The ISIDORe consortium, made of the capacities of European ESFRI infrastructures and coordinated networks, proposes to assemble the largest and most diverse research and service providing instrument to study infectious diseases in Europe, from structural biology to clinical trials. Giving scientists access to the whole extent of our state of the art facilities, cutting edge services, advanced equipment and expertise, in an integrated way and with a common goal, will enable or accelerate the generation of new knowledge and intervention tools to ultimately help control SARS CoV 2 in particular, and epidemic prone pathogens in general, while avoiding fragmentation and duplication among European initiatives. Such a global and interdisciplinary approach is meant to allow the implementation of user projects that are larger, more ambitious and more impactful than the EU supported transnational activities that the consortium is used to run. Our proposition is ambitious but achievable in a timely fashion due to the relevance and previous experience of the partners that we have gathered and that have complementary fields of expertise, which addresses the need for an interdisciplinary effort. Leveraging all these existing strengths to develop synergies will create an additional value and enhance Europe capacity for controlling emerging or re emerging and epidemic infectious diseases, starting with the COVID 19 pandemic. Such a global and coordinated approach is consistent with the recommendations of the One Health concept and necessary to make significant contributions to solving complex societal problems like epidemics and pandemics.

Data and AI are the fuel of scientific discoveries, and Research Infrastructures (RIs) are at the forefront of this process, generating massive and increasingly more complex datasets. However, the growing size, diversity, and velocity of research data and software demand large-scale infrastructures and technical expertise from those on the user side. RI-SCALE will address this challenge by delivering Data Exploitation Platforms (DEPs). These scalable environments will co-host scientific data with preconfigured AI frameworks and models on powerful compute resources and unlock full data and AI potential for scientific users, RI operators and industry. RI-SCALE will design and develop the DEP technology with four RIs: ENES, EISCAT, BBMRI and Euro-BioImaging. DEP instances will be deployed for environmental and life sciences, validating the technology through 8 scientific and 4 technical use cases. These will run on national e-infrastructures from the EGI Federation and (pre)exascale machines from EuroHPC. RI-SCALE will collaborate with Destination Earth, EUCAIM cancer images data space, Copernicus Data Space Ecosystem, EOSC and Gaia-X to ensure interoperability within the broader landscape. The project will also facilitate industry and university collaborations, provide training and consultancy events to increase the uptake of AI technologies by additional RIs and explore sustainable DEP operation models for RI communities.

Euro-BioImaging ERIC is the ESFRI landmark to imaging excellence. It has completely changed the premises of European researchers by providing them with an open gateway to cutting-edge biological and biomedical imaging technologies, including access to expertise, data services, and training - all of which are essential ingredients for scientific breakthroughs and innovations to occur. Euro-BioImaging was established as an ERIC in December 2019 and since has grown quickly to currently 35 National Nodes representing 173 individual imaging facilities. 16 European countries and EMBL have committed to jointly operate this pan-European research infrastructure. The EVOLVE project, presented in this proposal, aims to significantly strengthen the young ERIC to reach its next level as a pan-European organization, and to live up to the needs and expectations expressed by its continuously expanding communities of users, partners, ERIC members, industry and other relevant stakeholders. Building on the EVOLVE project during the next 3,5 years, Euro-BioImaging will significantly strengthen its cost-efficient administration and set-up the next generation of its user access web portal. Furthermore it will foster the family of Euro-BioImaging Nodes and Hub at the personal, institutional, national and European level. The ERIC will implement a sustainable strategy for external relations with policy makers and funders, as well as boost its outreach and communication activities with new user communities for widening participation. An increased service offer, in particular for training (users and Nodes’ staff) and FAIR image data services will underpin excellence-driven user access and Open Science. Finally, EVOLVE will empower Euro-BioImaging facilities across Europe to underpin the Green and Digital Transition. With successful project conclusion Euro-BioImaging ERIC will have demonstrated the impact of this globally unique research infrastructure for European life sciences and beyond

canSERVs mission is to make cutting-edge and customised research services available to the cancer research community EU wide, enable innovative R&D projects and foster precision medicine for patients benefit across Europe. By connecting, coordinating, and aligning existing oncology and complimentary research infrastructures (RIs) and providing services in a synergistic way transnationally, canSERV will capitalise on the critical mass of experts and cutting-edge services offered by canSERVs RIs and their extended network. canSERV brings together world-class European life science RIs (BBMRI, EURO-BIOIMAGING, ELIXIR, EU-IBISBA, EuroPDX, EU-OPENSCREEN, INSTRUCT, EATRIS, INFRAFRONTIER, EMBRC, ECRIN, EATRIS, MIRRI, ARIE, CCE, EORTC and IARC) that collectively not only covers all aspects along the development pipeline for oncology, but is also capable of interconnecting these technologies providing users a guidance for navigating them through the entire translational value chain. A patient organisation or resp. governance board members wil bring the patients perspective, while the two SMEs, ARTTIC and ttopstart, will provide valuable input regarding stakeholder engagement, and project management activities. A common access management system (CAMS) will be developed based on mature solutions from INSTRUCT and BBMRI. The CAMS will provide a method for selection of services, construction and submission of research proposals, multi-step review of research proposals, and tracking of the access process from approval through delivery to conclusion. Through a united user-intuitive transnational access where a united catalogue of oncology services will be offered, our users will have access to a comprehensive service portfolio. As our ambition is to scale up canSERV to a pan-European collaboration of RIs for accelerating the development and implementation of solutions for the cancer patient community, the sustainability of this network beyond the end of the project will also be addressed.

ERIC – European Research Infrastructure Consortium – is a European legal instrument specifically created for European multi-side and multi-country owned Research Infrastructures (RI) in 2009. Since then 18 ERICs have been created in almost all different scientific domains. The European Commission (EC) had initiated an informal networking event, twice a year, where Managers of existing ERICs and scientists of future RI who want to use the ERIC instrument can discuss shared challenges and meet also national policy makers establishing a platform for exchange of solutions and best practises. With the H2020 call “INFRASUPP-01-2018-2019 Policy and international cooperation measures for research infrastructures” the EC is willing to fund a project for more formal and structural collaboration and coordination of ERICs. This project is set up by all existing ERICs and those consortia, which have at least submitted their Stage-1 application to implement the objectives of the call: • aim at strengthening coordination and networking reinforcing the informal ERIC network or its successor framework; • support the organisation of specific meetings, targeted thematic workshops focussing on shared challenges such as the development of internal procurement rules, harmonised reporting, VAT exemption practices, insurances and pensions policies and training of governance bodies representatives; • support ERICs in preparation, based on best practices; • support common communication and outreach activities and strengthening external representation of ERICs' as a stakeholder in consultations and other policy actions that could affect them.