Concept: NanoFASE will deliver an integrated Exposure Assessment Framework, including methods, parameter values, model and guidance that will allow Industry to assess the full diversity of industrial nano-enabled products to a standard acceptable in regulatory registrations. Methods to assess how use phases, waste streams and environmental compartments (air, soil, water biota) act as “reactors” in modifying and transporting ENMs will be developed and used to derive parameter values. Our nanospecific models will be integrated with the existing multi-media fate model SimpleBox4Nano for use in EUSES and also develop into a flexible multi-media model for risk assessment at different scales and complexities. Information on release form, transformation and transport processes for product relevant ENMs will allow grouping into Functional Fate Groups according to their “most probable” fate pathways as a contribution to safe-by-design based on fate. Methodology: Inventories of material release forms along the product value chain are established. We then study how released ENMs transform from initial reactive states to modified forms with lower energy states in which nanospecific properties may be lost. Transport studies assess material fluxes within/between compartments. The experimental work underpins models describing ENM transformation and transport. Open access is provided to the models suitable for incorporation into existing exposure assessment tools (e.g. SimpleBox4Nano) and for more detailed assessment. Framework completeness is validated by case studies. Impact: Identified links between ENM material properties and fate outcome (e.g. safe-by-design). Improved representation of nanospecific processes in existing key fate and exposure assessment tools (e.g. SimpleBox4Nano in EUSES). Contribution to standardization. GIS framework to support predictive assessment, catchment and point source management of ENM releases.

Key Enabling Technologies (KET´s) deployment will be the driving force for a significant part of the goods and services that will be available in the market in the next decade. Amongst KET´s, nano-enabled surfaces and membranes must be highlighted due to their huge potential to offer material solutions to address Sustainable Development Goals resulting in positive and sound impacts for the society and key industrial sectors NewSkin aims to create an Open Innovation Test Bed (OITB) to provide the Innovation Ecosystem with the necessary resources and services to uptake a set of game changing, efficient and cost-effective innovative processes to manufacture nano-enabled industrial and consumer products. During the Grant execution the Consortium partners will create an OITB, as well as its structure and procedures establishing a single-entry point, and will validate the OITB capacity to provide services to the I.E executing 165 showcases. After the Grant execution the OITB aims to generate €66.17 million revenues in 5 years creating a €6.7 billion KET market to be absorbed by an end user market of valued at €1 trillion. In 2029, end users markets will obtain economic benefits of about €52.6 billion savings per year mostly devoted to lower energy consumption, increased resources efficiency as well as a reduction of the carbon and volatiles footprint of 184CO2 MT per year and 0.57 MT of VOC’s per year.