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University of Manchester

University of Manchester

760 Projects, page 1 of 152
  • Funder: European Commission Project Code: 332393
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  • Funder: European Commission Project Code: 871075
    Overall Budget: 5,000,000 EURFunder Contribution: 5,000,000 EUR

    The diversity, complexity and volume, as well as privacy and regulatory considerations, necessitate a collaborative and federated approach to life-science data. For scientists to find and share data across Europe and world-wide, ELIXIR needs to continuously develop and connect its services. The international ecosystem provided by ELIXIR – with 220 institutes in 23 Nodes, connecting hundreds of bioinformatics services – is globally unique and a competitive advantage for European research. Through our national Nodes ELIXIR has the geographical spread, service portfolio and expertise to fulfil our ambition that every European project uses FAIR data based on common standards, tools and services. The initial operational phase of ELIXIR, supported by the H2020 ELIXIR-EXCELERATE project, focussed on the coordination and delivery of bioinformatics services from national Nodes. This lay the foundation for a coordinated European infrastructure. ELIXIR-CONVERGE will build on these achievements to deliver another critical component: the provisioning, across Europe, of distributed local support for data management based on a toolkit for researchers that enables lifecycle management for their research data according to international standards. ELIXIR-CONVERGE will develop the national operations of such a distributed research infrastructure to drive good data management, reproducibility and reuse in a heterogeneous funding landscape. Over 36 months and with partners from our 23 Nodes, ELIXIR-CONVERGE takes the next step to realise a European data federation where interconnected national operations, strategically managed via national research infrastructure roadmaps, allow users to extract knowledge from life science’s large, diverse and distributed datasets. By connecting ELIXIR Nodes to provide FAIR data management as a service, ELIXIR-CONVERGE will build national capacity and create a blueprint for operating sustainable Nodes in distributed research infrastructures.

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  • Funder: European Commission Project Code: 812991
    Overall Budget: 4,167,590 EURFunder Contribution: 4,167,590 EUR

    The explosive growth of applications and industrial sectors that rely on broadband connectivity, is set to stretch the demand for wireless networks beyond the reach of the power grid infrastructure. Access points are being deployed on board of drones, while more than 84,000 hybrid-energy base stations are expected to be deployed annually in remote areas by 2020. Portable network nodes that are energy-autonomous and operate detached from the power grid will become indispensable in the coming applications of wireless networks. Energy-autonomy presents immense challenges for the wireless network design and imposes a complete re-think of technological solutions. PAINLESS has the visionary aim to establish a training and research platform to pioneer green, energy-autonomous portable network nodes which are self-subsistent and limitlessly-scalable, to satisfy future demands with minimal infrastructure. It promises a paradigm shift by integrating and jointly optimising wireless networks with renewable energy sources, radiated energy harvesting and airborne access points, as well as establishing disruptive performance benchmarks for the combined wireless power-and-information distribution. Our results will kick-start an innovation ecosystem for infrastructure and service providers of ICT to develop and commercialise a new generation of autonomous, sustainable and power-independent communication networks with self-organising functionality, to enable 100% coverage in urban environments in a power-efficient manner; provide network access to all types of emergency, disaster and special events areas; and connect remote / developing areas with problematic infrastructure. PAINLESS relates to H2020-MSCA with a vision to produce the first generation of experts in a radically new wave of energy autonomous networks that will revolutionise the wireless networking technology landscape and the plethora of associated vertical business sectors.

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  • Funder: European Commission Project Code: 695013
    Overall Budget: 2,494,330 EURFunder Contribution: 2,494,330 EUR

    Our group has recently discovered a new type of cofactor: a prenylated-flavin that has azomethine ylide properties. This cofactor is an integral part of the widespread ubiD/ubiX system. The latter is implicated in the non-oxidative reversible decarboxylation of aromatic substrates, and plays a pivotal role in bacterial ubiquinone biosynthesis or microbial biodegradation of aromatic compounds. We established UbiX acts as a novel flavin prenyltransferase, linking a dimethylallyl moiety to the flavin N5 and C6 atoms. Formation of the holo-UbiD enzyme involves oxidative maturation of the new cofactor, creating the novel azomethine ylide moiety. The dipolarophile substrate binds directly above the azomethine ylide group, and our data strongly suggests 1,3-dipolar cycloaddition chemistry supports reversible decarboxylation in these enzymes. While 1,3-dipolar cycloaddition is commonly used in organic chemistry, this presents the first example of an enzymatic 1,3-dipolar cycloaddition reaction. Our model for UbiD catalysis hints at new routes in alkene hydrocarbon production or aryl (de)carboxylation. The current application builds ambitiously on these results and takes the project altogether to another level: we seek to investigate structure/function of relationships of the wider UbiD family, ultimately including the multi-subunit enzymes that couple ATP-hydrolysis to benzene or naphthalene carboxylation. Furthermore, we will explore and harness the unusual properties of the prenylated flavin, through targeted evolution of (monoxygenase) flavoenzymes to create artificial prFMN-dependent self-sufficient monoxygenases. Our approach seeks to harness both the UbiD and the artificial prFMN-dependent enzymes in novel green routes to commodity chemicals.

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  • Funder: European Commission Project Code: 881603
    Overall Budget: 150,000,000 EURFunder Contribution: 150,000,000 EUR

    This proposal describes the third core project of the Graphene Flagship. It forms the fourth phase of the FET flagship and is characterized by a continued transition towards higher technology readiness levels, without jeopardizing our strong commitment to fundamental research. Compared to the second core project, this phase includes a substantial increase in the market-motivated technological spearhead projects, which account for about 30% of the overall budget. The broader fundamental and applied research themes are pursued by 15 work packages and supported by four work packages on innovation, industrialization, dissemination and management. The consortium that is involved in this project includes over 150 academic and industrial partners in over 20 European countries.

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