SystR will propose a groundbreaking approach to feed the science-policy nexus with innovative solutions to address systemic risks (interconnection between multiple sectors and stakeholders and resulting cascading climate impacts). This approach will accelerate transformative adaptation and avoid maladaptation by breaking silos, harmonising multiple scales of governance and tailoring solutions to local needs and strengths with Smart Specialisation Strategies. SystR will deliver a set of innovative results that will collectively strengthen the systemic resilience of the 6 multi-scale regions and communities involved and have a long lasting impact: 1. An Adaptation Support tool targeting the process of systemic adaptation based on the P2R project Regional Resilience Journey 2. A Community Empowerment framework for actively mobilising a diversity of actors across the value chain into the development and testing of transformative solutions, fit to address local climate and aggravating systemic vulnerabilities and risks 3. Novel systemic Governance schemes to improve cooperation at multiple scales 4. Coherent Financial roadmaps to determine how to finance identified resilience solutions and strategies 5. Design, with the support of the digital Visualisation tools, and implement Integrated Ecosystem of Resilience Solutions, integrating the cross sectorial enabling and systemic physical solutions including NBS 6. Accelerate the uptake of its results for critical mass creation, through the Upscaling toolbox and the One Stop Shop, the SystR’s results aggregator. Overall, while pursuing close collaboration with the Climate Adaptation Mission, SystR will demonstrate systemic resilience in three contexts most representative of Europe: coastal in Guadeloupe-France, rural in Bystrica-Slovakia and urban in Rome-Italy, which will be twinned with replication sites of similar challenges, Galicia, Strasbourg and Egaleo, respectively.