The Government's 'Future of Mobility' and 'Road to Zero' strategies outline a second UK transport revolution, characterised by rapid decarbonisation, increased automation and enhanced connectivity. This radical transformation presents both opportunities and challenges for improving air quality over the next two decades, occurring in the context of disruptive changes in transport technology, increasing public environmental awareness and evolving transport behaviours. In this context, actions taken during the emerging transition phase will influence air pollutant sources and exposure patterns across indoor (i.e. vehicle, rail/bus) and outdoor (i.e. pavement, platform, bus station) land transport environments, with profound future implications for public health. We recognise this critical opportunity for encouraging policy foresight, cultivating scientific advancement and stimulating citizen engagement at the air quality, climate and health nexus. Our vision is to establish a diverse interdisciplinary network, connecting researchers across nine UK higher education and research institutions with >20 network partners, comprising commercial, public sector and non-profit organisations. We will establish sustainable connections to undertake co-definition of issues and opportunities and co-delivery of innovative, evidence-based solutions. We will deliver a varied portfolio of network activities including TRANSITION summits, problem-solving workshops, hackathons, discovery studies, site visits, policy engagement events and creative outreach activities at transport locations. Thus the network partners will achieve the ambitious but achievable goal of directly shaping future air quality, climate and transport policy, reflecting the ambitions of the UKRI SPF Clean Air Analysis and Solutions programme.