Because of the aging of the population, the rising incidence of diseases, the needs for replacement or repair of bone tissues are growing steadily. In France, approximately 40,000 artificial knees and 150,000 hip prostheses are implanted each year. 10% required return, causing a second surgery. In this context, the number of implants, which contributes to health expenditure in France, is increasing (5% / year). By replacing a defective joint, the aim is to help the patients to quickly recover its autonomy / mobility and in a long-lasting way. Since the first hydroxyapatite coated HIPs were implanted in the mid-1980s, the clinical use of such implants has aroused many interests over the last decades. The current concerns are the capacity of the clinicians to have bioactive, antibacterial, mechanically stable coatings and to process them on any type of substrate whatever its composition or shape with a high degree of accuracy. The project objective is to develop coatings based on multisubstituted nanostructured calcium phosphates with an adjusted morphology, excellent short and long terms biocompatibility, very good adhesion on prosthetic materials and bactericidal properties. The project therefore aims at : i)assessing the potential of two new thermal spray processes (suspension plasma spray and cold spray) to develop these "smart" calcium phosphates as coatings; ii) adapting the methods to treat implants of various sizes, of complex shapes, and made of metallic materials, polymeric or ceramic; iii) describing the physical, chemical and structural effects of coatings on osteoinductive properties; iv)developing new experimental and numerical approaches to determine their mechanical properties (adhesion and cohesion). The proposed PRCE project entitled ArchiCaP « Architectured substituted calcium phosphate coatings for bioactive bone implants »brings together three academic research groups and a small company – CIRIMAT of the Institut National Polytechnique de Toulouse, LGP of Ecole Nationale d’Ingénieurs de Tarbes, and BioTis of the Université de Bordeaux and 2PS, SME dedicated to plasma sprayed coatings for orthopedic implants. The multidisciplinary consortium in materials science and engineering, biology and industrial systems will also rely on CRIOAC-GSO as well as on two international groups from Universities of Sherbrooke and Barcelona that are very well-known in the thermal spray field.