L-Rhamnose (6-deoxy-L-mannose) is a rare monosaccharide exiting in nature but not easily accessible. It is described as a high value molecule for the food industry, pharmaceuticals, or nutraceuticals due to its unique physiological effects. Regarding a complex and expending market and the existing issues for its actual production (old and non green chemistry, sourcing, purity, etc.) , the methodology (processes) for the next decades must be challenged through (i) an intelligent sourcing, (ii) more up-to-date processing technologies (especially for purification) and (iii) new enzymatic proposals (cocktails, designed enzymes, etc.) for boosting L-Rha production (yield, performance, etc.). RAh is an interdisplinary public partnership that combines approaches in microbiology, biochemistry, physico-chemistry, and process engineering. Its overarching to significantly increase the level of knowledge and proficiency of new sustainable processes for large-scale production of L-Rhamnose. RAh project is directly relevant to the axis H.7 “Bioeconomy, from biomass to uses: chemistry, materials, processes and systemic approaches” of the transversal domain “Ecological and environmental transition” as well as the themes LS_07 “Environmental technology and bioengineering” and LS_11 “Biomass production and utilization, biofuels”. This project will therefore directly support the development and competitiveness of French industry in a strategic domain, integrating important constraints such as carbon, water footprints and the ethical use of natural resources, according to the axis H.7. Adopting an approach based on circular economy and sustainability will also help to support the cross-sectorial approaches and monitor future developments regarding societal and environmental challenges on a 2030 horizon.