Given the continuous rise of diet-related chronic diseases worldwide, our timely translational project SINFONI, gathering international pluridisciplinary academic and industrial experts, develops a multifunctional anti-inflammatory dietary approach to improve cardiometabolic risk profile. Our novel concept will simultaneously target metabolic endotoxemia and inflammatory status balance, gastrointestinal barrier integrity and gut microbiota, food glycaemic response and cardiometabolic profile. Based on strong preliminary works from its partners, SINFONI proposes a highly innovative science-based approach for the industrial development of food products allowing 1) to investigate the synergistic impact of combining different bioactive food concepts (polyphenols, bioactive lipid, modified starch) to modulate low-grade inflammation and related cardiometabolic risk profile 2) to monitor early postprandial and low-grade inflammation multi-biomarkers signature by a specific dynamic experimental design, and 3) to develop and validate a range of novel multifunctional food products by selecting specific ingredients’ validated properties as effective synergistic tools to promote relevant changes in inflammatory status, gut microbiota and related cardiometabolic risk factors. SINFONI will explore most recent food technologies for targeted delivery of bioactive food components in order to design several food products that can be easily implemented in everyday diet to provide sufficient bioactive compounds, optimal matrix and ensure optimal taste.