The terahertz (THz) frequency region within the electromagnetic spectrum, covers a frequency range of about one hundred times that currently occupied by all radio, television, cellular radio, Wi-Fi, radar and other users and has proven and potential applications ranging from molecular spectroscopy through to communications, high resolution imaging (e.g. in the medical and pharmaceutical sectors) and security screening. Yet, the underpinning technology for the generation and detection of radiation in this spectral range remains severely limited, being based principally on Ti:sapphire (femtosecond) pulsed laser and photoconductive detector technology, the THz equivalent of the spark transmitter and coherer receiver for radio signals. The THz frequency range therefore does not benefit from the coherent techniques routinely used at microwave/optical frequencies. Our programme grant will address this. We have recently demonstrated optical communications technology-based techniques for the generation of high spectral purity continuous wave THz signals at UCL, together with state-of-the-art THz quantum cascade laser (QCL) technology at Cambridge/Leeds. We will bring together these internationally-leading researchers to create coherent systems across the entire THz spectrum. These will be exploited both for fundamental science (e.g. the study of nanostructured and mesoscopic electron systems) and for applications including short-range high-data-rate wireless communications, information processing, materials detection and high resolution imaging in three dimensions.

The smallest scale on which it is possible to design functional devices, including electronics, is the molecule scale (about 100,000 times smaller than the width of a human hair). This is the ultimate limit for miniaturisation and motivates research to manipulate and study the properties of individual molecules for applications in, e.g., information technologies and sensors. It is also the scale at which quantum phenomena dominate properties, so single-molecule structures offer a domain for investigations ranging from fundamental tests of quantum theory to developing components for future quantum technologies. To realise such experiments and technologies, it is necessary to incorporate individual molecules into electrical circuits. This is challenging because the typical size of a useful functional molecule is much smaller than the smallest wires that it is possible to fabricate, even with the most sophisticated lithography systems available today. Most researchers use one of two approaches. The first uses an electrical current or mechanical strain to make a tiny gap, a few nanometres across, in a thin wire, and then deposit the molecules of interest randomly, hoping that one and only one bridges the gap. This method relies on chance, and so it very rarely yields a working device: typically, only a very small proportion of devices fabricated show behaviour consistent with a single molecule in the gap and, because the shape of the gap and the orientation of the molecule are uncontrolled, it is rare for even such "working" devices to exhibit reproducible properties. The second method uses a scanning tunnelling microscope to locate and investigate molecules that are deposited on a conducting surface. This process is much more reliable and reproducible than the break junction method but it involves bulky experimental apparatus and it tightly limits the experimental geometry, ruling out the development of more complicated experiments or practical devices. These limitations in the existing methods have hamstrung the development of molecule-scale devices and technologies. Further progress in this field now requires the development of controlled and reliable methods that can be scaled to high volume production. This project will provide this methodology and demonstrate a range of prototype molecular devices. Our approach is based on DNA nanotechnology, which has, over the last decade, proved itself to be a powerful tool for controlled self-assembly of structures at the molecular scale. We will use these methods to direct the assembly of "packages" about 100 nanometres across. Constructed mainly from DNA with a precisely programmed structure, these packages will position gold nanoparticle contacts and the "target" molecular components, whose electrical transport properties we would like to exploit, with sub-nanometre accuracy. Our method produces trillions of packages at a time in a test-tube and ensures that each one has exactly the correct molecules incorporated in the correct positions and orientations between contacts. These gold nanoparticle contacts are large enough that we can connect them to laboratory equipment using standard nanolithography techniques. The technology has the potential for future development to connect multiple molecules in three-dimensional device architectures, and for the assembly of large-scale integrated molecular circuits. We propose to create several families of devices, designed to develop and prove this radically new molecular device fabrication methodology. These devices will give us an unprecedented experimental tool for probing electrical and magnetic properties of molecules, but they will also establish the potential for the industrial deployment of our technology. Central to the project are close interactions with industrial partners and knowledge transfer activities designed to accelerate commercial applications.

Development of technological advances is important in the continually growing nanotechnology market, which is set to exceed $125 billion within the next five years. 1-dimensional (1D) nanostructures, possessing one dimension outside the nanoscale (<100 nm) range, are typically nanowires, nanofibers and nanotubes, and occupy a significant portion of this fast-growing market due to their application in sectors ranging from batteries to biomedicine. Magnetic 1D materials have become particularly popular in recent years, as their large aspect ratio and 1D structure gives rise to anisotropy, which can produce orientated electronic and ionic transport and unusual anisotropic optical and magnetic properties. As a result of these properties, magnetic 1D materials have found application in magnetic recording, lithium ion batteries, sensors, catalysis and medicine. Such 1D materials can outperform their nanoparticle (or 0-dimensional, 0D) counterparts in many applications, for example in medicine, where anisotropy leads to increased magnetisation and local magnetic field strengths. This provides improved performance in medical imaging techniques such as magnetic resonance imaging (MRI), where 1D materials boost signal enhancement compared to their 0D analogues thanks to the increased anisotropy of their 1D structures. A number of new fabrication techniques for 1D materials have hence been pioneered and developed, including templating, bottom-up growth, lithography, electrospinning, and particle assembly, though these often suffer from poor tuneability of the resulting structures, and hence properties, as well as challenges with scalability - issues which are critical for their long-term use and industrial uptake. Magnetic interactions have long been used to generate colloidal structures which respond readily to a magnetic field, with ferrofluids being the most well-known example. The preparation of permanent 1D materials using magnetic assembly approaches has been explored recently, with clusters of magnetic nanoparticles being assembled into permanent arrays of nanowires or nanotubes either during synthesis, or through magnetically stimulated nanoparticle assembly. Although successfully forming 1D nanostructures, these approaches suffer from difficulties in controlling the resulting materials' size, aspect ratio and surface chemistry. There is, therefore, a clear need for a technique capable of reproducibly fabricating magnetic 1D nanostructures with controlled and tuneable aspect ratios, sizes and surfaces, at high scales. In this proposal, we aim to achieve this through the exploitation of continuous flow technology combined with magnetic assembly to produce core-shell 1D nanostructured materials with various coatings, which can be modified with ease for numerous different applications. This work will systematically explore the effect of flow rate, magnetic field strength and duration, magnetic nanoparticle building blocks and various coating agents in order to form a library of 1D materials whose properties are tuneable and reproducible. In this way, we will develop a novel, high throughput approach to magnetic 1D nanomaterials which will have precision control over structure, aspect ratio, surfaces and hence resulting properties of the 1D materials, in addition to the benefits of scalability that come with fluid flow systems. As a case study, the produced materials will be tested for their performance as contrast agents in magnetic resonance imaging (MRI). Using state-of-the-art magnetic resonance imaging tools, quantitative assessment of performance will demonstrate the benefits of tuneable 1D materials in this important medical application.

Dramatic progress has been made in the past few years in the field of photonic technologies, to complement those in electronic technologies which have enabled the vast advances in information processing capability. A plethora of new screen and projection display technologies have been developed, bringing higher resolution, lower power operation and enabling new ways of machine interaction. Advances in biophotonics have led to a large range of low cost products for personal healthcare. Advances in low cost communication technologies to rates now in excess of 10 Gb/s have caused transceiver unit price cost reductions from >$10,000 to less than $100 in a few years, and, in the last two years, large volume use of parallel photonics in computing has come about. Advances in polymers have made possible the formation of not just links but complete optical subsystems fully integrated within circuit boards, so that users can expect to commoditise bespoke photonics technology themselves without having to resort to specialist companies. These advances have set the scene for a major change in commercialisation activity where photonics and electronics will converge in a wide range of systems. Importantly, photonics will become a fundamental underpinning technology for a much greater range of users outside its conventional arena, who will in turn require those skilled in photonics to have a much greater degree of interdisciplinary training. In short, there is a need to educate and train researchers who have skills balanced across the fields of electronic and photonic hardware and software. The applicants are unaware of such capability currently.This Doctoral Training Centre (DTC) proposal therefore seeks to meet this important need, building upon the uniqueness of the Cambridge and UCL research activities that are already focussing on new types of displays based on polymer and holographic projection technology, the application of photonic communications to computing, personal information systems and indeed consumer products (via board-to-board, chip to chip and later on-chip interconnects), the increased use of photonics in industrial processing and manufacture, techniques for the low-cost roll-out of optical fibre to replace the copper network, the substitution of many conventional lighting products with photonic light sources and extensive application of photonics in medical diagnostics and personalised medicine. Many of these activities will increasingly rely on more advanced systems integration, and so the proposed DTC includes experts in computer systems and software. By drawing these complementary activities together, it is proposed to develop an advanced training programme to equip the next generation of very high calibre doctoral students with the required expertise, commercial and business skills and thus provide innovation opportunities for new systems in the future. It should be stressed that the DTC will provide a wide range of methods for learning for students, well beyond that conventionally available, so that they can gain the required skills. In addition to lectures and seminars, for example, there will be bespoke experimental coursework activities, reading clubs, roadmapping activities, secondments to collaborators and business planning courses.Photonics is likely to become much more embedded in other key sectors of the economy, so that the beneficiaries of the DTC are expected to include industries involved in printing, consumer electronics, computing, defence, energy, engineering, security, medicine and indeed systems companies providing information systems for example for financial, retail and medical industries. Such industries will be at the heart of the digital economy, energy, healthcare and nanotechnology fields. As a result, a key feature of the DTC will be a developed awareness in its cohorts of the breadth of opportunity available and a confidence that they can make impact therein.

A drug is a molecule that acts upon biological processes in the body. In contrast, a medicine is a complex product that comprises the drug and other ingredients packaged into a final dosage form that can be administered to a patient to ensure there is a beneficial therapeutic effect with minimum side-effects. To achieve therapeutic effect it is essential to ensure that the drug is delivered to the appropriate site in the body, at the right time, and in the correct amount. This is challenging: some drug molecules are poorly soluble in biological milieu, while others are either not stable or have toxic side-effects and require careful processing into medicines to ensure they remain biologically active and safe. The new drug molecules arising from drug discovery and biotechnology have particularly challenging properties. Pharmaceutical technologies are central to developing medicines from these molecules, to ensure patients are provided with safe and efficacious therapy. The design and development of new medicines is an inherently complex and cross-disciplinary process, and requires both innovative research and highly skilled, imaginative, researchers. To sustain and reinforce the UK's future global competitiveness, a new generation of highly-trained graduates educated at doctoral level is required to deliver transformative new therapeutics. Our CDT will train an empowered network of at least 60 PhD students through a consortium of multiple industry partners led by the University of Nottingham and University College London. The involvement of partners from start-ups to major international pharmaceutical companies will ensure that our students receive the cross-disciplinary scientific knowledge needed to develop future medicines, and build the leadership, resilience and entrepreneurial skills crucial to allow them to function effectively as future leaders and agents of change. Through partnering with industry we will ensure that the research work undertaken in the CDT is of direct relevance to contemporary and future challenges in medicines development. This will allow the CDT research to make significant contributions to the development of new therapies, leading ultimately to transformative medicines to treat patients. Beyond the research undertaken in the CDT, our graduates will build careers across the pharmaceutical and healthcare sector, and will in the future impact society through developing new medicines to improve the health and well-being of individuals across the world. We will train our students in four key science themes: (i) predictive pharmaceutical sciences; (ii) advanced product design; (iii) pharmaceutical process engineering; and, (iv) complex product characterisation. This will ensure our graduates are educated to approach challenges in preparing medicines from a range of therapeutic molecules, including emerging cutting-edge actives (e.g. CRISPR, or locked RNAs). These are currently at a critical stage of development, where research by scientists trained to doctoral level in the latest predictive and product design and development technologies is crucial to realise their clinical potential. Our students will obtain comprehensive training in all aspects of medicines design and development, including pharmaceutical engineering, which will ensure that they consider early the 'end game' of their research and understand how their work in the laboratory can be translated into products which can be manufactured and enter the clinic to treat patients.