Cancer is the first leading cause of death by non-communicable diseases in children in Europe. During cancer treatment, patients’ morbidity is increased due to physical inactivity, cancer-related fatigue (CRF) and reduced health-related quality of life (HRQoL). Adapted exercise training in cancer patients, called exercise oncology, is an increasingly recognised, promising health care intervention. In adults, exercise oncology revealed notable effects on tolerance and completion rate of cancer treatment. However, in childhood cancer patients, strong evidence for exercise efficiency is lacking. Thus, precision exercise training is not part of standard care in paediatric oncology and does not reach the majority of patients. By pooling the leading expertise on a European and cross-Atlantic level, the FORTEe project aims to evaluate a personalised and standardised exercise intervention for children and adolescents undergoing anti-cancer treatment. In the randomised, controlled FORTEe trial, high evidence for an innovative, patient-centred exercise treatment will be generated. FORTEe promotes exercise oncology that aims at making patients “stronger to fight childhood cancer”. Supervised exercise training intents to increase muscle strength and reduce muscular atrophy due to bedrest. CRF and HRQoL can be improved and in the future, these benefits may help to fight childhood cancer by increasing therapy efficiency and survival rate. Within the project, digital, innovative technologies such as augmented reality will be developed and applied to make the exercise training more effective, age-adapted and personalised. Moreover, FORTEe will stimulate translational research to provide access to paediatric exercise oncology as a new health care intervention. As a progress beyond the current state-of-the-art, FORTEe has the ambition to implement paediatric exercise oncology as an evidence-based standard in clinical care for all childhood cancer patients across the EU and beyond.

EU-TRAINS aims to reinforce the supply chain on sensors for biomechanics and cardiovascular system real-time monitoring targeting applications in the fields of fitness and healthcare. It leverages from the strength of EU digital microsystem and design to support a 100% made-in-Europe supply chain of solutions which encompass smart-textile integration as well as advanced AI-based edge-cloud data processing. In details the following outcomes are foreseen: - Textile integrated electronic systems for real-time monitoring of hearth, respiratory and movement parameters on-the-air and in-water through an interdisciplinary approach; - Semiconductor technologies which allow the re-use of micro-nano systems both in the sports and in the healthcare sectors; - Miniaturized devices allowing the capturing of bio-chemical parameters able to withstand harsh ambient conditions such as salt fogs, chlorine, detergents, high and low temperatures, etc. The following key activities are targeted: - Development, prototyping and demonstration of versatile sensors with edge AI features for improved precision and reliability, that can also be integrated in textiles as well as in smart wearable wrist-watches and in sport equipment and gears targeting also underwater applications; - Cloud-edge Artificial Intelligence combined approaches for reliable diagnosis of body parameters. This will comprise sensor’s self-learning, remote update, multi-sensing approaches based on sensor arrays; - Novel materials that support electronics printing in textiles with stretchability and self-healing capabilities. Societal benefits are foreseen in the transition to a healthier lifestyle by promoting regular physical activity through affordable tools and services for a large audience, including people with disabilities. Moreover, this will impact the smart/remote-healthcare sector which will benefit of the availability of low-cost microfabricated solutions for intelligent, versatile, connected body sensors.

H2TRAIN proposal is funded on the sixth edition of the Electronic Components and Systems (ECS) Strategic Research and Innovation Agenda (ECS-SRIA) topics and major challenges for enabling digital technologies in holistic health-lifestyle supported by artificial intelligence (AI) networks. Biosensors for e-health and smart tracking of sport and fitness are a class of devices that is dominating the consumer and professional market with an unprecedented growth. Despite the impressive capabilities of recent approaches, several prospective revolutionary improvements are still open points, mainly in relationship with four factors: sensing new biosignals and tracking new activity patterns; improving battery lifetime and energy management for continuous use; and secure, reliable and efficient data analysis with AI algorithms and connectivity with the IoT. H2TRAIN aims at advancing the state of the art in this respect, taking profit from the remarkable properties and synergistic potential of one-dimensional (1D) and two-dimensional (2D) materials (1DM and 2DM), enabling more sensitive, efficient, and miniaturized biosensing capabilities within the established CMOS technology framework. This will contribute to the growth of e-health services assisted by AI and will fortify the development of Internet of Things (IoT) applications in health & wellbeing and digital society. H2TRAIN not only facilitates digital technology but also involves the development of new 1DM and 2DM-based devices for sensing, energy harvesting and supercapacitor storage. These innovations serve to integrate sport and health activities into IoT applications, making them accessible as wearable technology. H2TRAIN combines mature CMOS technology products for health and sport sensing with embedded intelligence as a cross-sectional technology. This combination offers a broad spectrum of technology demonstrators (TD) based on advanced sensors, such as tattoo sweat, C-reactive protein, cortisol and lactate.