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The latest information from Hiroshima and Nagasaki on radiation-induced cancer in man includes new DS86 dose assignments and extension of the Life-Span Study Sample cohort through 1985. The implications of these new doses and updated data for the assessment of cancer risk at low to moderate doses have been evaluated. Results from the fitting of three dose-response models (linear, quadratic, linear-quadratic) to the data at doses less than 1.5 Gy are reported. Based on statistical analyses of the authors' results, comments are made concerning the possible shapes of dose-response curves for human cancer.

Abstract The oxidation characteristics of several small methyl and ethyl esters with carbon number less than six were investigated in laminar flames. The kinetics of such fuels are subsets of those of larger alkyl esters that are constituents of practical biodiesel fuels. A total of seven fuels, namely methyl formate, methyl acetate, methyl propionate, methyl butanoate, ethyl formate, ethyl acetate, and ethyl propionate were considered. Experiments were conducted at atmospheric pressure, elevated reactant temperatures, and over a wide range of equivalence ratios. Laminar flame speeds were determined in the counterflow configuration in which flow velocities were measured using particle image velocimetry. Several detailed kinetic models were tested against the experimental data, and insight was provided into the high-temperature combustion kinetics of the aforementioned fuels. Based on comparisons between experimental and computed results it became apparent that the chemistry of alkyl-ester combustion chemistry is evolving and much needs to be done in order to derive improved rate constants for a wide range of elementary steps.

Abstract The Seed-and-Blanket (SB it is few percent higher than that of the 2-stage PWR-ABR system. Approximately 7% of the thorium fed to the blanket is converted into energy, which makes the thorium fuel utilization approximately 12 times the utilization of natural uranium in PWRs. A comprehensive fuel cycle evaluation performed with the methodology developed by the recent U.S Department of Energy’s Nuclear Fuel Cycle Evaluation and Screening campaign concludes that the PWR-S&B system has similar fuel cycle performance characteristics as the PWR-ABR system. The S&B concept may potentially feature improved economics and resource utilization relative to the ABR.

We present the first calculations to follow the evolution of all stable isotopes (and their abundant radioactive progenitors) in a finely zoned stellar model computed from the onset of central hydrogen burning through explosion as a Type II supernova. The calculations were performed for a 15 solar mass Pop I star using the most recently available set of experimental and theoretical nuclear data, revised opacity tables, and taking into account mass loss due to stellar winds. We find the approximately solar production of proton-rich isotopes above a mass number of A=120 due to the gamma-process. We also find a weak s-process, which along with the gamma-process and explosive helium and carbon burning, produces nearly solar abundances of almost all nuclei from A=60 to 85. A few modifications of the abundances of heavy nuclei above mass 90 by the s-process are also noted and discussed. New weak rates lead to significant alteration of the properties of the presupernova core. 10 pages, 4 figures, Nuclear Astrophysics X Workshop proceedings

Accelerators for heavy-ion inertial fusion energy (HIF) have an economic incentive to fit beam tubes tightly to beams, putting them at risk from electron clouds produced by emission of electrons and gas from walls. Theory and PIC simulations suggest that the electrons will be radially trapped in the /spl ges/1 kV ion-beam potential. We are beginning studies on the High-Current Experiment (HCX) with unique capabilities to characterize electron production and trapping, the effects on ion beams, and mitigation techniques. We are measuring the flux of electrons and gas evolved from a target, whose angle to the beam can be varied between 78/spl deg/ and 88/spl deg/ from normal incidence. Quadrupole magnets are operating with a variety of internal charged particle diagnostics to measure the beam halo loss, net charge, electron ionization rate, and gas density.

The operation of a building connects the building, its performance and its end-users. When a mismatch occurs between users' expectations and operations processes, then complaints can arise. The use of enhanced complaint handling processes is investigated to ascertain whether this can help diagnose performance problems. Two LEED Platinum-rated office buildings form the basis for a case study of the components that make up an enhanced complaint handling process. Some of the social dynamics of complaints in buildings are consequently discussed. It is found that an enhanced complaint handling approach could contribute to a form of ongoing commissioning that goes beyond primarily reactive or dismissive treatments of complaints. Le fonctionnement d'un immeuble etablit des rapports entre l'immeuble, ses performances et ses utilisateurs finaux. Lorsqu'un decalage se produit entre les attentes des utilisateurs et les processus d'exploitation, des plaintes peuvent alors s'elever. L'utilisation de processus ameliore...

We assessed the physical, chemical and toxicological characteristics of particulate emissions from four light-duty gasoline direct injection vehicles when operated over the LA92 driving cycle. Our results showed that particle mass and number emissions increased markedly during accelerations. For three of the four vehicles tested, particulate matter (PM) mass and particle number emissions were markedly higher during cold-start and the first few accelerations following the cold-start period than during the hot running and hot-start segments of the LA92 cycle. For one vehicle (which had the highest emissions overall) the hot-start and cold-start PM emissions were similar. Black carbon emissions were also much higher during the cold-start conditions, indicating severe fuel wetting leading to slow evaporation and pool burning, and subsequent soot formation. Particle number concentrations and black carbon emissions showed large reductions during the urban and hot-start phases of the test cycle. The oxidative potential of PM was quantified with both a chemical and a biological assay, and the gene expression impacts of the PM in a macrophage model with PCR (polymerase chain reaction) and ELISA (enzyme-linked immunosorbent assay) analyses. Inter- and intra-vehicle variability in oxidative potential per milligram of PM emitted was relatively low for both oxidative assays, suggesting that real-world emissions and exposure can be estimated with distance-normalized emission factors. The PCR response from signaling markers for oxidative stress (e.g., NOX1) was greater than from inflammatory, AhR (aryl hydrocarbon receptor), or MAPK (mitogen-activated protein kinase) signaling. Protein production associated with inflammation (tumor necrosis factor alpha-TNFα) and oxidative stress (HMOX-1) were quantified and displayed relatively high inter-vehicle variability, suggesting that these pathways may be activated by different PM components. Correlation of trace metal concentrations and oxidative potential suggests a role for small, insoluble particles in inducing oxidative stress.

Humans are exposed to complex mixtures of phthalates. Gestational exposure to phthalates has been linked to preeclampsia and preterm birth through potential pathways such as endocrine disruption, oxidative stress, and inflammation. Eicosanoids are bioactive signaling lipids that are related to a variety of homeostatic and inflammatory processes. We investigated associations between urinary phthalates and their mixtures with plasma eicosanoid levels during pregnancy using the PROTECT cohort in Puerto Rico (N = 655). After adjusting for covariates, we estimated pair-wise associations between the geometric mean of individual phthalate metabolite concentrations across pregnancy and eicosanoid biomarkers using multivariable linear regression. We used bootstrapping of adaptive elastic net regression (adENET) to evaluate phthalate mixtures associated with eicosanoids and subsequently create environmental risk scores (ERS) to represent weighted sums of phthalate exposure for each individual. After adjusting for false-discovery, in single-pollutant analysis, 14 of 20 phthalate metabolites or parent compound indices showed significant and primarily negative associations with multiple eicosanoids. In our mixture analysis, associations with several metabolites of low molecular weight phthalates - DEP, DBP, and DIBP - became prominent. Additionally, MEHHTP and MECPTP, metabolites of a new phthalate replacement, DEHTP, were selected as important predictors for determining the concentrations of multiple eicosanoids from different pathway groups. A unit increase in phthalate ERS derived from bootstrapping of adENET was positively associated with several eicosanoids mainly from Cytochrome P450 pathway. For example, an increase in ERS was associated with 11(S)-HETE (β = 1.6, 95% CI: 0.020, 3.180), (±)11,12-DHET (β = 2.045, 95% CI: 0.250, 3.840), 20(S)-HETE (β = 0.813, 95% CI: 0.147, 1.479), and 9 s-HODE (β = 2.381, 95% CI: 0.657, 4.104). Gestational exposure to phthalates and phthalate mixtures were associated with eicosanoid levels during pregnancy. Results from the mixture analyses underscore the complexity of physiological impacts of phthalate exposure and call for further in-depth studies to examine these relationships.