In 2023, intracerebral haemorrhage (ICH) remains the most devastating stroke subtype. Evidence suggests that ICH leads to mortality and disability through a combination of primary and secondary (delayed) injury. Perihematomal area is a promising surrogate marker of secondary brain injury after ICH, and a potential therapeutic target. However, neuroradiological definition of the perihematomal area represents an unmet need for improving knowledge on ICH pathophysiological mechanisms and treatments. Perihematomal vessels are likely to be moved over by the mass effect from the hematoma immediately after ICH, with significant mechanical stress and alterations in their density and architecture, and consequent impact in perihematomal brain perfusion, promoting perihaemorrhagic oedema development and contributing to secondary brain injury and poor functional outcome after ICH. In this context, vessel density and architecture changes occurring in the perihematomal area during the acute phase of ICH, and vessel remodeling during brain recovery, have never been studied. The main goal of this project is to characterize vessel density and architectural changes in the perihematomal area and to study their putative association with perihematomal perfusion, perihematomal oedema and patient’s long-term clinical outcome, in a large prospective cohort of patients with ICH. VINCERE-ICH project aims to use a new available computational tool on vessel extraction, segmentation, and analysis for gathering data on perihaemorrhagic area, for studying the association between perihaemorrhagic vessel density and architectural changes and other radiological ICH features, including perihematomal perfusion and perihaemorrhagic oedema, and ICH long-term outcome. This translational project will provide novel insights on novel radiological biomarkers of secondary brain injury, recovery, and functional outcome after ICH, gathering data from a large prospective cohort of patients with acute ICH.