Enabling integration of medical and research data, secure data sharing and leveraging responsible state-of-the-art artificial intelligence (AI)-mediated models opens immense possibilities to mitigate the impact of chronic immune-mediated diseases (CIMDs) affecting 10% of Europeans. Eight European universities, leaders in the medical and analytical field, three SMEs, one research institute and one company, at the forefront of clinical AI implementation, data infrastructure, and security, and a Patient Organisation formed the consortium WISDOM. The consortium's overarching aim is to convert complex biological information from the existing data sources into actionable insights. WISDOM builds on the premise that computational tools can provide valuable knowledge and guide decision making at critical stages in the individual patient journey, from diagnosis to treatment initiation and optimisation. To unlock the potential of the existing data, WISDOM will address barriers of data integration and accessibility and deploy novel approaches for data processing, harmonisation, integration, and secure, trustworthy data sharing with federated access. WISDOM aims to develop computational risk stratification and outcome prediction models and tools in different CIMD use cases, building on large EU-funded multimodal datasets, and prospectively validate them on technical, clinical and user aspects to facilitate data-driven and patient-focused diagnosis, treatment, and monitoring. WISDOM aims to promote the widespread utilisation of data and facilitate responsible and critical assessment of the use of AI in healthcare using an end-user guided approach leveraging collaboration among clinicians, researchers, legal and AI experts, patient associations and rich stakeholder expertise. WISDOM’s ultimate ambition is to revolutionise the integration, management, and analysis of health data across diseases and borders to promote personalised interventions and well-being.

Urbane: ONE HEALTH APPROACHES TO SUPPORT AGROECOLOGICAL TRANSFORMATION OF PERI-URBAN FARMING STUDY LINKS BETWEEN FARMING PRACTICES, ANIMAL, HUMAN & ECOSYSTEM HEALTH URBANE will explore the links between farming practices and health as it applies a One Health approach for tackling issues related to the application & intensification of peri-urban agriculture and the health of animals, humans and the ecosystem as a whole. URBANE supports that other than sustainability, applied agroecology allows achievement of better health of humans, animals and the ecosystem in general by promoting improvements in their physical and psycho-emotional states. PROMOTION OF AGROECOLOGICAL FARMING PRACTICES Through sustainable agroecological practices in the peri-urban environment, URBANE aims to make cities more sustainable and inclusive, while boosting the productivity of small-scale food producers located in the peri-urban environment. The project promotes agroecology by building on local knowledge with the support of new technologies and application of the best practices applied in European regions where agroecology is already applied in intensified, market-oriented production fields. DEVELOPMENT OF NOVEL TECHNOLOGIES AND THE URBANE DSS Use of the URBANE novel tools and the engagement of local knowledge will be used as drivers to support decision making and achieve a high impact. URBANE is designed to build on local knowledge, supported by new technologies and best practices applied in European regions where agroecology is already applied in intensified, market-oriented production fields. The URBANE DSS will be delivered in two versions: a) for farmers in the form of a friendly application and b) for authorities providing information on the potential dangers and the environmental and crop yield impact of the application of agroecological farming practices. TRAINING AND POLICY RECOMMENDATIONS Formulation of policy recommendations resulting from the URBANE approach implementation and the project’s results will allow expanding the reach of the approach and positively influence and support of its broader adoption. Policy recommendations will be made for supporting the adoption of the URBANE approach, towards meeting the SDGs, Green Deal and Africa-EU Partnership goals.

Currently, economies worldwide are pursuing mostly a linear model of production which leads to massive material losses, dependency on geopolitically instable states and volatile markets for primary resources. A circular economy, on the contrary, seeks to counter this approach to ?preserve the value of utilized resources and materials as long as possible, to use them as frequently as possible, and to produce as little waste as possible. European industry needs solutions to mitigate the barriers for industrial data reusability and facilitate the unlocking of value from data. Joint Industrial Data Exchange Platform is a place where industrial data is fused for interconnecting seemingly different sectors into the collaboration pipeline. It builds upon the principles of Industry 4.0, by adopting a coherent approach for the semantic communication between diverse actors aimed towards direct or indirect contribution to the EU?s climate neutrality goals of 2050. JIDEP is a landing place to any organization which has any kind of data obstacle to be addressed, on its paths towards delivering more sustainable material, product,service, orsolution. Within JIDEP, built-in tools are made available for unlocking the value of the data, which can lead to the development of more sustainable solutions, technologies, and materials. JIDEP is also an optimizing continuum, covering the entire product lifecycle and steering it towards circular standards implementation at technological and regulatory levels. Finally, JIDEP is a tool equipped with resilience frameworks for growing organizational and industrial capacities to withstand supply chain disruptions in short-, medium- and long-term clauses. As such, JIDEP ingests industrial data and produces sustainability, resilience, and circularity artifacts for its participants.

TWIN2PIPSA will improve R&I capacities of FC.ID/ULisboa (Portugal) in the field of protein folding biophysics and conformational diseases by partnering in joint Twinning activities with three world-leading research and technological development performers: the University of Cambridge (UCAM), the University of Copenhagen (UCPH), and Tel Aviv University (TAU). The folding and misfolding of proteins, their interactions and self-assembly in cells is central to biology and has implications in diseases that affect millions of people worldwide. The so-called conformational diseases include cataracts, metabolic disorders and neurodegenerative pathologies such as Alzheimer’s Disease. Knowledge on the ability to modulate protein interactions and self-assembly is critical to develop applications of protein-based biomaterials like bioadhesive glues or to design therapeutic antibody biologics. TWIN2PIPSA fulfils local needs and will generate outstanding contributions through investigations of pathological self-assembly in vitro and in living cells, nanoscale characterization of protein-based materials and implementation of integrative biomolecular simulations that will raise the international profile and scientific standing of FC.ID/ULisboa. This will enable a local cluster of excellence whose scientific and technological breakthroughs will empower both project partners and the industry sector in their regional innovation ecosystems. The partnership and network will significantly reinforce the R&I capabilities of the widening institution and Portugal’s innovation performance. TWIN2PIPSA comprises several Twinning activities: staff exchanges, secondments to partners, expert visits, meetings, training schools and a joint exploratory project that will translate into biomedical and biotechnological outcomes. Dedicated activities to reinforce research management capacities and administrative skills of FC.ID/ULisboa grant office through mentoring and staff exchanges are also plannedno public description

There is a lack of data, understanding and awareness in Europe and in the world of compound weather and climate extremes. Insufficient governance function also affect the related vulnerability, risk and resilience of people, communities and places. The C2IMPRESS project aims to bring a radical paradigm shift to disaster and hazard research and innovation by moving away from traditional ‘hazard centric’ approach/ framework to a novel ‘place and people’ centred integrated multi-hazard risk and resilient assessment framework. Guided by this framework, the C2IMPRESS project aims to offer an ensemble of innovative revolutionary models, methods, frameworks, tools and technologies that are holistic and robust enough to provide appropriate fine-grained spatio-temporal qualitative and quantitative data, locally appropriate solutions, better prediction with lower uncertainty on risks of single or multiple hazards stemming from extreme weather events like floods, wildfires etc. under different climate change scenarios. Breakthrough innovations from C2IMPRESS project will be System-of-Systems for Multi-Hazard Risk Intelligence Network (SoS4MHRIN) platform (supported by the robust Earth System Dynamic Intelligence (ESDI) and Information Physical Artificial Intelligence (IPAI)), innovative Agent Based Model, polycentric risk governance, multi-actor decision support microservices and a suite of citizen engagement technologies and tools as well as novel co design and co-creation approach for socio-technical innovations, knowledge production and validation to empower citizens and society with climate actions for a sustainable transition to a just risk resilient society. With these social and technical innovations -as novel processes and products- the C2IMPRESS project will provide better understanding and public awareness on multi-hazard risks, the associated multidimensional impacts, vulnerabilities and resilience of extreme weather events in 4 case study areas in Europe.