There is a real need today to train experts in the whole process of inflammation with a comprehensive understanding of this natural and beneficial response of the organism that is also so frequently central to acute and chronic human disease states. With this aim in mind, we propose to train 15 promising young scientists, through a combination of individual research projects, collaborative efforts and coordinated training, thereby providing a strong theoretical / knowledgebase and competencies in relevant laboratory-based techniques. The research objectives of the training are the following: • Understand how inflammatory signals are detected by dedicated receptors, how these signals reach the inflammasome platform, and how downstream signals are propagated and serve in feedback mechanims • Develop genomic and transcriptomic approaches to understand the genetic bases of human inflammatory disorders and inform therapeutic strategies • Develop new in vivo imaging strategies in animal models, not only to describe the behaviours of the cellular actors of inflammation, but also to dissect the genetic basis of inflammatory processes and test anti-inflammatory drugs • Develop original mathematical and modelling tools, to analyse both the wealth of data generated, and to inform the development of models with which to understand inflammatory processes, and tools for physicians to understand the pathological basis of human disease This training frame is by design interdisciplinary, involving scientists from very different fields of biology (structural biologists, imagers, immunologists, geneticists), as well as mathematicians, programmers and modellers. We have made a particular effort to ensure that the proposed training frame be intersectorial, to maximise the possibility that the spin-offs of such a scientific program will reach the patient through the fostering of dedicated business enterprise initiatives. The programme will involve both technical training, so that all recruited PhD students reach a common level of expertise allowing real interdisciplinary collaborations, and complementary / transferable skills enabling the development of successful scientific careers - in both the academic and industry spheres. Importantly, recruited PhD students will also be trained to communicate their work, not only to their peers, but also to the general public, since we recognised the critical importance of informing and raising the scientific awareness of the general public. This will be achieved through scientific articles, Wikipedia articles, a MOOC, Lego tools and serious games. To our knowledge, this is the first European network set to meet the challenges outlined here, and we believe that the proposed programme will contribute to the training of future European leaders in this interdisciplinary field.