• Energy Research
• 2025-2025close
• Closed Access close
• Restricted close
• Embargo close

The Space Radiobiological Exposure Facility (SREF) is a general experimental facility at the China Space Station for scientific research in the fields of space radiation protection, space radiation biology, biotechnology, and the origin of life. The facility provides an environment with controllable temperatures for experiments with organic molecules and model organisms such as small animals, plant seeds, and microorganisms. The cultivation of small animals can be achieved in the facility with the use of microfluidic chips and images and videos of such experiments can be captured by microscopy. SREF also includes a linear energy transfer (LET) detector, neutron detectors, and a solar ultraviolet (UV) detector to measure the LET spectrum of the charged particles, energy spectrum and dose equivalent of neutrons, and fluence of solar UV radiation, respectively. The facility is reusable, and the model organisms from the first exposure experiment were recovered in orbit and returned to the ground for further study.

Purpose Due to new regulations, changing customer preferences and strategic reorientation, the role of responsible decision-making has become increasingly complex for both small and large firms. In relation to this, this article contends that companies are turning into political actors with political responsibility for sustainability-related issues in their supply chain and beyond. Therefore, this article aims to investigate (1) how companies have become political in their supply chain and (2) which mechanisms contribute to this development. Design/methodology/approach To investigate the political nature of companies in their supply chain, this research draws on a critical realist case study inspired by process tracing. A total of 30 interviews were conducted with actors from within global coffee supply chains to get a wide overview of the different perspectives on how coffee companies deal with political complexity. Findings It is found that companies in the coffee supply chain are increasingly acting like traditional political actors. Their engagement in political activities emphasizes three contextualized causal mechanisms driving this transformation: (1) customer pressure, (2) attention to trust and transparency and (3) personal motivation. Research limitations/implications The results point to the political nature of companies’ supply chain management (SCM)-related activities, indicating they should recognize that their role in the supply chain gives them the capacity to act as state-like actors. Originality/value Political SCM is introduced as a new conceptual element in the SCM discourse by defining the term “political” and linking political theory and sustainable SCM literature. This provides a better understanding of SCM and offers guidance on how SCM can be understood as a set of political activities.

Hydrogels made of plant-derived biomass have gained popularity in biomedical applications because they are frequently affordable, readily available, and biocompatible. Finding the perfect plant-derived biomass-based hydrogels for biomedicine that can replicate essential characteristics of human tissues in regard to structure, function, and performance has proved to be difficult. In this review, we summarize some of the major contributions made to this topic, covering basic ideas and different biomass-based hydrogels made of cellulose, hemicellulose, and lignin. Also included is an in-depth discussion regarding the biosafety and toxicity assessments of biomass-based hydrogels. Finally, this review also highlights important scientific debates and major obstacles regarding biomass-based hydrogels for biomedical applications.

N6-methyladenosine (m6A) plays a role in the development of tumors. However, the specific role of VIRMA, an RNA methyltransferase, in pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study shows that VIRMA expression is elevated in PDAC. Increased VIRMA levels promoted PDAC growth and spread, while reducing VIRMA expression slowed these processes. VIRMA facilitated SLC43A2 mRNA degradation through an m6A-YTHDF2 pathway. The resulting decrease in SLC43A2 reduced phenylalanine absorption and oxidative stress, further driving PDAC progression. Furthermore, alcohol increased C/EBP β expression, which bound to VIRMA's promoter, enhancing its transcription. These findings suggest a connection between alcohol consumption, m6A modifications, and phenylalanine absorption in PDAC progression, offering a new approach to combat this disease.