Over 50m people suffer from multimorbidity (PMM) in Europe. Recent reviews find that PMM experience a range of system and professional-related issues with care delivery. In part, this is because current investments in process-based delivery means delivering healthcare within single diagnoses tracks/silos. For PMMs this does not reflect real-world conditions. No technology is available today that enables the specific care, treatment, administration and support needed for this target group. Breakthrough solutions will classify the individual according to their co/multimorbidities and medications. But this needs to be developed in close dialogue between PMM, care providers and industry sectors based upon a strong demand driven approach in a PCP. Accordingly, the CareMatrix Buyers Group (SE, NO, ES) challenge the market to develop innovative technology that enables more predictive care and support benefits for PMM. This is achieved with 6 project objectives summarised as PCP: stakeholder engagement, roadmap, Call, implementation, next steps and; profiling and outreach via IFIC. The methodology can be summarised as PCP: framing actions (PCP preparation, use of UCD principles and practice); implementation actions (Phases 1-3 contract management, support, evaluation and testing) and Market Preparation actions (business development support for Phase 3 suppliers, standards, initial PPI preparation). Direct benefits include: • 20% reduction in time spent for visits to care facilities • Improvements from baseline in at least 75% of aspects of care as identified using PREM surveys • 50% fewer patient data-related incidents (increased patient safety) between organizations • No of clinical errors reduced by 30%; Underpinning the CareMatrix solution(s) with integrated innovation (supportive policy priorities, organisational and social innovations) will optimise the potential of those solutions to produce savings of 10% in health care expenditure for PMM.

There is wide evidence regarding the weak points of end-stage Chronic kidney disease (CKD) patients in hemodialysis, and they include three intervention aspects: exercise, nutrition and psychological support. Evidence shows that exercise for patients in hemodialysis results in increased survival rate, functional capacity, strength and health-related quality of life. Additionally, different studies have shown the benefits of psychological interventions and the positive effect of educational programs on nutritional care for patients in hemodialysis. Despite the well-known benefits of exercise, this kind of programs are not being implemented in the routine clinical care of hemodialysis patients. Thus, the GoodRENal project aims to promote healthy lifestyles among dialysis patients in a holistic approach that combines exercise, nutrition and psychological wellbeing plus cognitive functioning addressing adult learners. The project will develop a health virtual platform including these three dimensions of cares. In summary, the project outputs will be:1.A didactic content in a modular platform to create an educational program for integrated treatments in patients with dialysis, O12.A guideline to promote healthy lifestyles among dialysis patients for health care providers, IO23.A guideline to promote e healthy lifestyles among dialysis patients for patients and formal – non formal carers IO3.In addition, two multiplier events will be held in Valencia and Greece, joining healthcare professionals, patients in dialysis treatment, families of dialysis patients, formal and non-formal caregivers of dialysis patients, and institutional stakeholders, such as; policy-makers, public administrations, regional entities and officers involved. A learning activity is also arranged to teach participants about the use of the platform and its didactic content.To achieve these aims, the consortium has been composed by 8 partners coming from Spain, Greece, Sweden and Belgium. - Fundación Universitaria San Pablo CEU - FSP-CEU has a large track record in clinical research in the field of renal rehabilitation. They have implemented exercise programs for patients undertaking hemodialysis in different clinical centers in Valencia.- Skåne University Hospital- SUS and specifically the Department of Nephrology has extensive experience in Nephrology research comprising fields of exercise training.- Aristotle University of Thessaloniki organizes and coordinates exercise rehabilitation programs for patients with chronic kidney disease. Additionally, intradialytic renal rehabilitation programs are performed in the Renal Unit of AHEPA Hospital for CKD patients on dialysis- Katholieke Universiteit Leuven and its collaboration with the department of nephrology of the University Hospital Leuven have a large track record in both clinical and basic research at an international level. - Hospital de Manises, the Nephrology Service has extensive experience on patients with chronic hemodialysis treatment and its complications. The intra-dialysis exercise has been applied as combined aerobic exercise plus resistance with bicycles plus weights, and also through virtual reality. - Universitat de Valencia UVEG as partner has a strong experience in IT transfer knowledge, dissemination and exploitation.The Universitat de València is highly qualified in training activities thanks to the strong academic expertise of its staff. - Universitat Politècnica de València -UPV, the PhD in Computer Science José-Antonio Lozanol-Quilis from the UPV has specialized in the field of Virtual Reality (VR) applied to the treatment of Psychological.- Karolinska Institutet -KI and specifically the Baxter Novum is built on the unique opportunities for integrated (academia industry healthcare), translational (clinical research basic research) and collaborative (collaborations with other researchers in Novum, KI and all over the world) research at Novum, Karolinska Institutet.The expected impact on the patient’s dialysis treatment, healthcare providers and the formal or non-formal caregivers will be: i) treatment adherence with the virtual platform due to all the implicated parts are listened in the tool`s elaboration ii) to cover over the patients and carers needs of health advice and including a usefulness treatment iii) Acquire an integrated treatment (exercise, nutrition and psychology) iv) Acquire a friendly tools for learning v) Achieve an adult education of healthcare providers and caregivers contributing to remove barriers of multimodal treatment, and consequently, ensure transferability to the clinical practice and the routine of health care professionals in the haemodialysis unit.At European level the project will promote the creation of a wide transnational community of dialysis patients and healthcare professionals with different background and experiences to shared it between all the mentioned community.

The European Rare Diseases Research Alliance (ERDERA) aims to improve the health and well-being of the 30 million people living with a rare disease in Europe, by making Europe a world leader in Rare Disease (RD) research and innovation, to support concrete health benefits to rare disease patients, through better prevention, diagnosis and treatment. This Partnership will deliver a RD ecosystem that builds on the successes of previous programmes by supporting robust patient need-led research, developing new diagnostic methods and pathways, spearheading the digital transformational change connecting the dots between care, patient data and research, while ensuring strong alignment of strategies in RD research across countries and regions. Structuring goal-oriented public-private collaborations targeted at interventions all along the R&D value chain will ensure that the journey from knowledge to patient impact is expedited, thereby optimising EU innovation potential in RD. To support its ambition and missions ERDERA has been designed as a comprehensive and integrated ecosystem of which structure can be compared to an institute encompassing three main parts: (i) funding, (ii) internal (in house) Clinical Research Network that implements research activities targeting clinical trial readiness of RDs and accelerating diagnosis and translation of research discovery into improved patient care, and (iii) related supporting services (Data, Expertise, Education and Training) as well as an acceleration hub that serve external and internal RD community, all supported by all-embracing coordination and strategy and foundational (inter)national alignment.