VITAL will deliver a comprehensive clinically validated multi-scale, multi-organ modelling platform that is driven by and can represent individual patient data acquired, both in the clinic and from wearable technology. The platform will create a virtual human twin for individualised and sex-specific optimisation of medical (pharmacological) or surgical (interventional) therapy for complex, multifactorial cardiovascular disorders that have systemic impact and high risk of comorbidities of a.o. the kidney and brain: systemic hypertension, heart failure (with/without preserved ejection fraction) and hemodynamically complicated atrial septal defects. User-friendly interfaces, co-created with healthcare professionals, will provide access to the technology. The platform consolidates existing multi-scale and multi-organ models of the heart, lung and systemic circulation and their regulatory mechanisms, and advances the state-of-the art by incorporating currently missing biophysics-based, physiology-underpinned components (kidney-related blood pressure control, hormonal actions, vascular region-specific smooth muscle cell functionality, and cardiac and arterial growth and remodelling mechano-biological mechanisms). By the end of the project, the platform will have been validated and tested in more than 200 patients across 5 clinical studies in France and the UK to optimise the treatment of patients with resistant systemic hypertension, heart failure or atrial septum defects. A unique aspect of VITAL is its focus on monitoring the mental health of patients to understand their expectations and reservations towards digital health technology. VITAL technology will be compliant with and contribute directly to the VPHi and EDITH virtual twin ecosystem. This will further unlock the potential of new digital tools that intelligently combine the power of physics-based multi-scale models, artificial intelligence and data to provide better health care for all.

RealCare is a cutting-edge research initiative focused on developing and validating next-generation point-of-care (PoC) systems that detect essential biomarkers in human biofluids in real-time. These systems are designed to be compact, energy-efficient, and integrated with extended reality interfaces, with a specific emphasis on cancer and cardiac diseases in demanding clinical settings. RealCare's approach includes advanced biomarker detection technologies, such as microfluidics and new generations of microneedles, label-free electrochemical biosensors using 2D materials, optical sensors utilizing CRISPR, biological amplifiers combined with fluorescent microscopy, and scalable SPR with energy-efficient electronic readouts, AI data processing, and wireless communication units. Additionally, RealCare will design portable, interoperable, and adaptable PoC systems that integrate the biomarker detection technology with vital sign monitoring, including advanced data analytics and AI methods. The initiative also focuses on developing intuitive extended reality interfaces, such as augmented and virtual reality, to visualize biomarker data in real-time and facilitate rapid medical decision-making in integrated in-care environments and workflows. Rigorous clinical validation studies will be conducted in relevant clinical settings, including the surgery room, ICU, and patient's home, to ensure accuracy, reliability, usability, and impact on patient outcomes. RealCare places special attention on including a diverse patient population in their studies to validate the effectiveness of the developed systems. Data quality, interoperability, and medical data protection are key considerations in RealCare's strategy. Based on our unique PoC technological platform and our strong, multidisciplinary consortium partnership, we propose promising lab-to-market paths with the potential for significant societal impact.

This proposal aims at developing an advanced detection and ranging sensor system based on a collaborative scheme, integrating on the same module both radio and light-based sensing. The module will consist of: a silicon photonics solid-state light detection and ranging (LiDAR) chip, with integrated laser source and driver electronics; a CMOS radio detection and ranging (RADAR) chip connected to a single transmitting (Tx) and receiving (Rx) set of antennas; a processing unit (PU) to actively control the two sensors and process the generated data. The LiDAR and RADAR chip will be integrated on the same printed circuit board (PCB) avoiding any use of free space optics. The proposed architecture will allow an active cooperation of the two sensors through an advanced algorithm installed on the PU. CoRaLi-DAR advanced sensor system will exploit LiDAR’s high-resolution capabilities, and RADAR’s strong reliability in adverse weather conditions, to deliver an automotive compatible detection and ranging system. The use of fully integrated photonics and electronics will reduce packaging size, manufacturing cost and ultimately operational power. With CoRaLi-DAR we plan to create a low-cost, low power and reliable sensor system that can be used as a platform for the automotive market and beyond.

The AMANDA project aims to stretch the limits of Electronic Smart Systems’ (ESS) autonomy (in terms of energy, decision making & maintenance-free lifetime extension) and miniaturization (by applying high aspect ratio design architecture). Its ultimate goal is to develop and validate a cost-attractive next generation Autonomous Smart Sensing Card (ASSC) that will serve multi-sensorial IoT applications for smart living and working environments. More specifically, AMANDA ambitiously seeks to further strengthen the partners’ technological excellence by delivering the ASSC’s: energy autonomy booster (PV energy harvester, power management electronics and rechargeable storage); connectivity and tracking sub-system; processing unit (built-in intelligence); multi-sensing adaptable sub-system (CO2 sensor, imaging sensor, capacitive sensor, temperature sensor as well as additional off-the-self/ close-to-commercialisation sensors); and the encapsulation & packaging sub-system for high manufacturability. Furthermore, security by design mechanisms will be employed to ensure low vulnerability, user and device authentication, intrusion prevention & detection, and overall enhanced cyber-secure operation. 3 versions of the ASSC are anticipated (indoor, outdoor and wearable) that may be interconnected (swarm capabilities) and managed over the cloud. AMANDA’s ASSC will be validated at versatile use scenarios for applications in the context of smart cities (air quality monitoring through fleets of vehicles and asset tracking and surveillance/ object and people detection), smart homes (indoor air quality and comfort), smart workplaces (indoor comfort, occupancy & productivity) and industrial environments (health, safety and/or environmental monitoring during inspection activities). 8 partners (3 research & 5 industry) from 6 European countries will jointly undertake the proposed research and will deliver the envisaged technological breakthroughs to strengthen European leaderships in ESS.

The REMPOWER project embarks on a pioneering journey to harness the untapped potential of space-based solar power (SBSP) through innovative rectenna technology and sub-THz wireless energy transmission. However, SBSP also faces many challenges, such as high launch costs, technical difficulties, and potential safety and security issues. At its core, REMPOWER is driven by four pivotal technical objectives associated with the capture and rectification of a sub-THz high energy beam: 100 GHz Modular, Flexible and Lightweight Rectenna: REMPOWER will develop rectenna technologies capable of capturing energy at 100 GHz. These modular rectenna technologies will provide modularity, flexibility at panel level and will allow the reduction of the weight of the final solution. High Efficiency and high power rectification: REMPOWER’s advanced diode and rectifier modeling and design will allow tackling high rectification efficiency, and high power handling capability, despite the sub-THz constraint. This will yield high output DC power while limiting the cost related to the number of required non-linear devices. Nonlinear Rectifier and Rectenna Characterization: REMPOWER will introduce a novel approach by subjecting rectifiers to wideband signals, enabling a comprehensive analysis of amplitudes and phases across multiple intermodulation frequencies. This breakthrough will unveils intricate nonlinear behaviors for heightened efficiency. Scalable Rectenna Arrays for Large Surfaces: REMPOWER will focus on scalability to enable high-power transmission, to reduce design and manufacturing costs and to improve modularity and flexibility. The progress within REMPOWER transcends current technological boundaries, offering promise for sustainable in-space mobility solutions and renewable energy generation. By conquering the challenges of high-frequency energy capture, REMPOWER will reshape the future of space exploration, energy generation, and sustainability.