"Building bridges between the worlds of education and business is a priority for Europe. While teachers are not sufficiently ""equipped"" regarding their knowledge of the economic, financial and organizational issues that structure companies and their role in economic development, these actors often have a biased representation of the school institution and its operation.The objective of Cokleeco is to promote a better mutual understanding between these two spheres, to update their mutual representation and to develop cooperation through the development of a training program corresponding to the realities of different organizations in the territories of project partners.9 partners, from 5 countries, from both the world of education and the company were involved in this project:Freref, a European network active on the issues of lifelong learning, based in France, managed it.In Auvergne-Rhône-Alpes (France), the project was carried by the regional MEDEF and the rectorate of the academy of Grenoble.In Emilia-Romagna (Italy), the project involved the Regional Confindustria and the University of Modena-Reggio (Unimore).In French-speaking Belgium, the Foundation for Education (FPE) for the promotion of the school-companies relationship as well as the General Directorate of Compulsory Education (DGEO) of the Wallonia-Brussels Federation contributed with their respective expertise.In Catalonia (Spain), the education department of the Regional Government of Catalonia participated in the project.Finally, in Poland, the MCDN, a continuing training center for teachers in the province of Malopolska (Krakow) gave their inputs on the question of the school-enterprise relationship.The Cokleeco project was dedicated to 3 categories of target audience.-The world of education with teachers, but also the actors of guidance and school heads;-The economic world with entrepreneurs, HR managers, business tutors ...;- young people in school (high school students, middle school students, apprentices, students ...).As a first step, the project collected innovative practices existing in the territories. These practices were then clustered with the aim of constructing a prototype of a training pathway using a decontextualization / recontextualization approach.On the basis of this prototype, the partners have developed pathways for each of their territory, in order to meet the expectations of local stakeholders. These courses were tested locally and during a week of mobility in Italy, the participants were able to share the comments and suggestions obtained in order to build a European training pathway. This pathway, common to the ""business"" and ""education"" people was then tested during a second mobility that took place in Grenoble (France) during which about thirty European participants from the world of education and companies were able to deconstruct their a-priori during exchange sessions and a day of immersion. The participants were then accompanied to build new actions, in a transnational way so that this better knowledge of the respective environments will benefit the final target audience: the students.This step was carried out during pilot actions involving the different target groups of the project, which made it possible to obtain the opinion of external participants and different audiences.Project partners have formulated lessons learned and recommendations so that they can share their experience with new actors wishing to become involved in this process.The impacts obtained by the Cokleeco project are numerous:In Spain, Italy and France the partners involved in the project are planning to renew the European training course on their territory with for example a ""teacher summer camp"" initiated in Italy in September 2019, which should take place in 2020.In Poland, some training content has been incorporated into MCDN teacher training.In Catalonia, the project was presented within the entrepreneurship network of the Ministry of Education of Catalonia with the aim of implementing the training pathway for VET teachers.In Belgium, the results of the project have been integrated in the reflections around the realization of the Pact4Youth currently led by the government of the Federation Wallonia Brussels.In Auvergne-Rhône-Alpes, the project has made it possible to identify previously isolated practices and to recruit new players for future initiatives.At least 5 new European projects have sprouted through the Cokleeco project, one of these being already funded by the Italian Erasmus+ agency."

Big data applications processing extreme amounts of complex data are nowadays being integrated with even more challenging requirements such as the need of continuously processing vast amount of information in real-time. Current data analytics systems are usually designed following two conflicting priorities to provide (i) a quick and reactive response (referred to as data-in-motion analysis), possibly in real-time based on continuous data flows; or (ii) a thorough and more computationally intensive feedback (referred to as data-at-rest analysis), which typically implies aggregating more information into larger models. Given the apparently incompatible requirements, these approaches have been tackled separately although they provide complementary capabilities. CLASS aims to develop a novel software architecture to help big data developers to combine data-in-motion and data-at-rest analysis by efficiently distributing data and process mining along the compute continuum (from edge to cloud) in a complete and transparent way, while providing sound real-time guarantees. CLASS aims at adopting (1) innovative distributed architectures from the high-performance domain; (2) timing analysis methods and energy-efficient parallel architectures from the embedded domain; and (3) data analytics platforms and programming models from the big-data domain. The capabilities of the CLASS framework will be demonstrated on a real smart-city use case, featuring a heavy sensor infrastructure to collect real-time data across a wide urban area, and prototype cars equipped with heterogeneous sensors/actuators, V2I connectivity, and cluster support to present the innovative capabilities to drivers. Representative applications for traffic management and advanced driving assistance domains have been selected to efficiently process very large heterogeneous data streams in real-time, providing innovative services while preparing the technological background for the advent of autonomous vehicles

The possibility to artificially induce and expand in vitro tissue-specific stem cells (SCs) is an important goal for regenerative medicine, to understand organ physiology, for in vitro modeling of human diseases and many other applications. Here we found that this goal can be achieved in the culture dish by transiently inducing expression of YAP or TAZ - nuclear effectors of the Hippo and biomechanical pathways - into primary/terminally differentiated cells of distinct tissue origins. Moreover, YAP/TAZ are essential endogenous factors that preserve ex-vivo naturally arising SCs of distinct tissues. In this grant, we aim to gain insights into YAP/TAZ molecular networks (upstream regulators and downstream targets) involved in somatic SC reprogramming and SC identity. Our studies will entail the identification of the genetic networks and epigenetic changes controlled by YAP/TAZ during cell de-differentiation and the re-acquisition of SC-traits in distinct cell types. We will also investigate upstream inputs establishing YAP/TAZ activity, with particular emphasis on biomechanical and cytoskeletal cues that represent overarching regulators of YAP/TAZ in tissues. For many tumors, it appears that acquisition of an immature, stem-like state is a prerequisite for tumor progression and an early step in oncogene-mediated transformation. YAP/TAZ activation is widespread in human tumors. However, a connection between YAP/TAZ and oncogene-induced cell plasticity has never been investigated. We will also pursue some intriguing preliminary results and investigate how oncogenes and chromatin remodelers may link to cell mechanics, and the plasticity of the differentiated and SC states by controlling YAP/TAZ. In sum, this research should advance our understanding of the cellular and molecular basis underpinning organ growth, tissue regeneration and tumor initiation.