SUPREME aims at optimizing powder metallurgy processes throughout the supply chain. It will focus on a combination of fast-growing industrial production routes and advanced ferrous and non-ferrous metals. By offering more integrated, flexible and sustainable processes for powders manufacturing and metallic parts fabrication, SUPREME enables the reduction of the raw material resources (minerals, metal powder, gas and water) losses while improving energy efficiency, production rate and CO2 emissions, into sustainable processes and towards a circular economy. To achieve this goal, an ambitious cross-sectorial integration and optimization has been designed between several powder metallurgy processes: gas and water atomization as well as ball milling for metal powder production, additive manufacturing and near-net shape technologies for end-parts fabrication. Quality and process control will be developed to monitor KPI, based on eco-innovation approach, to demonstrate the optimization of material and energy use. 4 demonstrators will be proposed at each step of the value chain in real industrial setting and ready for business exploitation at TRL 7: mineral concentration, metal powder manufacturing, metal part manufacturing and end-product that will validate a global optimization of more than 25% on material yield losses, more than 10% on energy efficiency, more than 10% on production rate and beyond 30% of CO2 emissions. SUPREME has gathered an outstanding consortium of 17 partners from 8 countries, represented by 11 companies including 6 SMEs that will ensure a successful implementation towards market applications. 5 applications sectors are targeted: automotive, aeronautics, cutting tools, molding tools and medical. The process key differentiation advantages will bring modularity, flexibility and sustainability to powder metallurgy and will reduce the total cost breakdown of these technologies, boosting their adoption by industry.

Microalgae are a source of secondary metabolites useful as new bioactive compounds. Activity of these compounds against bacterial pathogens and biofilm formation has not been determined yet. Biofilm formation is especially important in infections and tissue inflammation related to implants and catheters. These problems finally cause a release of the implant, which must be removed and replaced by a new one, entailing an increase in antibiotic consumption, together with a health costs of about 50,000-90,000 € per infection episode. Taking both problems in account, the search of new antimicrobial agents that will be effective against the bacteria in their two ways of life, planktonic and biofilm stage, is a priority need in the clinical practice. For this reason, the overall objective of NOMORFILM project is to search for antibiofilm compounds isolated from microalgae that will be useful in the treatment of this kind of infections and could be incorporated in the manufacturing of medical prosthetic devices. For this purpose, 4,000 microalgae species will be deeply screened specifically for new antibacterial and antibiofilm molecules. Structural elucidation of bioactive compounds from these extracts will assure that only new chemical entities, therefore with anticipated new mechanisms of action, will arise to further project stages, those including toxicity tests and animal models. This project also addresses the biosynthesis of the targeted bioactive compounds in sustainable microalgae co-cultures, diminishing cultivation costs by mimicking natural aquatic ecosystems. Most industrially interesting antibiofilm molecules will be incorporated into nanoparticles in order to develop manufacturing methodologies able to incorporate these compounds into real prosthetic devices matrixes. Marketing of results are assured by the presence of diverse SMEs along the manufacture and distribution of prosthetic devices, and the corresponding consortium agreements with respect to IPRs