The digital and circular economy (CE) transition of bio-based industries is a critical objective for Europe’s climate ambitions and its economic competitiveness. Given the urgency of these demands, Europe’s bio-based industries need to leapfrog over past digital technologies and implementations, pioneering innovative solutions for creating bio-based products and services that are circular, as well as environmentally and socially sustainable. To realise these ambitions, the bi0SpaCE project will deliver a suite of technologies, services, guidance frameworks, and standards, combined into the open-access bi0S platform, for rapid deployment and scaling of (CE) solutions and services across bio-based industries and their value chains. bi0SpaCE will advance the creation and implementation of Industry 4.0 enhanced Digital Product Passports (DPPs), linked to an International Dataspace (IDS) compliant CE dataspace, enabling the creation of dynamic and decentralised DPPs for secure and trustworthy sharing of CE and sustainability performance data of bio-based products across the value chain, as well as providing transparency of green and CE claims to consumers. bi0SpaCE brings together a consortium consisting of 1 HEI, 4 RTOs, 1 SMEs, 1 industrial assoc., 2 large industries, and 1 startup, across 5 EU and 2 associated countries, over a 36-month project period. The knowledge and technologies created in bi0SpaCE will be demonstrated and validated across 4 complementary bio-based sectors: (i) paperboard production, (ii) eco-industrial parks with bio-based energy and products producers and consumers, (iii) plant-based products and cosmetics, and (iv) bio-derived industrial chemicals.