1438-8677.2012.00564.x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 1997Publisher:American Physiological Society Authors: John L. Wallace; JoséGeraldo P. Ferraz; A. W. Tigley; Caroline B. Appleyard;pmid: 9142912
Cirrhotic rats exhibit increased susceptibility to ethanol-induced gastric damage, but the underlying mechanism for this phenomenon remains unclear. Abnormalities of the gastric microcirculation have been reported that may contribute to the increased susceptibility to damage. Decreased gastric synthesis of prostaglandins also likely contributes to impaired mucosal defense in cirrhotic rats. Tumor necrosis factor-alpha (TNF-alpha) has been implicated in mucosal injury, and its synthesis can be inhibited by prostaglandins. Therefore, we hypothesized that TNF-alpha synthesis/ release is altered in cirrhotic rats and plays a role in the pathogenesis of ethanol-induced gastric damage. Cirrhosis was induced by bile duct ligation, whereas controls had sham operations. Topical application of 40% ethanol caused four times as much damage in cirrhotic rats than in controls. Basal plasma TNF-alpha levels did not differ between control and cirrhotic rats, although cirrhotic rats exhibited significantly higher levels of gastric TNF-alpha mRNA. Plasma TNF-alpha increased significantly in control and cirrhotic rats after ethanol administration. Inhibition of TNF-alpha synthesis/release with pentoxifylline, thalidomide, dexamethasone, or immunoneutralization of TNF-alpha (with anti-TNF-alpha) was found to significantly reduce the severity of ethanol-induced gastric mucosal damage in cirrhotic rats. We conclude that TNF-alpha contributes to the pathogenesis of ethanol-induced gastric damage in cirrhotic rats.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1152/ajpgi.1997.272.4.g809&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1152/ajpgi.1997.272.4.g809&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 1971add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=4098185&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=4098185&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022Publisher:Elsevier BV Tian Tian; Shengju Yin; Yongyan Chen; Chengrong Wang; Mengyuan Liu; Lei Jin; Zhiwen Li; Jufen Liu; Yali Zhang; Linlin Wang; Aiguo Ren;pmid: 35780851
Chromium (Cr) exposure during gestation causes malformations in animal experiments. In this multicenter case-control study, we initially involved 130 orofacial clefts (OFCs) and 260 controls to assess the association between Cr concentration and risk for OFCs. Then, umbilical cord serum (49 vs. 119) and cord tissue (84 vs. 142) were used to validate the association between Cr and OFCs. We found that maternal serum Cr concentrations in OFC cases were significantly higher than those in controls. Compared with the lowest tertile of maternal serum Cr concentration, the highest tertile of Cr increased the risk for OFCs [OR = 2.14 (1.14-4.05)]. In the validation cohort of umbilical cord serum and tissue, higher concentrations of Cr were associated with increased risks for OFCs in a dose-dependent manner (all Ps for trends <0.05). Cr concentrations in maternal serum and cord serum showed a positive correlation. The Cr concentration in cord serum was inversely correlated with egg and milk consumption frequencies, and the Cr concentration in cord tissue was positively associated with indoor coal burning. In conclusion, prenatal Cr exposure is a risk factor for OFCs, and indoor coal burning during pregnancy may be one of the sources of Cr exposure.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.envres.2022.113799&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.envres.2022.113799&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2009 ItalyPublisher:Oxford University Press (OUP) Authors: Micheletti, Cristian; ORLAND H.;Abstract Motivation: The steady growth of the number of available protein structures has constantly motivated the development of new algorithms for detecting structural correspondences in proteins. Detecting structural equivalences in two or more proteins is computationally demanding as it typically entails the exploration of the combinatorial space of all possible amino acid pairings in the parent proteins. The search is often aided by the introduction of various constraints such as considering protein fragments, rather than single amino acids, and/or seeking only sequential correspondences in the given proteins. An additional challenge is represented by the difficulty of associating to a given alignment, a reliable a priori measure of its statistical significance. Results: Here, we present and discuss MISTRAL (Multiple STRuctural ALignment), a novel strategy for multiple protein alignment based on the minimization of an energy function over the low-dimensional space of the relative rotations and translations of the molecules. The energy minimization avoids combinatorial searches and returns pairwise alignment scores for which a reliable a priori statistical significance can be given. Availability: MISTRAL is freely available for academic users as a standalone program and as a web service at http://ipht.cea.fr/protein.php. Contact: michelet@sissa.it Supplementary information: Supplementary data are available at Bioinformatics online.
Bioinformatics arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/bioinformatics/btp506&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert Bioinformatics arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/bioinformatics/btp506&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 1986add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=2941211&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=2941211&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint , Journal 2018 ChilePublisher:PeerJ Dominique Alò; Dominique Alò; Andrea Castillo; Horacio Samaniego; Benito A. González;Background The main goal of this contribution was to define the ecological niche of the guanaco (Lama guanicoe), to describe potential distributional changes, and to assess the relative importance of niche conservatism and divergence processes between the two lineages described for the species (L.g. cacsilensis and L.g. guanicoe). Methods We used maximum entropy to model lineage’s climate niche from 3,321 locations throughout continental Chile, and developed future niche models under climate change for two extreme greenhouse gas emission scenarios (RCP2.6 and RCP8.5). We evaluated changes of the environmental niche and future distribution of the largest mammal in the Southern Cone of South America. Evaluation of niche conservatism and divergence were based on identity and background similarity tests. Results We show that: (a) the current geographic distribution of lineages is associated with different climatic requirements that are related to the geographic areas where these lineages are located; (b) future distribution models predict a decrease in the distribution surface under both scenarios; (c) a 3% decrease of areal protection is expected if the current distribution of protected areas is maintained, and this is expected to occur at the expense of a large reduction of high quality habitats under the best scenario; (d) current and future distribution ranges of guanaco mostly adhere to phylogenetic niche divergence hypotheses between lineages. Discussion Associating environmental variables with species ecological niche seems to be an important aspect of unveiling the particularities of, both evolutionary patterns and ecological features that species face in a changing environment. We report specific descriptions of how these patterns may play out under the most extreme climate change predictions and provide a grim outlook of the future potential distribution of guanaco in Chile. From an ecological perspective, while a slightly smaller distribution area is expected, this may come with an important reduction of available quality habitats. From the evolutionary perspective, we describe the limitations of this taxon as it experiences forces imposed by climate change dynamics.
PeerJ Preprints arrow_drop_down PeerJ PreprintsPreprint . 2018License: CC BYFull-Text: https://peerj.com/preprints/3517.pdfData sources: PeerJ PreprintsPeerJ PreprintsPreprint . 2018License: CC BYFull-Text: https://peerj.com/preprints/3517v1.pdfData sources: PeerJ PreprintsUniversidad de Chile: Repositorio académicoArticle . 2018License: CC BY NC NDData sources: Bielefeld Academic Search Engine (BASE)https://doi.org/10.7287/peerj....Article . 2018 . Peer-reviewedLicense: CC BYData sources: CrossrefPontificia Universidad Católica de Chile: Repositorio UCArticle . 2020Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7717/peerj.4907&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert PeerJ Preprints arrow_drop_down PeerJ PreprintsPreprint . 2018License: CC BYFull-Text: https://peerj.com/preprints/3517.pdfData sources: PeerJ PreprintsPeerJ PreprintsPreprint . 2018License: CC BYFull-Text: https://peerj.com/preprints/3517v1.pdfData sources: PeerJ PreprintsUniversidad de Chile: Repositorio académicoArticle . 2018License: CC BY NC NDData sources: Bielefeld Academic Search Engine (BASE)https://doi.org/10.7287/peerj....Article . 2018 . Peer-reviewedLicense: CC BYData sources: CrossrefPontificia Universidad Católica de Chile: Repositorio UCArticle . 2020Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7717/peerj.4907&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2020Publisher:MDPI AG Lei Feng; Jiejie Sun; Yuanbao Shi; Guibin Wang; Tongli Wang;Camptotheca acuminata is considered a natural medicinal plant with antitumor activity. The assessment of climate change impact on its suitable habitats is important for cultivation and conservation. In this study, we applied a novel approach to build ecological niche models with both climate and soil variables while the confounding effects between the variables in the two categories were avoided. We found that the degree-days below zero and mean annual precipitation were the most important climatic factors, while the basic soil saturation, soil gravel volume percentage, and clay content were the main soil factors, determining the suitable habitats of C. acuminata. We found that suitable habitats of this species would moderately increase in future climates under both the RCP4.5 and RCP8.5 climate change scenarios for the 2020s, 2050s, and 2080s. However, substantial shifts among levels of habitat suitability were projected. The dual high-suitable habitats would expand, which would be favorable for commercial plantations. Our findings contribute to a better understanding of the impact of climate change on this species and provide a scientific basis for the cultivation and conservation purposes.
Forests arrow_drop_down ForestsOther literature type . 2020License: CC BYFull-Text: http://www.mdpi.com/1999-4907/11/8/891/pdfData sources: Multidisciplinary Digital Publishing Instituteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/f11080891&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert Forests arrow_drop_down ForestsOther literature type . 2020License: CC BYFull-Text: http://www.mdpi.com/1999-4907/11/8/891/pdfData sources: Multidisciplinary Digital Publishing Instituteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/f11080891&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 1982Publisher:Informa UK Limited S.H. Harmon; Leroy B. Yeatts; T.K. Rao; G. M. Henderson; John E. Caton; Wayne H. Griest;pmid: 6757160
Post-electrostatic precipitator (ESP) fly ash samples were collected from a coal-fired electric power generation plant under three modes of plant operation: normal operation, a low NOx-emission mode of combustion, and operation with the ESP shorted-out. Results of chemical and physical characterization of the ashes were compared with bacterial mutagenicity bioassay to determine parameters or compounds correlating with bioactivity. The general physical properties, ultimate composition, and trace elemental and radiochemical species determined did not correlate with the mutagenicity. Only the presence of aromatic hydrocarbons and chemically derivatizable polar organic compounds appeared to be associated with mutagenicity of the fly ash.
International Journa... arrow_drop_down International Journal of Environmental & Analytical ChemistryArticle . 1982 . Peer-reviewedData sources: CrossrefInternational Journal of Environmental & Analytical ChemistryArticle . 1983Data sources: Europe PubMed CentralInternational Journal of Environmental & Analytical ChemistryJournalData sources: Microsoft Academic Graphadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/03067318208078331&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert International Journa... arrow_drop_down International Journal of Environmental & Analytical ChemistryArticle . 1982 . Peer-reviewedData sources: CrossrefInternational Journal of Environmental & Analytical ChemistryArticle . 1983Data sources: Europe PubMed CentralInternational Journal of Environmental & Analytical ChemistryJournalData sources: Microsoft Academic Graphadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/03067318208078331&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2016Publisher:Ivyspring International Publisher Funded by:NIH | DISEASE MODELING OF ALCOH...NIH| DISEASE MODELING OF ALCOHOL RELATED HEPATOCELLULAR CARCINOMA USING PATIENT IPSCSAuthors: Yoon Young Jang; Abhijeet Deshmukh; Lipeng Tian; Neha Prasad;Alcohol consumption has long been a global problem affecting human health, and has been found to influence both fetal and adult liver functions. However, how alcohol affects human liver development and liver progenitor cells remains largely unknown. Here, we used human induced pluripotent stem cells (iPSCs) as a model to examine the effects of alcohol, on multi-stage hepatic cells including hepatic progenitors, early and mature hepatocyte-like cells derived from human iPSCs. While alcohol has little effect on endoderm development from iPSCs, it reduces formation of hepatic progenitor cells during early hepatic specification. The proliferative activities of early and mature hepatocyte-like cells are significantly decreased after alcohol exposure. Importantly, at a mature stage of hepatocyte-like cells, alcohol treatment increases two liver progenitor subsets, causes oxidative mitochondrial injury and results in liver disease phenotypes (i.e., steatosis and hepatocellular carcinoma associated markers) in a dose dependent manner. Some of the phenotypes were significantly improved by antioxidant treatment. This report suggests that fetal alcohol exposure may impair generation of hepatic progenitors at early stage of hepatic specification and decrease proliferation of fetal hepatocytes; meanwhile alcohol injury in post-natal or mature stage human liver may contribute to disease phenotypes. This human iPSC model of alcohol-induced liver injury can be highly valuable for investigating alcoholic injury in the fetus as well as understanding the pathogenesis and ultimately developing effective treatment for alcoholic liver disease in adults.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7150/ijbs.15811&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7150/ijbs.15811&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article , Journal 2012 FrancePublisher:Wiley Larbat, Romain; Le Bot, Jacques; Bourgaud, Frederic; Robin, Christophe; Adamowicz, Stephane;pmid: 22372822
AbstractPhenolic compounds are secondary metabolites involved in plant innate chemical defence against pests and diseases. Their concentration varies depending on plant tissue and also on genetic and environmental factors, e.g. availability of nutrient resources. This study examines specific effects of low (LN) and high (HN) nitrogen supply on organ (root, stem and leaf) growth and accumulation of major phenolics [chlorogenic acid (CGA); rutin; kaempferol rutinoside (KR)] in nine hydroponically grown tomato cultivars. LN limited shoot growth but did not affect root growth, and increased concentrations of each individual phenolic in all organs. The strength of the response was organ‐dependent, roots being more responsive than leaves and stems. Significant differences were observed between genotypes. Nitrogen limitation did not change the phenolic content in shoots, whereas it stimulated accumulation in roots. The results show that this trade‐off between growth and defence in a LN environment can be discussed within the framework of the growth–differentiation balance hypothesis (i.e. GDBH), but highlight the need to integrate all plant organs in future modelling approaches regarding the impact of nitrogen limitation on primary and secondary metabolism.
HAL INRAE arrow_drop_down Institut National de la Recherche Agronomique: ProdINRAArticle . 2012Data sources: Bielefeld Academic Search Engine (BASE)Plant BiologyArticle . 2012 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1438-8677.2012.00564.x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert HAL INRAE arrow_drop_down Institut National de la Recherche Agronomique: ProdINRAArticle . 2012Data sources: Bielefeld Academic Search Engine (BASE)Plant BiologyArticle . 2012 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 1997Publisher:American Physiological Society Authors: John L. Wallace; JoséGeraldo P. Ferraz; A. W. Tigley; Caroline B. Appleyard;pmid: 9142912
Cirrhotic rats exhibit increased susceptibility to ethanol-induced gastric damage, but the underlying mechanism for this phenomenon remains unclear. Abnormalities of the gastric microcirculation have been reported that may contribute to the increased susceptibility to damage. Decreased gastric synthesis of prostaglandins also likely contributes to impaired mucosal defense in cirrhotic rats. Tumor necrosis factor-alpha (TNF-alpha) has been implicated in mucosal injury, and its synthesis can be inhibited by prostaglandins. Therefore, we hypothesized that TNF-alpha synthesis/ release is altered in cirrhotic rats and plays a role in the pathogenesis of ethanol-induced gastric damage. Cirrhosis was induced by bile duct ligation, whereas controls had sham operations. Topical application of 40% ethanol caused four times as much damage in cirrhotic rats than in controls. Basal plasma TNF-alpha levels did not differ between control and cirrhotic rats, although cirrhotic rats exhibited significantly higher levels of gastric TNF-alpha mRNA. Plasma TNF-alpha increased significantly in control and cirrhotic rats after ethanol administration. Inhibition of TNF-alpha synthesis/release with pentoxifylline, thalidomide, dexamethasone, or immunoneutralization of TNF-alpha (with anti-TNF-alpha) was found to significantly reduce the severity of ethanol-induced gastric mucosal damage in cirrhotic rats. We conclude that TNF-alpha contributes to the pathogenesis of ethanol-induced gastric damage in cirrhotic rats.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1152/ajpgi.1997.272.4.g809&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1152/ajpgi.1997.272.4.g809&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 1971add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=4098185&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=4098185&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022Publisher:Elsevier BV Tian Tian; Shengju Yin; Yongyan Chen; Chengrong Wang; Mengyuan Liu; Lei Jin; Zhiwen Li; Jufen Liu; Yali Zhang; Linlin Wang; Aiguo Ren;pmid: 35780851
Chromium (Cr) exposure during gestation causes malformations in animal experiments. In this multicenter case-control study, we initially involved 130 orofacial clefts (OFCs) and 260 controls to assess the association between Cr concentration and risk for OFCs. Then, umbilical cord serum (49 vs. 119) and cord tissue (84 vs. 142) were used to validate the association between Cr and OFCs. We found that maternal serum Cr concentrations in OFC cases were significantly higher than those in controls. Compared with the lowest tertile of maternal serum Cr concentration, the highest tertile of Cr increased the risk for OFCs [OR = 2.14 (1.14-4.05)]. In the validation cohort of umbilical cord serum and tissue, higher concentrations of Cr were associated with increased risks for OFCs in a dose-dependent manner (all Ps for trends <0.05). Cr concentrations in maternal serum and cord serum showed a positive correlation. The Cr concentration in cord serum was inversely correlated with egg and milk consumption frequencies, and the Cr concentration in cord tissue was positively associated with indoor coal burning. In conclusion, prenatal Cr exposure is a risk factor for OFCs, and indoor coal burning during pregnancy may be one of the sources of Cr exposure.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.envres.2022.113799&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2009 ItalyPublisher:Oxford University Press (OUP) Authors: Micheletti, Cristian; ORLAND H.;Abstract Motivation: The steady growth of the number of available protein structures has constantly motivated the development of new algorithms for detecting structural correspondences in proteins. Detecting structural equivalences in two or more proteins is computationally demanding as it typically entails the exploration of the combinatorial space of all possible amino acid pairings in the parent proteins. The search is often aided by the introduction of various constraints such as considering protein fragments, rather than single amino acids, and/or seeking only sequential correspondences in the given proteins. An additional challenge is represented by the difficulty of associating to a given alignment, a reliable a priori measure of its statistical significance. Results: Here, we present and discuss MISTRAL (Multiple STRuctural ALignment), a novel strategy for multiple protein alignment based on the minimization of an energy function over the low-dimensional space of the relative rotations and translations of the molecules. The energy minimization avoids combinatorial searches and returns pairwise alignment scores for which a reliable a priori statistical significance can be given. Availability: MISTRAL is freely available for academic users as a standalone program and as a web service at http://ipht.cea.fr/protein.php. Contact: michelet@sissa.it Supplementary information: Supplementary data are available at Bioinformatics online.
Bioinformatics arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eumore_vert Bioinformatics arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/bioinformatics/btp506&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 1986add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=2941211&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=2941211&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint , Journal 2018 ChilePublisher:PeerJ Dominique Alò; Dominique Alò; Andrea Castillo; Horacio Samaniego; Benito A. González;Background The main goal of this contribution was to define the ecological niche of the guanaco (Lama guanicoe), to describe potential distributional changes, and to assess the relative importance of niche conservatism and divergence processes between the two lineages described for the species (L.g. cacsilensis and L.g. guanicoe). Methods We used maximum entropy to model lineage’s climate niche from 3,321 locations throughout continental Chile, and developed future niche models under climate change for two extreme greenhouse gas emission scenarios (RCP2.6 and RCP8.5). We evaluated changes of the environmental niche and future distribution of the largest mammal in the Southern Cone of South America. Evaluation of niche conservatism and divergence were based on identity and background similarity tests. Results We show that: (a) the current geographic distribution of lineages is associated with different climatic requirements that are related to the geographic areas where these lineages are located; (b) future distribution models predict a decrease in the distribution surface under both scenarios; (c) a 3% decrease of areal protection is expected if the current distribution of protected areas is maintained, and this is expected to occur at the expense of a large reduction of high quality habitats under the best scenario; (d) current and future distribution ranges of guanaco mostly adhere to phylogenetic niche divergence hypotheses between lineages. Discussion Associating environmental variables with species ecological niche seems to be an important aspect of unveiling the particularities of, both evolutionary patterns and ecological features that species face in a changing environment. We report specific descriptions of how these patterns may play out under the most extreme climate change predictions and provide a grim outlook of the future potential distribution of guanaco in Chile. From an ecological perspective, while a slightly smaller distribution area is expected, this may come with an important reduction of available quality habitats. From the evolutionary perspective, we describe the limitations of this taxon as it experiences forces imposed by climate change dynamics.
PeerJ Preprints arrow_drop_down PeerJ PreprintsPreprint . 2018License: CC BYFull-Text: https://peerj.com/preprints/3517.pdfData sources: PeerJ PreprintsPeerJ PreprintsPreprint . 2018License: CC BYFull-Text: https://peerj.com/preprints/3517v1.pdfData sources: PeerJ PreprintsUniversidad de Chile: Repositorio académicoArticle . 2018License: CC BY NC NDData sources: Bielefeld Academic Search Engine (BASE)https://doi.org/10.7287/peerj....Article . 2018 . Peer-reviewedLicense: CC BYData sources: CrossrefPontificia Universidad Católica de Chile: Repositorio UCArticle . 2020Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7717/peerj.4907&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert PeerJ Preprints arrow_drop_down PeerJ PreprintsPreprint . 2018License: CC BYFull-Text: https://peerj.com/preprints/3517.pdfData sources: PeerJ PreprintsPeerJ PreprintsPreprint . 2018License: CC BYFull-Text: https://peerj.com/preprints/3517v1.pdfData sources: PeerJ PreprintsUniversidad de Chile: Repositorio académicoArticle . 2018License: CC BY NC NDData sources: Bielefeld Academic Search Engine (BASE)https://doi.org/10.7287/peerj....Article . 2018 . Peer-reviewedLicense: CC BYData sources: CrossrefPontificia Universidad Católica de Chile: Repositorio UCArticle . 2020Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7717/peerj.4907&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2020Publisher:MDPI AG Lei Feng; Jiejie Sun; Yuanbao Shi; Guibin Wang; Tongli Wang;Camptotheca acuminata is considered a natural medicinal plant with antitumor activity. The assessment of climate change impact on its suitable habitats is important for cultivation and conservation. In this study, we applied a novel approach to build ecological niche models with both climate and soil variables while the confounding effects between the variables in the two categories were avoided. We found that the degree-days below zero and mean annual precipitation were the most important climatic factors, while the basic soil saturation, soil gravel volume percentage, and clay content were the main soil factors, determining the suitable habitats of C. acuminata. We found that suitable habitats of this species would moderately increase in future climates under both the RCP4.5 and RCP8.5 climate change scenarios for the 2020s, 2050s, and 2080s. However, substantial shifts among levels of habitat suitability were projected. The dual high-suitable habitats would expand, which would be favorable for commercial plantations. Our findings contribute to a better understanding of the impact of climate change on this species and provide a scientific basis for the cultivation and conservation purposes.
Forests arrow_drop_down ForestsOther literature type . 2020License: CC BYFull-Text: http://www.mdpi.com/1999-4907/11/8/891/pdfData sources: Multidisciplinary Digital Publishing Instituteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/f11080891&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert Forests arrow_drop_down ForestsOther literature type . 2020License: CC BYFull-Text: http://www.mdpi.com/1999-4907/11/8/891/pdfData sources: Multidisciplinary Digital Publishing Instituteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/f11080891&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 1982Publisher:Informa UK Limited S.H. Harmon; Leroy B. Yeatts; T.K. Rao; G. M. Henderson; John E. Caton; Wayne H. Griest;pmid: 6757160
Post-electrostatic precipitator (ESP) fly ash samples were collected from a coal-fired electric power generation plant under three modes of plant operation: normal operation, a low NOx-emission mode of combustion, and operation with the ESP shorted-out. Results of chemical and physical characterization of the ashes were compared with bacterial mutagenicity bioassay to determine parameters or compounds correlating with bioactivity. The general physical properties, ultimate composition, and trace elemental and radiochemical species determined did not correlate with the mutagenicity. Only the presence of aromatic hydrocarbons and chemically derivatizable polar organic compounds appeared to be associated with mutagenicity of the fly ash.
International Journa... arrow_drop_down International Journal of Environmental & Analytical ChemistryArticle . 1982 . Peer-reviewedData sources: CrossrefInternational Journal of Environmental & Analytical ChemistryArticle . 1983Data sources: Europe PubMed CentralInternational Journal of Environmental & Analytical ChemistryJournalData sources: Microsoft Academic Graphadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/03067318208078331&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert International Journa... arrow_drop_down International Journal of Environmental & Analytical ChemistryArticle . 1982 . Peer-reviewedData sources: CrossrefInternational Journal of Environmental & Analytical ChemistryArticle . 1983Data sources: Europe PubMed CentralInternational Journal of Environmental & Analytical ChemistryJournalData sources: Microsoft Academic Graphadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/03067318208078331&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2016Publisher:Ivyspring International Publisher Funded by:NIH | DISEASE MODELING OF ALCOH...NIH| DISEASE MODELING OF ALCOHOL RELATED HEPATOCELLULAR CARCINOMA USING PATIENT IPSCSAuthors: Yoon Young Jang; Abhijeet Deshmukh; Lipeng Tian; Neha Prasad;Alcohol consumption has long been a global problem affecting human health, and has been found to influence both fetal and adult liver functions. However, how alcohol affects human liver development and liver progenitor cells remains largely unknown. Here, we used human induced pluripotent stem cells (iPSCs) as a model to examine the effects of alcohol, on multi-stage hepatic cells including hepatic progenitors, early and mature hepatocyte-like cells derived from human iPSCs. While alcohol has little effect on endoderm development from iPSCs, it reduces formation of hepatic progenitor cells during early hepatic specification. The proliferative activities of early and mature hepatocyte-like cells are significantly decreased after alcohol exposure. Importantly, at a mature stage of hepatocyte-like cells, alcohol treatment increases two liver progenitor subsets, causes oxidative mitochondrial injury and results in liver disease phenotypes (i.e., steatosis and hepatocellular carcinoma associated markers) in a dose dependent manner. Some of the phenotypes were significantly improved by antioxidant treatment. This report suggests that fetal alcohol exposure may impair generation of hepatic progenitors at early stage of hepatic specification and decrease proliferation of fetal hepatocytes; meanwhile alcohol injury in post-natal or mature stage human liver may contribute to disease phenotypes. This human iPSC model of alcohol-induced liver injury can be highly valuable for investigating alcoholic injury in the fetus as well as understanding the pathogenesis and ultimately developing effective treatment for alcoholic liver disease in adults.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7150/ijbs.15811&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7150/ijbs.15811&type=result"></script>'); --> </script>
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