MOEBIOS is an application of the circular (bio)economy concept: the development of three value chains incorporating separate recycling streams for bioplastics (BP’s) to improve waste management efficiency throughout Europe. It is a systemic innovation: it will create linkages addressed at the different key stages of the whole chains to solve a hierarchical challenge, from the collection of the bioplastic waste (simulated streams), up to the upcycling and validation of the final recycled end-products (holistic and coordinated solution). The new value chain will imply sorting, conditioning and valorising three types of waste streams from the packaging, agriculture and textile industries into three end-products, targeting to reach at least the same quality and functionality than the original grades, while the end users’ acceptance will be assessed as well. As cornerstone targets for maximizing project’s impact, the upscaling of the recycling processes will: (1) be integrated in pilot plants on the premises of actual industrial recycling lines currently operating in waste management companies, not disrupting them, and reaching a final TRL = 6/7 or even beyond. (2) focus on bioplastics for which recycling processes are still not in place, excluding bio-based analogues (“drop-ins”): PLA and PLA blends, PHA and its blends, PBS and PEF, accordingly with the market. The use of PBAT will be assessed as well. A Multi-Actor Approach (MAA) and a transdisciplinary methodology will engage waste producers, waste managers, bio-based and (bio)plastics industry, public authorities, standardization agencies, citizens and media multipliers, creating a co-creation and co-ownership innovation environment of + 50 participants.

The core of the project is focused on proposing sustainable processes from both an environmental and an economical point of view, being involved into the concept of circular economy. It is designed using an integrated biorefinery concept, which ensures a comprehensive use of material and energetic resources, while food residues are valorized, reusing valuable components at the farm and at industrial level. Innovative solutions to waste streams in the wine and fruit juice industries are looked for in this project, extracting medium to high-added value mixtures that are or can be used as ingredients, chemicals and additives in the food; chemical and cosmetic industries; or as plant immune-system elicitors in green-houses and farms, reducing the need for agrochemicals. Processes to value-added products from wastes are physical, chemical, physicochemical, enzymatic and microbiologic, and products will be tested for their antioxidant and plant immune system elicitor capacity, this latter at lab, pilot-plant and field scales. Therefore, the proposed strategies will reduce waste treatment costs, while improving economics at the food industry and farm levels. The consortium is well balanced considering the complementary scientific and economic background, expertise and capabilities (fundamental and applied research, laboratory, demonstration and production capacities, and public/industrial participation) of the partners to successfully address the ambitious project objectives. It is formed by eight partners from four European countries and comprises two universities (Complutense University of Madrid –Spain- and Université de Picardie Jules Verne –France-), two public research institutions (National Institute of Agriculture and Food Research and Technology -Spain- and Paper and Fiber Research Institute –Norway-) and four SMEs (ASA Spezialenzyme –Germany-, ELYS Conseil SASU –France-, Plant Response , and Pago de Carraovejas –Spain-).

The highly integrated INCENTIVE consortium represents true partnership between Indian and European/US groups that addresses the global health and economic challenge posed by influenza infections, to reduce the worldwide burden resulting from outbreaks. INCENTIVE’s strategic goals are to provide seminal knowledge on the underlying mechanisms of poor responsiveness to influenza vaccines in vulnerable individuals and advance the development of two next generation universal influenza vaccines. This is achieved by pursing the following specific objectives: 1) address the current knowledge gap by performing comprehensive immunome profiling of responders and non-responders to licensed influenza vaccines in infants, children, adults and elderly in parallel phase IV trials in Europe and India to identify the underlying mechanisms of vaccine responsiveness in different vulnerable populations and ethnical groups; 2) advance the development of two next generation universal vaccines, including an antigen presenting cell-targeted nucleic acid vaccine up to proof-of-concept for vaccine efficacy in non-human primates, and a computationally-derived second generation COBRA (Computationally-Optimized Broadly-Reactive Antigens) vaccine up to clinical development, comprising a phase I trial in Europe, a phase II trial in India and efficacy studies using an influenza controlled human challenge model; 3) identify predictive biomarkers of responsiveness to vaccination to develop new diagnostics; 4) implement comprehensive technology transfer and harmonization activities for immunological analysis and data integration; and 5) perform a health systems and investment analysis, and discrete choice experiments to assess the suitability of the developed technologies for low- and middle-income countries and to identify potential downstream constraints that might affect uptake by health care systems.

BUTTERFLIES aims to drive Europe towards sustainability and technological progress through Biointelligent Manufacturing, using biological systems to create innovative production technologies. Our project will achieve these aims by addressing challenges currently preventing widespread uptake of bio-polymers in advanced additive manufacturing (AM). The BUTTERFLIES bio-inspired advancements are based on chitin, one of the most abundant bio-polymers on Earth (second only to cellulose), and applied specifically to binder jetting (BJT) and 2 photon polymerisation (2PP) AM processes. Environmental sustainability will be achieved through chitin nanocrystal crosslinkers that bind chitin biopolymers in BJT and photocurable chitosan bio-polymer in 2PP. These approaches will offer streamlined production to replace petroleum-based plastics and non-environmentally friendly binders. BUTTERFLIES seeks to transform and revolutionise European manufacturing and products through seamless integration of biomaterials into additive manufacturing processes. BUTTERFLIES will address the challenges associated with the processing of biomaterials such as chitin and chitosan in processes such as binder jetting (BJT) and 2 photon polymerisation (2PP). Environmental sustainability will be achieved through low-temperature bio-based binders that will offer streamlined production to replace petroleum-based plastics and binders with chitin, the second most common biopolymer in nature. BUTTERFLIES will focus on development of smart bioproduct and hybrid manufacturing techniques through key technology developments: - BJT and 2PP for bio-intelligent 3D manufacturing to manufacture complex structures from biomaterials with embedded intelligence from bioprocesses and mimicry of real biological systems. -Novel biomaterial binders -Process design for BJ and 2PP-based 3D printing of biomaterials. -Process scalability of the 2PP technique based on laser beam shaping and multi-beam processing.

RECOVER is a disruptive RIA proposal built upon the actual needs to solve the contamination of agro-fields with non-biodegradable agro-plastics as well as to improve municipal waste handling by decreasing drastically the packaging fraction going to unsustainable waste management routes. We intend to reach our ambitious objectives applying biotech solutions that will include symbiotic bioprocesses between previously reported high powered microorganisms through microbiotic systems vectored by several insect species. Indeed, one of the main innovations in our proposal is the combination of endogenous and exogenous microorganisms and their inoculation on insects. This will allow achieving higher levels of biodegradation and direct conversion (at the same time) of agri-food plastic wastes in insect by-products such as chitin, that can be converted in chitosan (high value as bioplastics raw materials and other interesting industrial applications due to anti-microbial activity) that will be used in active packaging, enhanced mulching films and biofertilizers applications. RECOVER will help providing novel biotechnological solutions applying microorganisms, enzymes and insects to degrade conventional plastic packaging and agricultural films waste streams but also result in new feedstocks for the bio-based industries. The process will be optimized and performed either ex-situ in composting reactors (preferred route for non-recyclable plastics from municipal solid waste or for agricultural films that can be collected easily) or in-situ in the case of bioremediating soil pollution, by e.g. mulching films, further contributing to the long-term removal of non-biodegradable polymers from the environment. In addition, RECOVER can solve the microplastics pollution at the level of both industrial composting and soil.