Women’s cardiovascular health is an urgent clinical unmet need as reported by the European Society of Cardiology (ESC), as cardiovascular disease (CVD) risk in women still tends to be underestimated by clinicians and women themselves. CVD is under-diagnosed, under-treated and poorly understood, more so in women in the 40-60 age group, when personalised risk assessment and prevention can have a positive impact on their health. In this context, CARAMEL will deliver an innovative personalised prevention model aimed at women 40-60yrs based upon a risk assessment stratification model considering sex and gender specific risk factors and a self-assessment and self-management approach using innovative digital technologies, empowering women to optimise their cardiovascular health. The proposed CVD-Risk Assessment and Stratification scheme will only be possible by the cumulative risk factors analysis, fueled by AI, emerging from a wide number of different data sources, including clinical data from EHR, medical imaging, biomarkers, metabolomics, lifestyle information (sleep, physical activity, diet) from large cohorts and biobanks. A consortium composed by 25 partners and Affiliated Entities coming from 11 countries, composed by 9 clinical entities, 6 research organisations and 10 industry and SMEs will develop, test and validate the personalised prevention program in observational and interventional studies in clinical sites in Colombia, Croatia, Greece, Lithuania and Spain. To that end, engagement of women aged 40-60, will take place from the onset on the co-design and co-creation of the studies and the self-management app ecosystem to be developed. Likewise, Gender in research will be mainstreamed all along the intervention. CARAMEL will also deliver policy recommendation and clinical guidelines supporting the design and update of CVD Plans by health authorities and healthcare providers, considering novel AI based risk models, applicable to women aged 40-60 yrs.

The overall objective of the RETINAL initiative of ULMA Embedded Solutions is to develop non-invasive and cost-effective tools with capacity for prevention and/or early detection of various diseases related to NCD complications, by analyzing the changes in the microvasculature of the retina.The basic framework of RETINAL is a comprehensive solution for ophthalmic imaging analysis and treatment composed of a simple, reliable and cost-effective color fundus digital image capture device and several specific software modules associated to the device for a number of specific clinical applications.The goal of this action is to demonstrate in the market, by independent peers, that RETINAL is the best available and cost-effective technology for the detection of diabetic retinopathy in DR Screening Programmes, and particularly valuable for its implementation at primary health centres, which makes screening more accessible to patients and therefore more effectiveThe overall objective of the RETINAL initiative of ULMA Embedded Solutions is to develop non-invasive and cost-effective tools with capacity for prevention and/or early detection of various diseases related to NCD complications, by analyzing the changes in the microvasculature of the retina.The basic framework of RETINAL is a comprehensive solution for ophthalmic imaging analysis and treatment composed of a simple, reliable and cost-effective color fundus digital image capture device and several specific software modules associated to the device for a number of specific clinical applications.The goal of this action is to demonstrate in the market, by independent peers, that RETINAL is the best available and cost-effective technology for the detection of diabetic retinopathy in DR Screening Programmes, and particularly valuable for its implementation at primary health centres, which makes screening more accessible to patients and therefore more effective

PRODUCTIVE4.0 - AMBITIOUS PROJECT WITH A UNIQUE MAIN OBJECTIVE The main objective of Productive4.0 is to achieve improvement of digitising the European industry by electronics and ICT. Ultimately, the project aims at suitability for everyday application across all industrial sectors – up to TRL8. It addresses various industrial domains with one single approach of digitalisation. What makes the project unique is the holistic system approach of consistently focusing on the three main pillars: digital automation, supply chain networks and product lifecycle management, all of which interact and influence each other. This is part of the new concept of introducing seamless automation and network solutions as well as enhancing the transparency of data, their consistence and overall efficiency. Currently, such a complex project can only be realised in ECSEL. The consortium consists of 45% AENEAS, 30% ARTEMIS-IA, 25% EPOSS partners, thus bringing together all ECSEL communities. Representing over 100 partners from 19 EU and other associated countries, it is a European project, indeed. HANDS-ON SOLUTIONS FOR THE EUROPEAN DIGITAL INDUSTRY • Productive4.0 tackles technological and conceptual approaches in the field of Industry 4.0. The term comprises IIoT (Industrial Internet of Things), CPS (Cyber Physical Systems) and Automation. • The innovation project takes a step further towards hands-on solutions. In the process, practical reference implementations such as 3D printerfarms, customised production or self-learning robot systems will benefit in fields like service-oriented architecture (SOA), IOT components & infrastructures, process virtualisation or standardisation. These fields are addressed in the work packages WP1 through WP6. • In addition to furnishing the industry with tailor-made digital solutions, the Productive4.0 Framework will be provided. • Productive4.0 is a brain pool initiated to strengthen the international leadership of the European industry.

Intelligent Reliability 4.0 (iRel40) has the ultimate goal of improving reliability for electronic components and systems by reducing failure rates along the entire value chain. Trend for system integration, especially for heterogeneous integration, is miniaturization. Thus, reliability becomes an increasing challenge on device and system level and faces exceptional requirements for future complex applications. Applications require customer acceptance and satisfaction at acceptable cost. Reliability must be guaranteed when using systems in new and critical environments. In iRel40, 79 partners from 14 countries collaborate in 6 technical work packages along the value chain. WP1 focuses on specifications and requirements. WP2 and WP3 focus on modelling, simulation, materials and interfaces based on test vehicles. WP4 applies the test vehicle knowledge to industrial pilots related to production. WP5 applies the knowledge to testing. WP6 focuses on application use cases applying the industrial pilots. We assess and validate the iRel40 results. Reliable electronic components and systems are developed faster and new processes are transferred to production with higher speed. Crucial insight gained by Physics of Failure and AI methods will push overall quality levels and reliability. iRel40 results will strengthen production along the value chain and support sustainable success of Electronic Components and Systems investment in Europe. By collaboration between academy, industry and knowledge institutes on this challenging topic of reliability, the project secures more than 25.000 jobs in the 25 participating production and testing sites in Europe. The project supports new applications and reliable chips push applications in energy efficiency, e-mobility, autonomous driving and IoT. This unique project brings, for the first time ever, world-leading reliability experts and European manufacturing expertise together to generate a sustainable pan-European reliability community.

For the purpose of creating digitalisation and automation solutions Arrowhead Tools adresses engineering methodologies and suitable integrated tool chains. With the global aim of substantial reduction of the engineering costs for digitalisation/automation solutions. Thus the Arrowhead Tools vision is: - Engineering processes and tool chains for cost efficient developments of digitalization, connectivity and automation systems solutions in various fields of application For the further and wider commercialisation of automation and digitalisation services and products based on SOA, Arrowhead Framework and similar technologies there is a clear need for engineerings tools that integrates existing automation and digitalisation engineering procedures and tool with SOA based automation/digitalisation technology. For this purpose the Arrowhead Tool’s grand challenges are defined as: - Engineering costs reduction by 40-60% for a wide range of automation/digitalisation solutions. - Tools chains for digitalisation and automation engineering and management, adapted to: 1. existing automation and digitalisation engineering methodologies and tools 2. new IoT and SoS automation and digitalisation engineering and management tools 3. security management tools - Training material and kits for professional engineers The results will create impact on: - Automation and digitalisation solution market - Automation and engineering efficiency and the SSBS market - Automation and digitalisation security - Competence development on engineering of automation and digitalisation solution