With Colorectal Cancer (CRC) being accountable for 12.4% of all deaths due to cancer, and with only 14% of EU citizens participating in screening programmes, there is an urgent need for accurate, non-invasive, cost-effective screening tests based on novel technologies and an increased awareness on the disease and its detection. Furthermore, personalized approaches for screening are needed, to consider genetic and other socioeconomic variables and environmental stressors that lead to different onsets of the disease. ONCOSCREEN responds to these challenges by developing a risk-based, population-level stratification methodology for CRC, to account for genetic prevalence, socio-economic status, and other factors. It complements this methodology by a) developing a set of novel, practical, and low-cost screening technologies with high sensitivity and specificity, b) leveraging AI to improve existing methodologies for CRC screening, allowing for the early detection of polyps and provision of a personalized risk status stratification, and c) providing a mobile app for self-monitoring and CRC awareness raising. Furthermore, ONCOSCREEN develops an Intelligent Analytics dashboard for policy makers facilitating effective policy making at regional and national levels. Through a multi-level campaign, the above-mentioned solutions are tested and validated. For the clinical solutions specifically, a clinical validation study has been planned with the participation of 4100 enrolled patients/citizens. To ensure the adoption of the developed solutions by the healthcare systems, their cost-effectiveness and financial viability will be assessed. The 48-months duration project will be implemented by a multidisciplinary consortium comprising of 38 partners, including technical solutions providers, hospitals, Ministries of Health as policy makers, legal and ethics experts, Insurance companies, involving actively end-users/citizens in all phases of implementation through targeted workshops. This action is part of the Cancer Mission cluster of projects on ‘Prevention, including Screening.

Manufacturing and logistics companies are subject to unforeseen events that disrupt the supply chain, causing production slowdowns, reduced output, and increased costs, making it difficult to meet customer demand. To mitigate these risks, manufacturers must build resilience across entire value chains. NARRATE will develop a sophisticated tool using AI, Digital Twin, and IoT technologies allowing end-to-end visibility and control over supply chain operations to monitor and predict potential disruptions, enabling supply chains to achieve improved resilience. The Intelligent Manufacturing Custodian (IMC) will leverage data from various production sources to enable proactive decision-making and act as a nerve centre for a supply-chain network, providing real-time monitoring and coordination of intelligent production processes and logistics. Integrating an IMC into a supply-chain will evolve its operations into Smart Manufacturing Network (SMN): a connected and self-orchestrated ecosystem linked end-to-end with programmable Manufacturing-as-a-Service capabilities that can withstand disruptions. A Digital Twin will provide a reliable model to represent production and operational data of an SMN to unlock deeper IMC intelligence. Collected data will train machine learning models to predict potential disruptions, such as natural disasters or delayed shipments. AI algorithms will analyse the data and provide real-time reporting and visualization on a dashboard. The IMC and Digital Twin interaction will generate powerful insights and self-adapting abilities that support an SMN to evolve under human supervision by switching services between multiple external partners to respond to risks and disruptions and improve energy efficiency, product circularity and environmental sustainability across the entire production process. The effectiveness of NARRATE will be evaluated by testing the IMC in real production environments in quite diverse industry sectors.