A major part of the diagnosis of any disease but particularly various forms of cancer, is obtained though a biopsy. This involves removing a small sample of tissue, or a few cells, from the patient. These samples, either tissue or cells are then examined by a pathologist looking down an optical microscope. In most cases the sample is stained with a combination of dyes to help gain some contrast. In most cases, based upon visual inspection of the sample a diagnosis is made. This process if far from ideal since it relies on the expertise of the clinician concerned as is subject to intra in inter observer error. Recently a number of proof of concept studies have shown that molecular spectroscopic techniques such as infrared and Raman are capable of distinguishing diseased from non diseased cells and tissue based upon the inherent chemistry contained within the cells. The UK is at the forefront of these developments but there are many hurdles that need to be overcome if this technology is to move from the proof of concept stage through the translational stage and into the clinical setting. It is the belief of the academic community that we are much more likely to overcome these hurdles if we pool our resources, bring in both industrial and clinical partners and work on these generic problems together. This application is for funding to support such a network of partners for the next three years.

The ability to look at small numbers of molecules in a sea of others has appealed to scientists for years. On the fundamental side we want to watch in real time how molecules undergo chemical reactions directly, how they explore the different ways they can come together, interact and eventually form a bond, and ideally we would like to influence this so that we can select just a single product of interest. We also want to understand how molecules react at surfaces since this forms the basis of catalysis in industrially relevant processes and is thus at the heart of almost every product in our lives. However, most scientific studies take place in precise conditions achieved in the laboratory, such as high vacuum, to select the cleanest possible conditions, but which look nothing like the real world applications they simulate. Hence most knowledge is empirical and pragmatically optimised. We have been working on a completely new way to watch chemistry in an incredibly tiny test tube, itself a molecule. We use a barrel-shaped molecule called a 'CB' that can selectively suck in all sorts of different molecules. Recently, we have found a way to combine these barrel containers with tiny chunks of gold a few hundred atoms across, in such a way that shining light onto this gold-barrel mixture focuses and enhances the light waves into tiny volumes of space exactly where the molecules are located. By looking at the colours of the scattered light, we can work out what molecules are present and what they are doing, with enough sensitivity to resolve tiny numbers. Our aim in this grant is to explore our promising start (that was seeded by EU funding). We aim to develop all sorts of ways to make useful structures that sense neurotransmitters from the brain, protein incompatibilities between mother and foetus, watch hydrogenation of molecules take place, find trace gases that are dangerous, and many others. At the same time we want to understand much more deeply and carefully how we can go further with such ideas, from controlling chemical reactions happening inside the container, to making captured molecules inside flex which can result in colour-changing switches. To make all this happen we take research groups spanning physics and chemistry and completely mix them up, so that they can work together on these very interdisciplinary aspects. We have found this works extremely well. We also involve a number of companies and potential end users (including the NHS) who know the real problems when trying to exploit these technologies in important areas including diagnostics, imaging and catalysis.

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

In a consortium led by Heriot-Watt with St Andrews, Glasgow, Strathclyde and Dundee, this proposal is for an EPSRC CDT in Applied Photonics and responds to the Integrative Technologies priority area, but also impacts on the Measurement and Sensing, Photonic Materials and Innovative Production Processes priorities. Technologies integrating photonics and electronics pervade products and services in any modern economy, enabling vital activities in manufacturing, security, telecommunications, healthcare, retail, entertainment and transport. The success of UK companies in this technology space is threatened by a lack of doctoral-level researchers with a grasp of photonic- / electronic-engineering design, fabrication and systems integration, coupled with high-level business, management and communication skills. By ensuring a supply of these individuals, our CDT will deliver broad-ranging impacts on the UK industrial knowledge base, driving the high-growth export-led sectors of the UK economy whose photonics-enabled products and services have far-reaching impacts on society, from consumer technology and mobile computing devices to healthcare and security. Building on the success of our current IDC in Optics and Photonics Technologies, the proposed CDT will again be configured as an IDC but will enhance our existing programme to meet industry's need for engineers able to integrate photonic and electronic devices, circuits and systems to deliver high value products and processes. Our proposal was developed in partnership with industry, whose letters of support show a commitment to sponsoring 71-74 EngD and 14-17 PhD projects -- 40% more than the minimum required -- demonstrating exceptional industrial engagement. Major stakeholders include Fraunhofer UK, NPL, Renishaw, Thales, BAE Systems, Gooch and Housego and Selex ES, who are joined by a number of SMEs. The CDT follows a model in which (annually) EPSRC funds 7 EngD students, with 3 more supported by industrial / university contributions. In a progressive strategy supported by our industrial partners, we will, where appropriate, align university-funded PhD projects to the programme to leverage greater industry engagement with PhD research in the consortium. The focus of the CDT corresponds to areas of research excellence in the consortium, which comprises 89 academic supervisors, whose papers since 2008 total 584 in all optics journals , with 111 in Science / Nature / PRL, and whose active EPSRC PI photonics funding is £40.9M. All academics are experienced supervisors, having each supervised on average >6 doctoral students, with many previously acting as IDC supervisors. The strategic commitment by the participating universities is evidenced by their recruitment since 2008 of 29 new academic staff in relevant areas (including 9 professors). An 8-month frontloaded residential phase in St Andrews and Glasgow will ensure the cohort strongly gels together, and will equip students with the technical knowledge and skills they need before they begin their industrial research project. Business modules (x3) will bring each cohort back to Heriot-Watt for 1-week periods, and weekend skills workshops will be used to regularly reunite the cohort, further consolidating it to create opportunities for peer-to-peer interactions. Taught courses will total 120 credits, and will be supplemented by new Computational Methods, Systems Integration and Research Skills workshops delivered by our industry partners, as well as public-engagement training led by Glasgow Science Centre. Another innovation is an International Advisory Board, comprising leading academics / industrialists , who will benchmark and advise on our performance. The requested EPSRC support of £4.5M is complemented by £2.8M of industrial / academic cash, covering the cost of 3 students in each cohort of 10. In-kind industrial / academic contributions are worth a further £5.4M, providing exceptional value.

We propose a Centre for Doctoral Training in Integrative Sensing and Measurement that addresses the unmet UK need for specialist training in innovative sensing and measurement systems identified by EPSRC priorities the TSB and EPOSS . The proposed CDT will benefit from the strategic, targeted investment of >£20M by the partners in enhancing sensing and measurement research capability and by alignment with the complementary, industry-focused Innovation Centre in Sensor and Imaging Systems (CENSIS). This investment provides both the breadth and depth required to provide high quality cohort-based training in sensing across the sciences, medicine and engineering and into the myriad of sensing applications, whilst ensuring PhD supervision by well-resourced internationally leading academics with a passion for sensor science and technology. The synergistic partnership of GU and UoE with their active sensors-related research collaborations with over 160 companies provides a unique research excellence and capability to provide a dynamic and innovative research programme in sensing and measurement to fuel the development pipeline from initial concept to industrial exploitation.