The RRI-Practice project will bring together a unique group of international experts in RRI to understand the barriers and drivers to the successful implementation of RRI both in European and global contexts; to promote reflection on organisational structures and cultures of research conducting and research funding organisations; and to identify and support best practices to facilitate the uptake of RRI in organisations and research programmes. The project will review RRI related work in 22 research conducting and research funding organisations and will develop RRI Outlooks outlining RRI objectives, targets and indicators for each organisation. It will involve comparative analysis of the five EC keys of RRI locating these within broader, evolving discourses on RRI. Within each identified RRI dimension the project will analyse how the topic has developed in particular social and institutional contexts, how the RRI concept and configuration meshes, overlaps and challenges existing organisational practices and cultures, leading to an analysis of the barriers and drivers associated with operationalising and implementing RRI. 12 national case studies will allow for in depth studies of, and dialogue with, the included organisations, and will form the basis for systematic analysis and comparison of drivers, barriers and best practices on each dimension of RRI. The project design also allows analysis of such drivers, barriers and best practices related to national and organisational characteristics, safeguarding the need to take into account diversity and pluralism in regional RRI programs. These analyses will ultimately end up in recommendations to the EC about effective, efficient and targeted strategies for increasing RRI uptake in different kinds of organisations and national cultures, in Europe and in selected major S&T intensive economies worldwide. The project will also develop user-friendly guidance aimed directly at research and funding organisations themselves.

Despite advances in the medical management of high-risk pregnancies and deliveries, cerebral palsy (CP) remains the most common physical disability in childhood in high and low-to-middle income (LMIC). In addition, caregivers of children with CP are at higher risk of psychiatric issues, further increasing health and socio-economic burden to the families. In spite of the scientific advancements in early detection and intervention (EI) in CP, there is a lack of implementation into clinical service delivery. The overarching aim of the BORNTOGETTHERE program is to exploit current evidence on early detection and efficacy of EI for infants at high risk of CP by implementing the International Clinical Practice Guideline in Europe (Italy, Denmark, Netherlands), LMIC (Georgia, Sri Lanka) and hard to reach populations (Remote Queensland and Western Australia). It will provide a multifaceted knowledge translation approach focused on i) optimizing context-specific health programs for early detection of CP, thus reducing age at diagnosis and age at referral to EI; ii) optimizing early functional characterization of infants with CP, thereby fostering personalized EI and preventing secondary complications (i.e. hip dislocation) and iii) testing the implementation of integrated EI programs adapted to country-specific welfare systems. The protocol of service delivery will result from the adaptation of early detection and EI programs based on the proven, effective intervention strategies, and those that are included into ongoing research based on effectiveness shown with preliminary data. This framework will be validated in real life varying world conditions through a large implementation program and a multicentre parallel controlled trial. The main beneficiaries will include a wide range of stakeholders: not only concerned families and communities but also policy makers, public authorities, the media, and citizen groups to ensure the translation of evidence into routine practice.