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Introduction: The current economic, social and environmental problems faced by society are some of the most emerging concerns of the main governmental institutions. In this sense, Education for Sustainable Development and integration of the Sustainable Development Goals (SDGs) into the education system seems to be a key link for its mitigation. Within education, physical education (PE) could provide positive synergy and contribute to achieve the SDGs. However, the relationship between PE and Sustainable Development is still in its nascent stage. Objective: Overall, we aim to explore the ways in which the literature has addressed the SDGs and PE. To this end, this scoping review has two objectives. The first is to provide a synthesis of the research to date on PE and the SDGs, presenting the results in terms of the types of literature, methods, samples, provenance of authorship and the main findings. The second is to investigate which specific SDGs and targets have appeared most frequently in research within the field of PE. Method: Due to the emergent nature of the topic under examination, we present a scoping review. After identifying the parameters to be analysed, we redefined the topic of study. We applied a number of criteria and selected relevant studies the introduction of the SDGs (2015) until June 2022. We searched Web of Science, SPORTdiscus, Scopus, Google Scholar and PROquest using words such as ‘Sustainable Development’, ‘SDGs’ and ‘PE’. Results and discussion: We reviewed 22 papers that met the inclusion criteria. We noted several characteristics in these studies. Most studies published between 2015 and 2022 come from international institutions (Commonwealth, UNESCO, etc.), and critical view articles, which theorise about the potential relation between PE and the SDGs. Beginning in 2021, there has been much more empirical research, mainly in the form of qualitative and quantitative cross-sectional studies. Most of this empirical research has been developed with undergraduate students in Physical Education Teacher Education (PETE). Some researchers have used pedagogical models such as service learning and cooperative learning as valid didactic tools to work on the SDGs. On the other hand, the countries that seem to show the greatest interest in research on the SDGs and PE are European, especially Spain and Sweden. Finally, SDGs 3 (Health and Wellbeing), 4 (Quality-Education) and 5 (Gender-Equality) have the greatest relationship with PE, specifically target 4.5 on inclusion and equity, target 5.1 to avoid discrimination based on sex and target 3.6 concerning physical and mental health. Conclusions: The relationship between PE and the SDGs is an emerging topic. While papers published within the five years after definition of the SDGs have a strong theoretical character, empirical research has begun to predominate since 2021. The focus of future research should be to deepen the ways in which PE can contribute to the SDGs (pedagogical perspectives, content, objectives …). Researchers should use practice-based models to look for more sustainability-related content and, above all, to try to get students to reflect on how their daily actions can contribute to a more sustainable and durable world. This work was supported by ODSEF PROJECT. Design and implementation of the Sustainable Development Goals for Physical Education (University of Alicante) [REDES ICE-2021-5489].

Micropollutant removal in an algal treatment system fed with source separated wastewater streams was studied. Batch experiments with the microalgae Chlorella sorokiniana grown on urine, anaerobically treated black water and synthetic urine were performed to assess the removal of six spiked pharmaceuticals (diclofenac, ibuprofen, paracetamol, metoprolol, carbamazepine and trimethoprim). Additionally, incorporation of these pharmaceuticals and three estrogens (estrone, 17β-estradiol and ethinylestradiol) into algal biomass was studied. Biodegradation and photolysis led to 60-100% removal of diclofenac, ibuprofen, paracetamol and metoprolol. Removal of carbamazepine and trimethoprim was incomplete and did not exceed 30% and 60%, respectively. Sorption to algal biomass accounted for less than 20% of the micropollutant removal. Furthermore, the presence of micropollutants did not inhibit C. sorokiniana growth at applied concentrations. Algal treatment systems allow simultaneous removal of micropollutants and recovery of nutrients from source separated wastewater. Nutrient rich algal biomass can be harvested and applied as fertilizer in agriculture, as lower input of micropollutants to soil is achieved when algal biomass is applied as fertilizer instead of urine.

Signals relayed through G protein-coupled receptors (GPCR) play pivotal roles in human physiology and are important drug targets. About 40% of all GPCRs couple to the heterotrimeric G protein Gq. Biochemical studies as well as crystallography have improved our understanding of GqPCRs and their downstream partners. Here we focus on the "functional imaging" tools that have been developed to visualize, dissect and quantify signalling processes at the single living cell level. We provide an overview of the most important developments in readout of signalling by FRET and BRET, as well as of the labelling strategies commonly used to visualize proteins in living cells. In addition, tools that allow manipulation of individual steps, including chemically inducible dimerization and optogenetic tools are covered. Together, these developments will provide unprecedented insights in GqPCR signalling in living cells and model organisms.

The purpose of this study was to resolve the question of whether various selenium concentrations affect the ability of eight species, members of five genera, to produce mycelium biomass and absorb this trace element during submerged cultivation in Na2SeO3-enriched medium. The obtained results demonstrated the ability of mycelia of all of the tested species to absorb selenium at analyzed concentrations. Thus, selenium content ranged from 1.4 µg g-1 (Pleurotus eryngii) to 20.3 µg g-1 (Pleurotus ostreatus). The potential of mycelia to absorb selenium was significant, ranging from 8.1% (Lenzites betulinus) to 62.5% (P ostreatus) of its content in the medium. It may be concluded that all tested mushroom species could be used as satisfactory selenium sources due to the fact that the absorbed concentrations ranged from 15.8% (P. eryngii) to 36.9% (P. ostreatus) of the dietary selenium amount (55 µg d-1) recommended by the European Scientific Committee on Food.

The maxillofacial region is by far the most frequently selected target in assaults on adults. There is a causal link between alcohol intoxication and injury. Therefore, oral and maxillofacial surgery is, in effect, the lead speciality for those injured in violence and has a responsibility to orchestrate holistic care that takes into account mental health needs. Recent years have also seen a determined effort by oral and maxillofacial surgeons to get involved in wider issues of prevention, exemplified by the national UK BAOMS Facial Injuries Awareness Week. Multi-agency prevention, not just with mental health professionals in the case of individual patients, but also with emergency medicine, public health, local government, the police and the voluntary sector is key to success. Given the potential complexity of collaborations like this, it is important to understand what works in multi-agency prevention. This paper reviews successful interventions: their rationale and how oral and maxillofacial surgeons can contribute to local injury prevention.

AbstractAlcohol (ethanol) use is almost normative by late adolescence, in most western countries. It is important to identify factors that distinguish those who progress from alcohol initiation to sustained use of the drug, from those that keep a controlled pattern of drinking. The factors precipitating this transition may change across development. This study analyzed associations between behavioral endophenotypes and ethanol intake at three developmental periods. Exp. 1 measured ethanol drinking at postnatal day 18, via an intraoral infusion procedure, in male or female pre‐weanling rats screened for anxiety response in the light‐dark box test and for distance traveled in a novel open field. Exp. 2 measured, in juvenile/adolescent or young adult rats, the association between shelter seeking, exploratory/risk‐taking behaviors, anxiety or hedonic responses, and ethanol intake. Ethanol intake in pre‐weanlings was explained by distance traveled in a novel environment, whereas anxiety responses, measured in the multivariate concentric square field apparatus (MSCF), selectively predicted ethanol intake at adolescence, but not at adulthood. Those juvenile/adolescents with lower mean duration of visit to areas of the MSCF that evoke anxiogenic responses exhibited heightened ethanol intake. These findings suggest that the association between anxiety and ethanol intake may be specifically relevant during adolescence.

Abstract:  The beneficial effect of the ‘1‐drink‐a‐day’ lifestyle is suggested by studies of cardiovascular health, and this recommendation is increasingly followed in many countries. The main objective of this study was to determine whether this pattern of ethanol use would be detrimental to a pregnant woman. We exposed a primary culture of rat cerebellum from embryonic day 17 (corresponding to second trimester in humans) to ethanol at a concentration of 17.6 mM which is roughly equivalent to one glass of wine. Acutely, there was no change in cell viability after 5 or 8 days of exposure relative to control. By 11 days, a reduction in the number of viable cells was observed without an accompanying change in caspase‐3 activity (marker of apoptotic cell death), suggesting changes in cell proliferation. As the proportion of nestin‐positive cells was higher in the ethanol‐treated cultures after 5 days, we hypothesized that an increase in differentiation to neurons would compensate for the ongoing neuronal death. However, there were limits to this compensatory ability as the relative proportion of nestin‐positive cells was decreased after 11 days. To further illustrate the negative long‐term effects of this ethanol dose, cultures were exposed for 30 days. After this period, virtually no neurons or myelinating oligodendrocytes were present in the ethanol‐treated cultures. In conclusion, chronic exposure to ethanol, even at small doses, dramatically and persistently affects normal development.

Previous studies have shown that both 3-amino-1,2,4-triazole (AT), which inhibits metabolism of ethanol (EtOH) to acetaldehyde by inhibiting catalase, and D-penicillamine (D-P), an acetaldehyde-sequestering agent, modulate EtOH-conditioned place preference (CPP) in male albino Swiss (IOPS Orl) mice. These studies followed a reference-dose-like procedure, which involves comparing cues that have both been paired with EtOH. However, the role of EtOH-derived acetaldehyde has not been examined using a standard CPP method, and efficacy of these treatments could be different under the two circumstances. In the present investigation, we manipulated the strength of CPP across five separate studies and evaluated the effect of D-P and AT on EtOH-induced CPP following a standard unbiased CPP procedure. Mice received pairings with vehicle-saline injections with one cue and, alternatively, with AT- and D-P-EtOH with another cue. Our studies indicate that AT and D-P only disrupt CPP induced by EtOH in mice when the number of conditioning sessions and the dose of EtOH are low. These findings suggest that acquisition of EtOH-induced CPP may depend on the levels of acetaldehyde available during memory acquisition and the strength of the memory. Therefore, we propose that, at least when the memory processes are labile, brain acetaldehyde could participate in the formation of Pavlovian learning elicited by EtOH.