intoDBP will create innovative tools and strategies to improve water quality management for safe human use and a healthy environment. It focuses on catchment protection and forecasting, transformative drinking water treatment, and real-time monitoring to combat the effects of climate and global change. In particular, intoDBP focuses on pollution and risks related to disinfection by-products (DBPs). By developing and applying advanced, integrated, and cost-effective sensors and analytical methods, intoDBP will expand knowledge on water quality and DBP precursors to better understand its formation and human exposure in Europe. intoDBP monitoring results will feed into numerical forecasting tools to predict source water changes and formulate climate change adaptation pathways at catchment and treatment scale. intoDBP also develops transformative options for advanced and cost-effective upgrade of water treatment and disinfection. In the intoDBP consortium researchers, small and large enterprises, communication experts and public services join forces to generate interdisciplinary solutions, that will generate a renewed perspective of drinking water surveillance, support decision-making and governance, and increase system resilience. intoDBP will implement and validate its cross-cutting products in four complementary case studies from three European countries where compliance with DBP regulation currently is an acknowledged challenge. The direct and visible positive impact of intoDBP in the case studies will foster rapid product adoption at a European and global scale, thus strengthening Europe’s position and role in the global water market. Reaching out beyond the water sector itself, intoDBP will directly engage society through surveys to analyse exposure to DBPs, collect data about catchment protection initiatives, create awareness and promote sustainable consumer behaviour such as reducing bottled water consumption.