Neurodevelopmental disorders (NDDs) affect 3-8 percent of children across Europe and cause a life-long alteration of cognitive abilities or social interactions with little therapeutic possibilities. Recent studies have uncovered that dysfunctional mitochondria and metabolism are involved in NDDs like intellectual disability and autism spectrum disorder. Notably, neuronal circuit development, a crucial process during the formation of the brain, is characterized by an increase in metabolic activity supporting a period of intense remodelling. However, the knowledge of molecular processes controlling metabolic homeostasis during neural circuit development is still incomplete. We recently defined the autism-associated kinase NUAK1 as a critical regulator of local mitochondrial metabolism in neurons, supporting axon morphogenesis. However it is not clear how NUAK1 controls metabolic processes in neurons. We have identified a novel substrate of NUAK1 and hypothesize that NUAK1 controls an alternative splicing program through this new interactor, thereby regulating metabolism, which in turn affects neuronal development. We will: 1. Perform a phenotypical characterization of the novel substrate’s role in developing neurons in vitro and in vivo; 2. Investigate its effect on neuronal and axonal metabolism; 3. Characterize its associated transcriptomic signature in developing neurons; and 4. Assess the role of NUAK1 in controlling its novel substrate functionally. For this, we will use state-of-the-art techniques like microfluidic devices and deep-sequencing of mRNA. This ambitious project aspires to describe a new cellular pathway, integrating RNA biology and metabolism in developing neurons and will provide the first characterization of a novel interactor of NUAK1 and its control by the latter in developing neurons.

Trust plays a very important role in economic and social interactions. It reduces transaction costs, promotes efficiency in markets, improves cooperation, and increases the ability of people, organizations and countries to adapt to complexity and change. Trust is also very fragile and can be easily break with extremely detrimental consequences for society. This highly interdisciplinary research project aims to develop a pioneer analysis of what is considered one of the most fundamental threats of trust, and, a major concern of modern society: dishonesty. The central objective of “IDEA” is to provide a better understanding of the determinants of dishonest behaviour by incorporates psychological, emotional and social factors that have been only recently brought into economics. Within this framework, “IDEA” intends to develop and test new mechanisms to fight against dishonesty which entail a lower cost for society, and preserve the freedom of citizen. More specifically, “IDEA” will investigate what individual characteristics are more/less likely to be associated with dishonest behaviour to provide a better understanding of deceptive behaviour, and obtain an identikit of a dishonest individual. It will examine the nexus between dishonesty and competition, in order to determine why competitive pressures induce more cheating, and which features of the competitive environment are linked to more dishonesty. By exploring the deterrence effect of information disclosure on audits and sanctions, “IDEA” will help to develop an optimal system of sanctions which discourage dishonesty, and minimize the monetary costs of the enforcement authority and the psychological costs of the citizens.

The Martian missions have gradually revealed that Mars abounds with evidence of a full ancient hydrological system favourable to life emergence. If so, there is every reasons to believe that Mars has hosted a hemispheric ocean covering the northern lowlands. This hypothesis is as old as Mars exploration, but has been repeatedly challenged over the past two decades. The case of primitive Martian ocean remains one of the planet’s most controversial and unsolved issue. Recent discoveries are re-opening this question mainly highlighting that the main oceanic activity may be older than we thought with related deposits partly exhumed and two rovers (Mars2020/NASA arrived in 2021 and ExoMars/ESA-Roskosmos to be launched in 2022) have landing sites in the oldest terrains never explored on Mars, displaying sediments possibly linked with an ocean system. To wind up the debate, the identification of ancient deposits of the same age, same composition with a global distribution in agreement with a possible ocean level is required. But such clues are small scale exposures solved only by high-resolution orbital data set (>10 To of data) or by in situ exploration preventing a forward link to the global context. Oceanid proposes to face this challenge by investigating at different scale: global, mesoscale and microscale using complementary dataset (orbital, in situ and experimental data). Oceanid will also lie on innovative methodology of orbital data mining: geological object recognition by artificial intelligence, erosion/deposition evolution models, clustering from multi-type of data… Oceanid objectives are to describe the early Martian sedimentary record accumulated below possible global ocean levels, to establish a fine-scale chronology of primitive events, to contextualize Mars2020 and ExoMars missions within the global ancient hydrological system and to correlate the oceanic context, the transient water cycle, and the mineralogy observed both from orbit and in situ.