There is a high demand to design approaches capable of tracking the origin of biomarkers in complex biological environments, in the areas of life, environmental, food and forensic sciences. Metabolomics and Fluxomics show great promises towards this aim, and a high potential arises from their combination with Isotopic fingerprinting at natural abundance. The resulting isotopomics approach requires cutting-edge analytical tools, and Nuclear Magnetic Resonance (NMR) is currently the only generic technique giving access to the site-specific isotope content at natural abundance. The detection of very small relative variations between samples originating from different (bio)chemical pathways is possible through 13C isotopic NMR, which can however only be applied to simple and concentrated samples, due to its low sensitivity. Consequently, numerous applications are out of reach. To tackle the current limitations of 13C isotopic analysis, SUMMIT will develop a groundbreaking analytical workflow relying on two of the most powerful NMR methods: dissolution dynamic nuclear polarization and ultrafast 2D NMR. This cutting-edge approach will allow the simultaneous measurement of 13C fingerprints from multiple low-concentrated biomarkers in complex mixtures, which is impossible with existing methods. The high potential of this analytical strategy will be demonstrated on a relevant biological study, the investigation of breast cancer cell metabolism, through applications with gradually increasing risk levels. These approaches will make it possible to identify (i) new biomarkers to discriminate between cell lines expressing different hormonal receptors; (ii) novel potential therapeutic targets from the elucidation of metabolic pathways. Beyond this application, the project will have a high impact on a wide community of academic and industrial researchers, covering unmet needs from life sciences, food industry and forensic analysis.

Eight hundred and fifty million people worldwide are currently affected by chronic kidney disease (CKD), which is also the 11th leading cause of mortality worldwide. CKD can occur from a multitude of causes including diabetes and high-blood pressure. Moreover, recent clinical and experimental studies have shown that CKD is closely interconnected with acute kidney injury (AKI) as well. Currently available in vitro models show limited relevance to study AKI, especially drug- and virus- induced AKI, due to the poor functionality and relevance compared to a diseased human tissue. BIRDIE aims at developing three-dimensional (3D) in vitro human renal tubulointerstitium (TI) models to enable viral infection and nephrotoxicity studies while creating a robust platform to address other diseases and treatment innovations in the future. Two enabling technologies, bioprinting and organ-on-chip, will be combined to build a microphysiological relevant TI model. Primary human cells and induced pluripotent stem cells will be used to generate kidney models, and combined with the aforementioned techniques model envisioning a reliable screening platform for future patient specific therapies. Our ambition is to create a new 3D renal in vitro model allowing an unprecedented degree of mimicry and function compared to a human kidney. While developing the model focusing on the applications mentioned before, our goal is to make it broadly applicable to the multitude of kidney-related diseases.

EUniWell’s mission is to contribute to the well-being of society, the planet and of the academic community - by steering research, innovation and education programmes towards contemporary societal challenges. During the preparation of the 2nd EUniWell E+ proposal, EUniWell has update its research priority areas, which provide the agenda of our 5 Research Arenas: • Health and Well-being • Social Equality and Well-being • Environmental Change and Well-being • Well-being in Teaching Future Generations • Culture, Multilingualism and Well-being. EUniWell#research: • sets up the conditions for a coordinated EUniWell research agenda, creating both the leadership and the digital collaborative working conditions and infrastructures for research on the promotion of well-being. Expert focus groups feed this strategy, and the Well-Being Incubator is set up to catalyse joint inter-/transdisciplinary research solutions to the complex well-being challenges . • taps into the potential created by the new, European scale of action to accelerate the digital and green transitions and the implementation of Open Science approaches with respect to FAIR data, digital method and infrastructure sharing. Because Open Science is about the science-society interface, we will provide specific training modules to our staff so that outreach beyond academia is a natural part of their research activity. • caters for the need of transversal career support for researchers, also with two key moments in mind: the early-career stage and then access to leadership roles. The EUniWell Skills Taxonomy ensures that the skills we develop are aligned with our well-being agenda and also the needs from our external partners. The EUniWell Research Training Academy promotes transversal skills as crucial elements of a balanced career development, fostering well-being among our staff.

The overall objective of the project is to establish a top-level scientific network of several institutions and research groups from Europe and Africa on the field of slavery studies. It aims at focusing mutual efforts of 13 partners with extended and complementary competences in their respective research fields and at gathering multidisciplinary expertise in slavery-related issues by encouraging the exchange of young and senior researchers from both continents. This network will be the first of its kind in the world. Our goal is to conduct research on both historical and contemporary slavery and forced labour and to emphasize its international dimension. One of the main goals of this project is to bridge disciplinary and regional area studies or initiatives, to encourage dialogue and to engage in collaborative research. It will involve African and European researchers from various disciplines from different parts of the world with complementary skills. It will enrich the analysis of the underlying local situations and address the impact of slavery and slave trade on population histories in Europe and Africa. This project is composed of three components (training, research, diffusion) and aims to address the main objectives of the RISE programme such as: - The promotion and support scientific and technological cooperation between African and European researchers working in research institutions and universities; - The development of new collaborative linkages that will result in innovative ideas; - The building of the capacities of junior researchers; - The encouragement of exchanges and synergy between researchers, by supporting their mobility and establishing a sustainable network and reach out various communities within and outside academia.

“The European Qur’an” (EuQu) will study the place of the Muslim holy book in European cultural and religious history (c.1150-1850), situating European perceptions of the Qur’an and of Islam in the fractured religious, political, and intellectual landscape of this long period. The Qur’an plays a key role not only in polemical interactions with Islam, but also in debates between Christians of different persuasions and is central to the epistemological reconfigurations that are at the basis of modernity in Europe, from Iberia to Hungary. The Qur’an is deeply imbedded in the political and religious thought of Europe and part of the intellectual repertoire of Medieval and Early Modern Europeans of different Christian denominations, of European Jews, freethinkers, atheists and of course of European Muslims. We will study how the European Qur’an is interpreted, adapted, used, and formed in Christian European contexts – often in close interaction with the Islamic world. EuQu will produce, over a six-year period: 1. A GIS-mapped database of the European Qur’an, containing extensive information about Qur’an manuscripts and printed editions (in Arabic, Greek, Latin, and European vernaculars) produced between 1143 and 1800 as well as prosopographical data about the principal actors involved in these endeavours (copyists, translators, publishers). 2. A series of publications: PhDs, monographs written by postdocs and PIs, special issues of academic journals, and animated digital publications for a wider audience and educational uses. They will make key breakthroughs in their fields, dealing with aspects of the transmission, translation and study of the Qur’an in Europe, on the role the Qur’an played in debates about European cultural and religious identities, and more broadly about the place of the Qur’an in European culture. 3. A major exhibition during the final year of the project, “The European Qur’an” to be held at museums in Nantes, London, Budapest and Madrid.