The new European Commission launched the European Green Deal last autumn as one of its key policies. Among the various strategies, Biodiversity 2030 and Farm to Fork are of tremendous importance for France that has placed sustainability of its agri-food system as one of its priorities. For the past two years, INRAE has brought together the European research community around the vision of an agriculture free of chemical pesticides. This community of now 34 members from 20 European countries joined forces to create the European Research Alliance “Towards a Chemical Pesticide-free Agriculture” (hereafter referred to as “the Alliance”). Through regular exchanges with European Commission services, the Alliance highlighted the need to address this issue that appeared as a target both in the Biodiversity 2030 and Farm to Fork strategies. In order to support the ambition and to strengthen the position of France in this domain, INRAE decided to lead the proposal from the Alliance “” on the call LC-GD-6-1-2020 Topic title: Testing and demonstrating systemic innovations in support of the Farm-to-Fork Strategy, scope C. This project will strongly rely on the implication of actors all across Europe with almost 75% of the members states covered in this project. It will be first based on the identification of pluri-disciplinary innovative solutions, technical (e.g. precision agriculture, robotics…) agronomic (e.g. agroecology, rotation, diversification…), biological (e.g. genetics/varieties, biocontrol, biostimulants…) but also socio-economic (e.g. governance, supply chain organization, willingness to pay by consumers, regulatory …), and their optimization to foster potential synergies. It will then strongly rely on demonstrating the relevance and feasibility of these solutions, i.e. documenting their actual impact on the reduction of pesticides and fertiliser uses, with common metrics such as the methodology created in the French CEPP design (certificats d'économie de produits phytopharmaceutiques), as well as on the monitoring of their impact in real-life situation thanks to the dense network of experimental facilities from the Alliance members as well as their connections with other national or European farm networks. Companies providing new options (varieties with better disease resistance and fertiliser use efficiency, biocontrol, digitalisation, machineries) will be included into the consortium. The precise assessment of the economic impact and the analysis of the barriers limiting the implementation of these solutions and the strong dissemination targeted to relevant actors will allow empowerment of the actors and scaling up alternative protecting methods that will reduce pesticide use. Regular exchanges with local, national and European decision makers will allow supporting the implementation of the identified technical or socio-economic solutions. Ultimately this global approach will give access to new potential solutions adapted to local conditions that could undergo the same optimization, testing, dissemination steps. This approach was built using the backward construction of impact pathways. This ex-ante methodology will be further developed in order to maximize the impact potential of the project. Furthermore, to allow dynamic evolution of the project throughout its life, a real-time analysis of the impact will be conducted (in-itinere) using the recognized ASIRPArt methodology.