Despite a constant increase in plastic worldwide production, the environmental risk linked to microplastics remains little studied today. The PLASTERA project aims to define this risk in a global pollution context in the Loire River and its estuary, while considering environmental, animal and human health. This project will be divided into four phases: i) to characterize the plastic exposome in the Loire River and its estuary, ii) the use of an active biomonitoring approach to assess its effects on various sentinel species, iii) to characterize the effects of these environmental contaminants from bivalves to humans at sub-individual levels and iv) to provide data to help regulation of this emerging contamination while raising citizen awareness of this contamination. This project aims to be in line with the "One Health" concept considering environmental health (determination of contamination and its effects at the level of four habitats: freshwater / marine water / benthic / endobenthic), animal and human health (in situ exposures of sentinel species in these habitats and in vitro exposures of animal and human immune cells). The new IBR-T index (integrative biomarker responses) will be deployed to summarize the effects of this contamination and raise awareness of the general public, communities and other stakeholders.

Industry 4.0 suggests a reactive and flexible management of production lines as well as the advent of new decision support tools based on the use of data collected in real time. However, there is still a need for implementation and integration into traditional production management approaches in the broad sense. Our project seeks to answer these questions for the improvement of the articulation of tactical and operational decisions, based on new concepts of predictive and prescriptive maintenance. This will lead to new integrated approaches to planning, scheduling and maintenance, taking into account different levels of uncertainty, accompanied by new performance-oriented indicators for the robustness of production plans. In addition, this project will serve to define a set of specifications related to the data to be collected as well as associated management rules which will then form the "skeleton" of a digital shadow developed throughout the project and motivated by an industrial application in the medical device sector.

The BB EEG platform project aims at developing an Internet portal providing telemedicine and e-learning services in the field of the electroencephalographic (EEG) signals of the newborn. The EEG consists in recording the spontaneous electrical activity of the brain through several electrodes placed on the scalp. It is a functional review that provides additional results to brain imaging data (MRI tomdensitometry). The neonatal period is a high risk neurological damage period because of the immature nature of the brain for the premature births and/or because of non optimal conditions at birth (anoxia, infection .). The consequences can be severe and cause permanent and severe disabilities. The EEG enables the assessment of the brain function. It monitors the brain maturation during the first weeks of life if the child is born premature. The EEG makes possible the evaluation of the degree of brain damage in cases of difficult birth (e.g. cerebral anoxia). It can also detect possible seizures and monitor their evolution under treatment. In this case we must couple the EEG with a synchronized video of the patient in order to properly identify abnormal clinical manifestations. The techniques of neuroprotection starting to be commonly used, as for example the controlled hypothermia for cases of cerebral anoxia, require that an accurate assessment of the severity of brain damage be done. The EEG allows the physiological assessment but requires trained personnel for both the acquisition of EEG signals and their interpretation. The neonatal EEG requires highly specialized personnel. The French expertise is recognized but its daily practice suffers from a growing shortage of specialists. The Video EEG signals are recorded in digital form by a technician and visually analyzed by a doctor after their acquisition. They can also be analyzed by tools of signal processing in order to complement, accelerate or intensify the visual analysis.These characteristics prove that the EEG signals will fit well to telemedicine activities. Thus some members of the consortium have developed in Loire Valley for several years a EEG signals transport mean between hospitals Laval and Le Mans. In Bourgogne there is also an telemedicine activity around the EEG. In the Pays de la Loire region there are adapted facilities that enable the transmission of large amount of data. However, technical constraints (transport of medical data) and organizational (type of economic exploitation, work organization conditions for different personal ....) are hampering the application of EEG telemedicine activities on an industrial scale. Moreover, it is very important to ensure that the development of remote interpretation is not accompanied by a loss of competence. The BB EEG project will thus pave the way for the industrial development of the telemedicine activities and will contribute to maintaining the recognized excellence of the French school in this area. Our consortium brings together all the players necessary to tackle these barriers. It combines several hospitals in the region of Pays de la Loire with industry specializing in the secure transport of medical data, the work flow organization and its potential applications for learning strategies, with researchers in mathematics and signal processing fields. The hard goal of the BBEEG project is to provide a portal offering a combination of different services for a much rapid and secure diagnostic and for the newborn EEG training. The target audience are hospitals that do not have the competence of physicians who request a second opinion and professionals (doctors and technicians EEG) who wish to gain competence in this area. Our project will constitute a methodological framework for other initiatives in other medical fields.

The methodological approach of the AuFic project, while comprehensive, remains resolutely focused on the actual lived experience of autistic people. It aims to study gendered representations of autism in fiction and the way autistic people interpret and renegotiate them. Knowledge about autism has always been highly controversial in France, where autistic people and their allies are still fighting for recognition and support adapted to their distinctive challenges. It is therefore vital to study how autistic people are represented in cultural productions and in the media. We hypothesise that the tropes that fictions have tended to draw on are restrictive, be they that of an autistic person as intellectually deficient, or, more recently, as a reclusive male genius (Chamak, 2015). But we also expect an emergent diversification of models of characters with autism as a result of transnational attempts to raise awareness about women with autism and autistic people concerned by gender and sexual diversity. Our goal is thus to study these transformations of the representations of autism, the way autistic people perceive them, and if and how autistic people take it upon themselves to produce alternative representations. For this purpose, the AuFic project is essentially based on a sociohistorical analysis of representations in the media, an ethnographic approach, and a creative research, applied to three fieldwork projects: a constitution and analysis of a corpus of fictions with autistic characters since the 1980s; qualitative interviews with autistic people about their relation with fiction and their eventual writing practices; and the creation of a podcast and animated short films developing a variety of representations of autism.