Radiotherapy kills cancerous cells by repeatedly targeting a tumour with high energy radiation. Although image assisted pre-treatment planning based on CT is performed to minimise the amount of healthy tissues being irradiated, the planned treatment is delivered in a manner that is effectively blind, because there is no monitoring of the patient motion and internal anatomy during radiation treatment delivery and no, dynamically modelled, consideration of possible body change during treatment period. This uncomfortable state of affairs persists worldwide, despite complex new treatments and image guided radiotherapy (IGRT) which members of the consortium helped to develop. Furthermore, there is a concern on the additional imaging radiation dose to the patient from the IGRT. Hence, the MEGURATH project was proposed to introduce metrology guided radiotherapy (MGRT), where the patient is measured, imaged and modelled during treatment delivery via optical sensing to provide non-invasive, radiation-free, real-time 3D patient position monitoring, and dynamic deformation modelling to determine the internal anatomical changes. The project is considered as a significant one with a leap forward approach for a grand challenge, and has attracted interest from Elekta Oncology Systems, Philips Medical Systems, VisionRT and NHS-IP.The MEGRATH programme consists of not only comprehensive research activities with diverse theoretical topics, but also translation of science and technology to the first purpose built IGRT research facility in the UK at the Christie Hospital, and the support of clinical studies selected from breast, lung, bowel, prostate and bladder cancers. The project is expected to make a world class contribution to radiotherapy by increasing our understanding of tumour target and organ at risk behaviour, treatment delivery and control of their impact on cure and complications. The marriage of anatomical modelling and dynamic 3D measurement on demand 'in-treatment', using light rather than ionising radiation like X-rays, will offer the opportunity to gain the pole position in engineering and computational science for oncology. The Collaborating for Success through People call is a valuable opportunity to support, complement, utilise and extend the MEGURATH project, thereby enabling the consortium to maintain, defend and widen its lead.The proposed programme of people-based activities starts with exploratory mutual visits by the PIs and group leaders for exchange of knowledge, creation of ideas and development of active collaboration, followed by two-way investigative short visits and relatively long research visits by researchers for synergistic development, cross application and performance evaluation of promising approaches, and finished by a workshop to provide a venue for the consortium to lead the development of a joint EU project proposal with the participating partners. To provide significant added value to the MEGURATH project in terms of scientific knowledge and new clinical applications, 7 eminent research groups and 1 leading 3D equipment company are selected for participation in the proposed people-based activities:-Two from Poland: Telemedicine Group from AGH University of Science and Technology, and Department of Scientific Information from Jagiellonian University Collegium Medicum;-Three from France: one from the French National Institute for Research in Computer Science and Control (INRIA), and the other two from National Centre for Scientific Research (CRNS), namely, Lyon Research Centre for Images and Intelligent Information Systems (LIRIS) and Signal and Image Processing Research Laboratory (ETIS);-One from Germany: Institute for Electronics Signal Processing and Communications (IESK) at Otto von Guericke Universitt Magdeburg; -One from Italy: Signals and Images Laboratory from the National Research Council (CNR); and-3dMD with the company headquarters in the USA.

Metallic materials are indispensable to modern human life. From everyday items such as aluminium drinks cans, to advanced applications like jet engine turbine blades and the pressure vessels of nuclear reactors, the positive social impact of metals is difficult to overstate. Yet despite major advances in our understanding of the manufacture and properties of metals, significant challenges remain. Constructing the next generation of electric cars will require improved lightweight alloys and joining technologies. Development of fusion power plants, which will provide near-limitless carbon-free energy, will require the development of advanced alloy systems capable surviving the extreme environments found inside reactors. For the next generation of hypersonic air and space vehicles, we require propulsion systems capable of over Mach 5. Alloys will need to survive 1800 degrees Celsius, be made into complex shapes, and be joined without losing any of their properties. Overcoming these challenges by improving existing metallic materials, developing new ones, and adapting manufacturing methods, then the benefits will be substantial. Now is a particularly exciting time to be involved in metallurgical research and manufacturing. This is not only because of the kinds of compelling challenges specified above, but also because of the opportunities afforded by the emergence of new advanced manufacturing technologies. Innovative techniques such as 3D printing are enabling novel shapes and design concepts to be realised, whilst the latest solid-state processes allow for the design and production of bespoke alloys that cannot be made by conventional liquid casting techniques. Industry 4.0, or the fourth industrial revolution, provides opportunities to optimise emerging and established technologies through the use of material and process data and advanced computational techniques. In order to fully exploit these opportunities, we need to understand the complex relationships between the processing, structure, properties and performance of materials, and link these to the digital manufacturing environment. To deliver the factories of tomorrow, which will be critical to the future strength of UK plc and the wider economy, industry will require more specialists with a thorough understanding of metallic materials science and engineering. These metallurgists should also have the professional and technical leadership skills to exploit emerging computational and data-driven approaches, and be well versed in equality and diversity best practice, such that they can effect positive changes in workplace culture. The EPSRC Centre for Doctoral Training in Advanced Metallic Systems will help to deliver these specialists, currently in short supply, by recruiting and training cohorts of high level scientists and engineers. Through collaboration with industry, and a comprehensive training in fundamental materials science and computational methods, professional skills, and equality and diversity best practice, our graduates will be equipped to become future research leaders and captains of industry.

Metallic materials are used in an enormous range of applications, from everyday objects, such as aluminium drinks cans and copper wiring to highly-specialised, advanced applications such as nickel superalloy turbine blades in jet engines and stainless steel nuclear reactor pressure vessels. Despite advances in the understanding of metallic materials and their manufacture, significant challenges remain. Research in advanced metallic systems helps us to understand how the structure of a material and the way it is processed affects its properties and performance. This knowledge is essential for us to develop the materials needed to tackle current challenges in energy, transport and sustainability. We must learn how to use the earth's resources in a sustainable way, finding alternatives for rare but strategically important elements and increasing how much material we recycle and reuse. This will partly be achieved through developing manufacturing and production processes which use less energy and are less wasteful and through improving product designs or developing and improving the materials we use. In order to deliver these new materials and processes, industry requires a lot more specialists who have a thorough understanding of metallic materials science and engineering coupled with the professional and technical leadership skills to apply this expertise. The EPSRC Centre for Doctoral Training in Advanced Metallic Systems will increase the number of metallurgical specialists, currently in short supply, by training high level physical science and engineering graduates in fundamental materials science and engineering in preparation for doctoral level research on challenging metallic material and manufacturing problems. By working collaboratively with industry, while undertaking a comprehensive programme of professional skills training, our graduates will be equipped to be tomorrow's research leaders, knowledge workers and captains of industry.