The 1938 British Empire Exhibition was a stunning display of architectural achievement and a reflection of the life and culture of Glasgow, the UK and the Commonwealth. The event was of huge international significance and continues to be relevant to the study of British social and industrial history and modernist architecture. In 2006, the British Empire Exhibition, Glasgow 1938 project (run by Glasgow School of Art's Digital Design Studio) produced a well-researched and constructed, photo-real, 3D model of the over 100 principal buildings and structures that comprised the Exhibition together with an accurate 3D map showing the relationship of the various buildings, road and pathways and water features, to the topography of Bellahouston Park. This project also created an archive of related cultural assets and video interviews recording opinions of experts in the fields of architecture and architectural history as well as the recollections of members of the public who attended the Exhibition in 1938. The primary aims of this project, Research Engagement through Virtual Immersive Tools for Learning (REVISIT Learning) are to transform the results of The British Empire Exhibition, Glasgow 1938 into innovative learning tools which are specifically targeted to school-age learners in terms of both age and curriculum, to make these learning tools as widely accessible as possible, and to increase our understanding of the impact of immersive learning tools for teachers and learners through a pilot study. This is a brand new group of users who are highly appropriate to share in the genuinely eye-opening and exciting results from previous British Empire Exhibition research. Existing 3D and 2D digital objects will be highlighted and explored, specifically targeting relevant curriculum areas (including both history and technology) for classes of students who will have the opportunity to not only interactively engage with the learning tools at various pedagogically-robust levels, but to also produce and contribute their own creative responses to the learning tools. This learning methodology not only addresses key curriculum areas (e.g. emphasis on technology skills development) but provides (and, crucially, tests) a creative, non-didactic mode of engaging young learners with 3D research data. Project activities will build on ongoing collaboration with a selection of schools and teachers in order to define the areas of most relevance and educational need. The project outputs are intended to not only fulfil a defined need in education (that is, the creation of 3D immersive learning environments that meaningfully and appropriately engage young learners) but to inspire further learning activities in creative response to the research findings being communicated. REVISIT Learning has a number of major outcomes, with strong implications for pedagogy, cultural interpretation, and creative engagement. The learning tools will not only extend the value and learning opportunities of the original AHRC-funded research to a brand new audience, they will do so in a way that is directly relevant to, and satisfies a clearly expressed need from, the schools. The 3D immersive tools provide teachers and learners with ongoing, free, public access to these learning opportunities - and, importantly, the tools will be editable so can easily be adapted to satisfy the learning outcomes of different age groups and subjects. Adding creative learning activities also allows educators to themselves have a much more creative approach, offering opportunities for school-wide project-based learning and collaboration between different classes of students. The free provision of learning tools through an open, editable delivery system encourages a wide range of continuing uses and will help to embed the use of innovative 3D data-facilitated learning into educational policy and practice, and will also create impact for learners outside the school system.

This project will assess a class of systems that blend electricity generation and storage, to understand the role that they could play in future energy systems. Their ability to deliver low-carbon energy on demand, at low system cost, will be investigated from technical, economic, and policy standpoints. With a growing fraction of electricity consumption being supplied by variable renewable energy sources, the ability to match energy generation and energy consumption is rapidly taking centre stage. Flexible ('dispatchable') coal and gas plants are being displaced to lower carbon emissions. At present, both nuclear and renewable energy technologies are generally configured to generate as much electricity as possible, regardless of the electricity demand at the time. Standalone energy storage, in which surplus electricity is converted to an intermediate energy form and then back again, is emerging as a vital partner to these generation technologies but it is prohibitively expensive for the duties that will be required in the near future. Active management of electricity demand (by shutting down or deferring loads) and electrical interconnections with neighbouring countries will also play important roles but these also have costs and they will not obviate the need for storage. This project will build a deep understanding of a class of system which takes a different and potentially much lower cost approach. These Generation Integrated Energy Storage (GIES) systems, store energy in a convenient form before converting it to electricity on demand. The hypothesis is that the lowest cost and highest performance storage can be achieved by integrating generation and storage within one system. This avoids the expense and inefficiency of transforming primary energy (e.g. wind, solar, nuclear) into electricity, then into an intermediate form, and later back to electricity. For example, the heat produced by a concentrating solar power plant can be stored at far lower cost and with lower losses than producing electricity directly and operating a standalone electricity store. A broad range of opportunities exist for low-carbon GIES systems, in both renewable and nuclear applications. The research team's expertise in wind, nuclear, and liquefied air storage will be applied directly to GIES systems in all three. The project will also establish a framework for the wider significance of GIES to energy systems. Technical and thermodynamic metrics that characterise high performing GIES systems will be developed, and used to compare with standalone generation and storage equivalents. The theoretical groundwork laid by this research will have applications far beyond the current project. Opportunities for current and future technologies will be mapped out and publicised, supporting and accelerating further work in the field. The deployment and operation of such technologies will be modelled by means of a pragmatic real options economic analysis. The unique policy and economic considerations of fusing generation and storage will be reviewed in detail, considering challenges and proposing solutions to regulatory and financial hurdles. Taken in concert, these will determine the value and scope for substantial deployment of GIES systems. In bringing to light the potential of the class of GIES systems, the research team will rectify a gap in energy systems thinking, in time to inform what will be a multi-billion pound expenditure in the coming decade. By providing the tools to analyse and deploy these systems, the research will open up a new avenue for cost-effective flexibility across the energy infrastructure of the UK and other regions worldwide.

Growth factors are molecules within our body that participate in many physiological process that are key during development as they control stem cell function. These molecules thus have the potential to drive the regeneration of tissues in a broad range of medical conditions, including in musculoskeletal (bone repair), haematological (bone marrow transplantation) and cardiovascular (infarction, heart attack) diseases. Growth factors are currently produced commercially and are used regularly in clinical applications. However, they are very power cell signalling molecules and dose is critical as balance between effect and safety has to be considered. To date the use of growth factors in regenerative medicine has been only partially successful and even controversial. The growth factors are rapidly broken down and cleared by the body. This makes prolonged delivery (as is required to effect repair) a problem and typically higher than wanted doses are administered to get around this. While their help in regeneration is undoubted, collateral side effects can be catastrophic e.g. tumour formation. We have developed new technology that directly addresses these concerns as it uses materials (that can be topically implanted) to deliver low, but effective, growth factor doses; this programme is about the safe use of growth factors in clinical applications. This will not only reduce risks for patients who currently receive growth factor treatments, but will open up therapies that can include co-transplantation with stem cells to a wider range of patients as doctors would not have to keep these therapies back for cases of most pressing need. This increased use would minimise costs as growth factors are very expensive and reduced dose would save money per treatment. Our approach is unique and this programme grant will allow us to enhance the UK's world leading position through innovative bioengineering. We know that stem cells have huge regenerative potential and that growth factors provide exquisite stem cell control - both are currently untapped. We will engineer new materials to enable growth factor technology, and critically stem cell technologies, where traditional approaches are falling very short of the mark.

The shift from hunting and gathering to an agricultural way of life was one of the most profound events in the history of our species and one which continues to impact our existence today. Understanding this process is key to understanding the origins and rise of human civilization. Despite decades of study, however, fundamental questions regarding why, where and how it occurred remain largely unanswered. Such a fundamental change in human existence could not have been possible without the domestication of selected animals and plants. The dog is crucial in this story since it was not only the first ever domestic animal, but also the only animal to be domesticated by hunter-gatherers several thousand years before the appearance of farmers. The bones and teeth of early domestic dogs and their wild wolf ancestors hold important clues to our understanding of how, where and when humans and wild animals began the relationship we still depend upon today. These remains have been recovered from as early as 15,000 years ago in numerous archaeological sites across Eurasia suggesting that dogs were either domesticated independently on several occasions across the Old World, or that dogs were domesticated just once and subsequently spreading with late Stone Age hunter gatherers across the Eurasian continent and into North America. There are also those who suggest that wolves were involved in an earlier, failed domestication experiment by Ice Age Palaeolithic hunters about 32,000 years ago. Despite the fact that we generally know the timing and locations of the domestication of all the other farmyard animals, we still know very little for certain about the origins of our most iconic domestic animal. New scientific techniques that include the combination of genetics and statistical analyses of the shapes of ancient bones and teeth are beginning to provide unique insights into the biology of the domestication process itself, as well as new ways of tracking the spread of humans and their domestic animals around the globe. By employing these techniques we will be able to observe the variation that existed in early wolf populations at different levels of biological organization, identify diagnostic signatures that pinpoint which ancestral wolf populations were involved in early dog domestication, reveal the shape (and possibly the genetic) signatures specifically linked to the domestication process and track those signatures through time and space. We have used this combined approach successfully in our previous research enabling us to definitively unravel the complex story of pig domestication in both Europe and the Far East. We have shown that pigs were domesticated multiple times and in multiple places across Eurasia, and the fine-scale resolution of the data we have generated has also allowed us to reveal the migration routes pigs took with early farmers across Europe and into the Pacific. By applying this successful research model to ancient dogs and wolves, we will gain much deeper insight into the fundamental questions that still surround the story of dog domestication.

Over the last 10 years the number of operational satellites in orbit has grown from 450 to more than 1300. We rely on these satellites more than ever before for a wide range of applications such as mobile phones, TV signals, internet, navigation and financial services. All these satellites must be designed to withstand the harsh radiation environment in space for a design life that can be as long as 15 years or more. Space weather events can increase electron radiation levels by five orders of magnitude in the Earth's Van Allen radiation belts causing satellite charging, disruption to satellite operations and sometimes satellite loss. For example, in 2003 it was estimated that at least 10% of all operational satellites suffered anomalies (malfunctions1) during a large space weather event known as the Halloween storm. It is therefore important to understand how and why radiation levels vary so much so that engineers and business can assess impact and develop mitigation measures. New results from the NASA Van Allen Probes and THEMIS satellite missions show that wave-particle interactions play the major role in the acceleration, transport and loss of high energy electrons and hence the variability of the radiation belts. This proposal brings together scientists from across the UK with stakeholders from the insurance and satellite services sector. We will process data from scientific satellites such as Van Allen Probes and THEMIS to obtain information on four very important type of waves known as magnetosonic waves, and radio-waves known as plasmaspheric hiss, lightning generated whistlers and transmitter waves. We will use data, theory and models to determine the properties of the waves and how they vary during space weather events. We will conduct studies to assess the acceleration, transport and loss of electrons due to each wave type using quasi-linear theory. We will use simulations to test whether nonlinear effects result in more particle acceleration and loss compared to quasi-linear theory. We will analyse compressional magnetosonic waves in the ultra-low frequency range and determine their effectiveness for transporting electrons across the magnetic field, and whether the transport is diffusive or not. We will incorporate the results of these studies into our state-of-the-art global radiation belt model to simulate known space weather events, and compare the results against data to highlight the importance of the waves and improve the model. We will also include local time effects and compare loss rates against data from the ground and other satellites to constrain the model. We will simulate extreme space weather events using our existing radiation belt model, and an MHD model so that we can assess the role of waves in the rapid formation of a radiation belt such as occurred in 1991 in less than 2 minutes. We will develop a stakeholder community consisting of space insurance, satellite operators and forecasters who will provide input to our research and who will use the results for risk assessment, anomaly resolution and operational planning. The project will deliver new processed data, a better forecasting capability and expertise that will support the UK Government assessment of severe space weather for the National Risk Register2 and the growth of the satellite industry. 1. Cannon, P, S., et al. (2013), Extreme Space Weather: Impacts on Engineered Systems and Infrastructure, Royal Academy of Engineering, London, SW1A 2WH. 2. Cabinet Office, (2012), National risk register of civil emergencies, Whitehall, London SW1A 2WH, www.cabinetoffice.gov.uk.