This project aims at investigating how environmental conditions are intrinsically incorporated in the interplay among land uses in urban regions as a two-ways relationship. We argue that the literature is inconclusive on the adequate shape of environmentally friendly cities because the urban internal structure of city is overlooked. We first shed light on environmental attributes across the urban system to identify similar and divergent trends linked to the urban structure. Then, we provide analysis of environmental trade-offs on a sample of urban regions. This proposal is innovative in three respects (i) the knowledge it will provide by linking the internal structure of cities to the heterogeneity in behaviors and to the feedback effect between land uses and urban structure; (ii) the confrontation of cutting edge econometrics and scaling laws viewpoints on cities coming respectively from economics and geography/statistical physics and (iii) the policy recommendations.