This project proposes to investigate the way the polymeric powders of different shapes and sizes flow, interact and sinter in the Laser Sintering process, through modelling and experimental validation. Laser sintering is part of the additive manufacturing technology, known for its benefits in industries where custom made products, lightweight and complex designs are required. In laser sintering a polymer powder bed is heated to just below its melt temperature. A laser is then focused onto the bed which scans a raster pattern of a single layer of the final part. The bed lowers slightly and a new layer of powder is applied. The process is then repeated until the component is made and the additive layer process is complete. The spreading and compaction of the powder is an important part of the LS process, a non-uniform layer of powder leads to high porosity and weaker bonding between layers and therefore a structure with poor mechanical performance. Similarly, the size and shape of particles can change the sintering process. Larger contact areas between particles lead to a good sintering profile and ultimately to a high density part and good mechanical properties. Surface area of particles, polymer viscosity and surface tension are characteristics which will be considered when modelling the flow and sintering process.

Graphene has many record properties. It is transparent like (or better than) plastic, but conducts heat and electricity better than any metal, it is an elastic thin film, behaves as an impermeable membrane, and it is chemically inert and stable. Thus it is ideal for the production of next generation transparent conductors. Thin and flexible graphene-based electronic components may be obtained and modularly integrated, and thin portable devices may be assembled and distributed. Graphene can withstand dramatic mechanical deformation, for instance it can be folded without breaking. Foldable devices can be imagined, together with a wealth of new form factors, with innovative concepts of integration and distribution. At present, the realisation of an electronic device (such as, e.g., a mobile phone) requires the assembly of a variety of components obtained by many technologies. Graphene, by including different properties within the same material, can offer the opportunity to build a comprehensive technological platform for the realisation of almost any device component, including transistors, batteries, optoelectronic components, photovoltaic cells, (photo)detectors, ultrafast lasers, bio- and physico-chemical sensors, etc. Such change in the paradigm of device manufacturing would revolutionise the global industry. UK will have the chance to re-acquire a prominent position within the global Information and Communication Technology industry, by exploiting the synergy of excellent researchers and manufacturers. We propose a programme of innovative and adventurous research, with an emphasis on applications, uniquely placed to translate this vision into reality. Our research consortium, led by engineers, brings together a diverse team with world-leading expertise in graphene, carbon electronics, antennas, wearable communications, batteries and supercapacitors. We have strong alignment with industry needs and engage as project partners potential users. We will complement and wish to engage with other components of the graphene global research and technology hub, and other relevant initiatives. The present and future links will allow UK to significantly leverage any investment in our consortium and will benefit UK plc. The programme consists of related activities built around the central challenge of flexible and energy efficient (opto)electronics, for which graphene is a unique enabling platform. This will be achieved through four main themes. T1: growth, transfer and printing; T2: energy; T3: connectivity; T4: detectors. The final aim is to develop "graphene-augmented" smart integrated devices on flexible/transparent substrates, with the necessary energy storage capability to work autonomously and wireless connected. Our vision is to take graphene from a state of raw potential to a point where it can revolutionise flexible, wearable and transparent (opto)electronics, with a manifold return for UK, in innovation and exploitation. Graphene has benefits both in terms of cost-advantage, and uniqueness of attributes and performance. It will enable cheap, energy autonomous and disposable devices and communication systems, integrated in transparent and flexible surfaces, with application to smart homes, industrial processes, environmental monitoring, personal healthcare and more. This will lead to ultimate device wearability, new user interfaces and novel interaction paradigms, with new opportunities in communication, gaming, media, social networking, sport and wellness. By enabling flexible (opto)electronics, graphene will allow the exploitation of the existing knowledge base and infrastructure of companies working on organic electronics (organic LEDs, conductive polymers, printable electronics), and a unique synergistic framework for collecting and underpinning many distributed technical competences.

Graphene has many record properties. It is transparent like (or better than) plastic, but conducts heat and electricity better than any metal, it is an elastic thin film, behaves as an impermeable membrane, and it is chemically inert and stable. Thus it is ideal for the production of next generation transparent conductors. Thin and flexible graphene-based electronic components may be obtained and modularly integrated, and thin portable devices may be assembled and distributed. Graphene can withstand dramatic mechanical deformation, for instance it can be folded without breaking. Foldable devices can be imagined, together with a wealth of new form factors, with innovative concepts of integration and distribution. At present, the realisation of an electronic device (such as, e.g., a mobile phone) requires the assembly of a variety of components obtained by many technologies. Graphene, by including different properties within the same material, can offer the opportunity to build a comprehensive technological platform for the realisation of almost any device component, including transistors, batteries, optoelectronic components, photovoltaic cells, (photo)detectors, ultrafast lasers, bio- and physicochemical sensors, etc. Such a change in the paradigm of device manufacturing would revolutionise the global industry. UK will have the chance to re-acquire a prominent position within the global Information and Communication Technology industry, by exploiting the synergy of excellent researchers and manufacturers. Our vision is to take graphene from a state of raw potential to a point where it can revolutionise flexible, wearable and transparent (opto)electronics, with a manifold return for UK, in innovation and exploitation. Graphene has benefits both in terms of cost-advantage, and uniqueness of attributes and performance. It will enable cheap, energy autonomous and disposable devices and communication systems, integrated in transparent and flexible surfaces, with application to smart homes, industrial processes, environmental monitoring, personal healthcare and more. This will lead to ultimate device wearability, new user interfaces and novel interaction paradigms, with new opportunities in communication, gaming, media, social networking, sport and wellness. By enabling flexible (opto)electronics, graphene will allow the exploitation of the existing knowledge base and infrastructure of companies working on organic electronics (organic LEDs, conductive polymers, printable electronics), and a unique synergistic framework for collecting and underpinning many distributed technical competences. The strategic focus of the proposed Cambridge Graphene Centre will be in activities built around the central challenge of flexible and energy efficient (opto)electronics, for which graphene is a unique enabling platform. This will allow us to 1) grow and produce graphene by chemical vapour deposition and liquid phase exfoliation on large scale; 2) prepare and test inks, up to a controlled and closely monitored pilot line. The target is several litres per week of optimized solutions and inks, ready to be provided to present and future partners for testing in their plants; 3) design, test and produce a variety of flexible, antennas, detectors and RF devices based on graphene and related materials, covering all present and future wavelength ranges; 4) prototype and test flexible batteries and supercapacitors and package them for implementation in realistic devices. Our present and future industrial partners will be able to conduct pilot-phase research and device prototyping in this facility, before moving to larger scale testing in realistic industrial settings. Spin-off companies will be incubated, and start-ups will be able to contract their more fundamental work to this facility.

Industrial Biotechnology (IB) is entering a golden age of opportunity. Technological and scientific advances in biotechnology have revolutionised our ability to synthesise molecules of choice, giving access to novel chemistries that enable tuneable selectivity and the use of benign reaction conditions. These developments can now be coupled to advances in the industrialisation of biology to generate innovative manufacturing routes, supported by high throughput and real-time analytics, process automation, artificial intelligence and data-driven science. The current excess energy demands of manufacturing and its use of expensive and resource intensive materials can no longer be tolerated. Impacts on climate change (carbon emissions), societal health (toxic waste streams, pollution) and the environment (depletion of precious resources, waste accumulation) are well documented and unsustainable. What is clear is that a petrochemical-dependent economy cannot support the rate at which we consume goods and the demand we place on cheap and easily accessible materials. The emergent bioeconomy, which fosters resource efficiency and reduced reliance on fossil resources, promises to free society from many of the shortcomings of current manufacturing practices. By harnessing the power of biology through innovative IB, the FBRH will support the development of safer, cleaner and greener manufacturing supply chains. This is at the core of the UKs Clean Growth strategy. The EPSRC Future Biomanufacturing Research Hub (FBRH) will deliver biomanufacturing processes to support the rapid emergence of the bioeconomy and to place the UK at the forefront of global economic Clean Growth in key manufacturing sectors - pharmaceuticals; value-added chemicals; engineering materials. The FBRH will be a biomanufacturing accelerator, coordinating UK academic, HVM catapult, and industrial capabilities to enable the complete biomanufacturing innovation pipeline to deliver economic, robust and scalable bioprocesses to meet societal and commercial demand. The FBRH has developed a clear strategy to achieve this vision. This strategy addresses the need to change the economic reality of biomanufacturing by addressing the entire manufacturing lifecycle, by considering aspects such as scale-up, process intensification, continuous manufacturing, integrated and whole-process modelling. The FBRH will address the urgent need to quickly deliver new biocatalysts, robust industrial hosts and novel production technologies that will enable rapid transition from proof-of-concept to manufacturing at scale. The emphasis is on predictable deployment of sustainable and innovative biomanufacturing technologies through integrated technology development at all scales of production, harnessing UK-wide world-leading research expertise and frontier science and technology, including data-driven AI approaches, automation and new technologies emerging from the 'engineering of biology'. The FBRH will have its Hub at the Manchester Institute of Biotechnology at The University of Manchester, with Spokes at the Innovation and Knowledge Centre for Synthetic Biology (Imperial College London), Advanced Centre for Biochemical Engineering (University College London), the Bioprocess, Environmental and Chemical Technologies Group (Nottingham University), the UK Catalysis Hub (Harwell), the Industrial Biotechnology Innovation Centre (Glasgow) and the Centre for Process Innovation (Wilton). This collaborative approach of linking the UK's leading IB centres that hold complementary expertise together with industry will establish an internationally unique asset for UK manufacturing.

Composites based on continuous fibre prepreg sheet laminates are a mature technology - widely used in the aviation industry for key structural components, However, the future horizon for composite development now lies in providing lightweight thick-section composite parts aimed at replacing metal components predominantly within the automotive sector. High thermal tolerance, thick section composites that are tough and durable could now offer a viable metal replacement technology for an expanding range of sub-chassis applications, particularly wheels, suspension, braking systems gear casings, rotor shrouds and components within the engine compartment. Historically, monolith-type, thick-section parts have typically been made from aluminium or steel, and exceptionally with thermoset composites - but these have fundamental drawbacks when used for thick-section moulding. Thermoplastic discontinuous fibre tapes offer a tantalising alternative to traditional thermosets. Thermoplastic composites (TPC) based on e.g. PEEK and high-performance Nylons have the potential to offer a viable lightweight aluminium replacement option, with superior toughness and fatigue performance - both critical considerations for both automotive and aviation applications. The excellent formability and high flow characteristics mean parts can be produced quickly and cheaply with part counts into the 100,000's, making this class of composites uniquely suited to the volume demanded by the automotive industry, whilst also being capable of being used in thick section mouldings . The recent development of Polyether ether ketone (PEEK) carbon fibre moulding compounds at Exeter showed that this material achieves a bulk modulus of ~40GPa when hot-pressed, which, whilst short of the ~70GPa offered by aluminium, is a marked improvement over previous offerings. Recent advances in manufacturing approach pioneered by the University of Exeter have seen the achievable modulus reliably pushed above 70GPa - directly on par with Aluminium, and, most excitingly, a technique by which controlled, localised orientation might be achieved through the use of pre-consolidated charges, exploiting the high viscosity of the material during manufacture. This technique could revolutionise the TPC sector, allowing the simple manufacture of thick-section components with the optimised design properties previously found only in multiaxial ATL processes. The new "pre-charges" route being proposed, will simplify manufacture, and remove the barriers to rapid volume production, similar to the advent of prepregs and SMC in the 1970's, that made possible the controlled, mass-manufacture of high performance composites in the aviation and automotive industries. A base line improvement in properties together with the removal of manufacturing barriers, could change the current emphasis on thermosets to thermoplastics, which is highly important environmentally. Recycling of most types of thermosets is not commercially viable, despite extensive research into the area. Thermoplastic based systems have the potential to solve the recycling issue, with the ability to melt and re-press components without performance implications greatly improving the recyclability of the material - a characteristic that has long eluded thermoset CFRP's. Moreover, this trait lends itself exceptionally well to in-situ repair and damage healing. The viability of remanufacture and remoulding of composites needs to be established for all of the most common TPC's available. The study will both consider the remanufacture of components (closed loop recycling), and also the viability of 'shape change' with TPC's, i.e. the extent to which materials can be reprocessed like metals through re-melting and reforming multiple times. The future vision is for manufacturers to include recycling/remanufacture instructions as part of standard materials datasheets.