Alcohol is enjoyed by many and while it contributes to the economy, it is also a major cause of early death, illness, lost work days, violence, social problems, relationship difficulties and inequalities. Governments can reduce these harms by taking action to make alcohol less affordable (price policy) and less easily available (availability policy), and by reducing how much it is advertised and promoted (marketing policy). Across the four nations of the United Kingdom (UK), and in Republic of Ireland (ROI), there have been many recent changes in these alcohol policies which have been heavily debated by campaign groups and politicians. There is a need for research to understand the intended and unintended effects of policies, not just on health, but on social, economic and cultural aspects. As Scotland introduced several new policies from 2005 onwards, and put in place extensive structures to support studies to explore their effects, a broad community of alcohol policy researchers has been coming together. The Irish government has recently passed a world-leading set of policies to reduce alcohol harms, but currently there are fewer researchers studying these policies in ROI/NI, and little contact between those who are. Scotland, Wales and Northern Ireland are also considering further policy changes. Whilst traditionally seen as a medical issue, it is clear that alcohol consumption and harms are affected by culture and politics. This network therefore proposes to bring together researchers from a wide range of social science and other backgrounds, and to draw others into the field, to deliver on the alcohol policy research needed in UK/ROI over the coming years. Our ACTIVITIES will focus on four themes: Availability, Marketing, Price & Politics and will include: 1) A website, blog and twitter feed; 2) A launch event with researchers and policy partners in Dublin; 3) Open seminars on each of the four themes, each hosted by a different university, with side meetings to build teams for future research; 4) Study visits for 4 selected early career researchers to spend time with more experienced colleagues; 5) A workshop to build capacity on alcohol policy research and give time for teams to develop funding applications; and 6) A UK/ROI open research symposium to which any researchers can submit abstracts to present their work, with invited speakers and free places for early career researchers. The network will be led by Prof. Joe Barry in ROI and Prof. Niamh Fitzgerald in the UK. NF is Professor of Alcohol Policy and specialises in studies drawing on expertise across different academic disciplines to better understand intended and unintended consequences of policy interventions. JB has worked in substance use for 30 years and chairs an expert group set up by the Minister for Health in ROI on which 3 academics from this proposal also sit. NF and JB are joined by 14 co-applicants from 13 institutions across the UK, from 10+ disciplines and with cross-cutting interests in the four themes. The bid will benefit from the active involvement of policy partners from government departments in NI, ROI and Scotland; and public health agencies across the UK. It will link into existing policy groups, including the UK/ROI British Irish Council, and the NI/ROI North South Alcohol Policy Advisory Group. The Institute of Public Health in Ireland, an all island body with a remit to inform public policy in both ROI and NI is an active partner and will provide administrative support to the network. We expect that the network will give rise to new research teams involving UK & ROI academics, and new alcohol policy studies focused within or across the four policy themes. With our partners, we will actively plan for the future of the network beyond the funded period.

The number of people worldwide living with dementia and cognitive impairment is increasing, mainly due to people living longer, so we want to figure out how where we live affects dementia and brain health as we get older. Some research suggests that where we live might influence our brain health. For example, poor air quality in towns and cities, can lead to a decline in brain health. As more of us now live in towns and cities, it is important that the environment where we live is scientifically designed and improved to maximise our brain health. The complex social and physical environments where we live make some people more vulnerable than others to developing cognitive impairment. In other words, the factors that account for who is most likely to develop cognitive ill-health due to the environment has less to do with 'how' we live and more to do with 'where' we live. We do not know how these factors interact to make urban environments a problem for brain health, nor which are the best policies and interventions for promoting healthy ageing and brain health for our poorest communities. Our project will provide evidence for policies and practices that provide supportive urban environments to promote healthy ageing, including promoting brain health. This could include using creative urban designs to support people to adopt and maintain healthier lifestyles such as being more active. However, this needs a strong evidence base with expert community advocates who can articulate how supportive urban environments can improve brain health. Our research has the following steps: 1. First, with the help of stakeholders, including those from business, industry, and local government, and a review of existing research, we will represent the relationships between our biology, our lifestyles and our environment in a diagram illustrating how they likely interact to affect brain health, because visual thinking can help stakeholders better identify possible intervention sweet-spots to improve brain health. 2. By analysing data from over 8,000 older people in Northern Ireland, and linking this to information about where they live, such as the amount of air pollution, the toxins in soil, or how walkable their neighbourhoods are, we will explore how different environmental factors relate to brain health. 3. Next, we will collect new data on a subgroup of 1,000 older people including more in-depth measures of brain health and better measures of physical activity, using GPS devices worn around the waist that monitor our locations. This will allow us to explore how the urban environment influences our brain health. 4. Then, we will explore how aspects of our biology play a role in how the urban environment affects our brain health. 5. We will host workshops with local citizens to 'sense-check' our findings and co-develop promising prevention approaches. In these, we will explore the acceptability, affordability, feasibility and sustainability of new initiatives to improve the environmental influences on brain health. This might include, for example, policies on: expanding the car-free areas of the city to reduce air pollution; increasing the number of footpaths and cycle paths to encourage walking and cycling; improving public transport to reduce car use. As a result of our research we will produce: 1. A map of the system in which our genes, lifestyle behaviours and urban environments interact to affect brain health, to help guide stakeholders towards policies and programmes that can improve brain health. 2. An evidence base exploring how where we live affects our brain health. 3. A suite of potential policies and interventions to improve brain health and promote healthy ageing 'tested' (in terms of acceptability and feasibility) with older people, business, industry, policymakers and other stakeholders.

A recent public health strategy published by the Department of Health, Social Services & Public Safety entitled 'Fit and Well - Changing Lives (2012-2022)' [1] has shown that people with a learning disability (LD) represent one of the most vulnerable and disadvantaged groups in Northern Ireland (NI). In fact evidence shows that those with a LD across the United Kingdom (UK) are more likely to experience major illnesses, to develop them earlier, and die of them sooner than the population as a whole [2]. Furthermore, even with such a worrying health profile, the LD population is less likely to get some of the evidence-based annual health checks and treatments they need, and continue to face real barriers in accessing services [1] [3]. Most alarming however is the apparent invisibility of LD. Evidence suggests that such inequity often exists and persists among this population because they remain unseen [4]. At present there is no central register detailing the actual number of individuals with LD in NI. As a consequence it is not possible to evaluate the form, context or degree of inequality that may be experienced by this group. This in turn makes it impossible to tailor or to target services or to monitor health in terms of health inequalities for this population. Recently, a 'Research and Information Service Paper' submitted to the Northern Irish Assembly [9] noted that "...according to a review by Marmot in 2010 [10], health inequalities are avoidable and socially unjust...[and]...in order to reduce the steepness of the social gradient in health...actions must be universal, but with a scale and intensity proportionate to the level of disadvantage. Therefore, policies and strategies should target action at those experiencing greater social and economic disadvantage. This approach is termed 'proportionate universalism' [11] and it requires multi-agency working across local and central government, and the voluntary and private sectors" [12]. To begin to pursue and achieve proportionate universalism for the LD population of NI, a multi-disciplinary team comprising academic researchers from Ulster University (UU), University of Bristol (UofB) and senior representatives from the Public Health Agency (PHA), the Health and Social Care Trusts (HSCTs) the statutory sector (ARC, Positive Futures) and a LD service user group (COMPASS) aim to exploit, link and maximise the use of existing NI administrative data to (i) begin to expose, exploit and explore LD records wherever they reside in existing Northern Irish (NI) administrative datasets (ii) begin to consider best practice in, and strategize for, the future recording and identification of LD in NI (iii) formulate guidelines to tailor, target and implement support for individuals with LD across NI and (iv) establish an administrative data evidence base upon which to build future research, facilitate future data sharing and enable ongoing action to reduce the health inequalities faced by the LD population in NI. Specifically the study aims to (i) provide a geographical map of LD in NI using available Census data; (ii) profile the demography of the LD population using a range of socio-economic metrics; (iii) profile morbidity and comorbidity of health care problems among the LD population using the Enhanced Prescribing Database and Census health metric data; (iv) exploit NI Mortality data to explore the causes and contexts of death among the NI LD community and (v) stimulate and facilitate 'proportionate universalism' across the region through multi-agency collaboration across local and central government, and the voluntary and private sectors. While the LD population and the project's non-academic partners, the statutory (PHA and NHSCT) and voluntary (ARC, Positive Futures, COMPASS) sectors, will be the primary beneficiaries of the research, the team will also strongly influence how policy is commissioned, and how health care and health promotion services are delivered.

Those living in low-income areas have a much higher risk of long-term conditions such as diabetes, heart disease, depression, and frailty. Our lifestyle, such as how active we are, what we eat and if we smoke or drink alcohol in excess can greatly increase our chance of having one of these diseases. The environment that we live in, such as if we live close to or visit parks, canals, and forests, can help us live a healthier life. However, communities living in low-income areas can have poorer access to such spaces or use them less. They also have less voice in decisions affecting their local spaces, at either local or national level. We propose a new partnership: researchers, clinicians, practitioners (such as urban designers) and policymakers all working with local citizens who have the most to benefit from better access to and use of quality spaces. We will work collaboratively to identify poor quality and underused spaces through citizen-led approaches. We will then work with them to develop and/or modify outdoor spaces so that they are high quality and fit for purpose. These actions can be as small as window boxes in schools, or as large as the development of new greenways or reshaping policies regarding land use to protect our green spaces. We will also work to identify ways in which we can promote such spaces for everyone, ensuring that no community is excluded form benefit. The important aspect is that local communities are fully involved in decisions about what they want, and what they will use, thus becoming central to the decision-making process. They will also be involved in the evaluation of these actions, enabling them to directly see how the process has benefited their communities. An important part of putting actions and solutions in place is understanding if they work (or not). Data plays an important part in measuring success, particularly if the same data can be collected consistently across the different actions. Another part of the partnership will be establishing a way of bringing multiple sources of data together so we can effectively determine what works across multiple projects and settings. So, whilst citizens can be involved in collecting data about whether the space has improved their health and wellbeing (through a bespoke app), we can also use other data on health, wellbeing and the environment that is routinely collected by local councils and governments. The main research will take place in three different cities - Edinburgh, Belfast and Liverpool - all with some similar features (such as large urban areas with lower income communities) and distinct features (such as geography and culture). Each city already has policies and programmes in place to improve green and blue space, but there is much room for improvement. Working with the local citizens we will test a range of different methods and approaches, and be able to collect a large amount of data. This data can then be used to understand what works for whom and why across the cities. We can then use this knowledge to predict what could be effective over a much wider area, and also what does not work. We can also make some decisions around what is good value for money, and what is not. We also understand that individual small actions within local communities (or even within cities) are not going to solve the problem, which is why we are also going to focus on how our research can help inform future policies and programmes. Our programme of work will take a whole life course approach which will ensure inclusive environments for all; working with our youngest citizens in particular will ensure early cultural change levers are activated, empowering a new generation with lifelong health and wellbeing.

Understanding human behaviour and how it shapes organisations, communities and societies is needed to address global challenges such as the environmental, economic and health crises that we face now and in the future. Currently, behavioural research is not well coordinated in the UK. It also doesn't always ask the right research questions, involve people with the best skills, make good use of existing data, take advantage of innovative research methods or produce findings that can be used to make positive changes. The Behavioural Research UK Leadership Hub (BR-UK) will change this. BR-UK brings together a team from England, Scotland, Wales and Northern Ireland that includes experienced researchers from many different backgrounds and partners from government, the wider public sector, charities and businesses. We will work with communities to better understand behaviour and conduct research to improve lives and livelihoods. BR-UK will deliver a detailed work programme for the first 18 months. At the same time, we will expand our initial plans for the longer term to be reviewed by the funder, the Economic and Social Research Council (ESRC). In the first 18 months, we will: - Carry out a scoping study to look at needs, priorities and opportunities for behavioural research and set up a national network of researchers and research users - Determine how behavioural research can be more sustainable to make the best use of available funding - Identify (with our international advisory board) under-used global evidence as well as methods and theories to improve behavioural research excellence - Conduct 'demonstration projects' to show how the team can work together to use existing data and speed up the application of models and frameworks to provide rapid results. Topics include how behavioural advice was used during the Covid-19 pandemic, how we address some current issues like speeding on our roads, how to combine large amounts of data more efficiently and how well public support for different policies to help tackle climate change can be transferred between countries - Set up & test a responsive-mode consultancy service where organisations can ask questions about how behavioural research could help them with their policies or practices, and be matched to team members with relevant expertise. Looking ahead, BR-UK will organise our work around four Work Packages (WPs) and Themes (T). Work Packages are about HOW we will do things, and our Themes are about WHAT we will focus on. These are: WP1: Capability Building; WP2: Data and Technology; WP3: Methods and Evidence Synthesis; WP4: Engagement and Involvement; T1: Environment and Sustainability; T2: Health and Wellbeing; T3: Resilient Communities: and T4: Organisations, Markets and the Economy. We will conduct new studies across WPs and Themes. Examples of research questions to illustrate the range are: how to better use mobile phone technologies to engage people long-term to stop smoking or reduce their alcohol consumption; how to help regulators and the police keep children safer online and tackle internet crime; how to help people and organisations shift to transport that is better for the environment; how best to work with local and national governments to better understand the needs of their local communities when making policy decisions. As a Leadership 'Hub', BR-UK will work with other parts of the programme ('spokes' including a centre to train students and early career researchers as they develop. We will be flexible, and reserve part of the funding that could lead to new studies when sudden events like a new threat, emergency or event occur. We are well positioned to carry out rapid reviews of existing research to help governments and organisations know what behavioural evidence exists to inform decisions, and to identify evidence gaps. We will be ready to adapt and bring in new members with skills and experience that are most needed as BR-UK evolves.