EcoeFISHent demonstrates a replicable systemic and sustainable cluster for territorial deployment of the climate-neutral circular economy by creating six multilevel and synergic circular value chains (CVC) interconnecting blue- and green-economies to reconcile human industrial and economic activities with marine ecosystems and marine protected areas. The EcoeFISHent innovative bio-mass pre-treatment and extraction technologies will enable sustainable and efficient exploitation of fish processing side-streams (FPS) by obtaining bio-actives and galantine for high value-added food supplements and skin care products, biodegradable and compostable barrier layer for food packaging. Other fishing- and fish-industry side-streams (FFS) will undergo the Black Soldier Fly bioconversion to yield innovative soil fertilizer, oil for biodiesel and chitin for cosmetic applications. End of life fishing nets from aquaculture and fisheries will be recycled and converted into automotive polymer-based components and into packaging for cosmetic products. The multilevel interconnected cluster will be managed by a cloud-based platform communicating with physical IoT systems enabling safe and efficient operation of the logistic and transport infrastructure. The cluster busines model and the cluster digital twin will allow simulating critical and optimal scenarios for quantitative analysis of cluster performance measured by dedicated KPIs, also enabling the assessment of the cluster replicability in other geographic areas and fostering investments pipelines. Community and stakeholder?s involvement will be promoted also in the implementation of specific actions for marine ecosystem preservation by modeling, application of better practices and technologies for strongly reducing by-catch and for stopping ghost gears. Social and justice inclusion programs will be implemented by employing disadvantaged individuals, to increase overall cluster employment and to apply distributive justice criteria