Increasing global competition for natural resources poses major challenges to the Arctic. ArcticHubs will develop sustainable solutions for reconciliation of competing livelihoods and land-use modes in key Arctic ‘hubs’—important socioeconomic nodes in a geographical network—and their surroundings, considering in particular the needs and cultures of local communities (incl. indigenous people). This will be achieved by applying multi- and interdisciplinary, multi-actor participatory approaches to systematically map, identify and analyse global drivers and pressures with high environmental, societal and economic impacts affecting 33 key hubs examining sustainability of fish farming, multiple use of forests, tourism, mining and indigenous cultures. The outcome of ArcticHubs will be the provision of solution-oriented tools, such as improved public participatory geographical information systems, guidelines for ‘social license to operate’, and future scenarios to Arctic communities, industrial stakeholders, decision- and policymakers, and other relevant actors. This will enable creation and implementation of regional development strategies that reconcile new economic opportunities with traditional livelihoods, and increase the resilience of both new and existing industries and livelihoods against environmental, economic and political changes in the Arctic. The impact of the project will be long-term sustainability and resilience of future environmental, socio-cultural, economic and political factors in the increasingly competitive and globalised Arctic, enhancing social acceptance of increased economic activity. These impacts will contribute to the implementation of the new integrated EU policy for the Arctic, IPPC assessments and other major regional and global initiatives, provide support to the EU Arctic Research Cluster, and enhance engagement of and interaction between local (incl. indigenous), national and global actors.