The project ‘Climate smart, ecosystem-enhancing and knowledge-based rural expertise and training centres’ (RURALITIES) delivers an ecosystem-enhancing and climate action driven expertise and learning framework organised in hubs e.g., the ‘RURALITIES’, comprising a series of innovative methodologies with the learner at its core, supported by a comprehensive network of living labs, and a digital platform combining the Internet and wireless technologies, to assist engage, connect and empower actors. This is done via a multi-point approach e.g., multi-actors, multi-disciplines, multi-systems, multi-scale, multi-sectors, and multi-levels. RURALITIES is rooted in the recruitment, preparation, training and coaching of 1.000+ facilitators (KPI) distributed in all participating countries, for a variety of tasks (e.g., trainers, facilitators, role models, hub coordinators, etc.), and who play a significant role in creating the matrix and the platform upon which the learning framework is built, develops and evolves. RURALITIES proposes to ideate, implement, futureproof, validate and deliver the aforementioned expertise and learning centres via real-scale practicing in 6 simplified rural socio-ecological systems (SIMSES) e.g., demonstrators, 2 in Italy, 1 in the United- Kingdom (UK), 1 in Slovenia, 1 in Spain and 1 in Romania. RURALITIES coordinates identified actions of local, regional authorities in supports of rural innovation in regions and economic sectors where rural innovators are not yet engaged in a relevant network. RURALITIES coordinates identified SIMSES networks promoting rural innovation solutions whilst establishing innovative multipoints ‘RURALITIES Hubs’ of expertise and training on rural innovation. This is done via coordinating action for the managing authorities and regional bodies influencing regional and national policy instruments in Italy, the UK, Slovenia, Spain and in Romania.

The framework 'P4 Medicine' (predictive, preventative, personalized, participatory) was developed to detect and prevent disease through close monitoring, deep statistical analysis, biomarker testing, and patient health coaching to best use the limited healthcare resources and produce maximum benefit for all patients. However, we have seen only few feasible examples over the past 10 years. The Finding Endometriosis using Machine Learning (FEMaLe) project will revitalise the concept to develop and demonstrate the Scalable Multi-Omics Platform (SMOP) that converts multi-omic person population datasets into a personalised predictive model to improve intervention along the continuum of care for people with endometriosis. We will design, validate and implement a comprehensive model for the detection and management of people with endometriosis to facilitate shared decision making between the patient and the healthcare provider, enable the delivery of precision medicine, and drive new discoveries in endometriosis treatment to deliver novel therapies and improve quality of life for patients. We will rely on participatory processes, advanced computer sciences, state-of-the-art technologies, and patient-shared data to deliver: 1) mobile health app for people with endometriosis, 2) three clinical decision support (CDS) tools for targeted healthcare providers (risk stratification tool for general practitioners, multi-marker signature tool for gynaecologists, and non-invasive diagnostic tool for radiologist), and 3) computer vision-based software tool for real time augmented reality guided surgery of endometriosis. Health maintenance organisations (HMO) expect to be able to reduce overall cost of treatment by at least 20%, while improving patient outcomes, using CDS tools. The SMOP will be based on open protocol, embedded in all ethical and legal frameworks, to enable tailored and personalised usage to improve the lives of patients across Europe beyond the project period.