The HeriTACE project brings together a transdisciplinary team of research institutes, authorities, SMEs, and industry experienced in design, technology, and policymaking in the domains of conservation, buildings and energy. A significant increase in deep renovations of heritage buildings has the potential to lead to effective energy demand reductions and readiness for the transition to R2ES. Based on prior research and field knowledge supported by various EU and national projects, bottlenecks have been identified that prevent the futureproofing of heritage buildings and its replication. To overcome them, HeriTACE proposes innovative technical solutions, integrated into a holistic and multi-scale renovation approach, by developing and validating: (1) A replicable holistic assessment model and standardised processes to create a holistic vision and plan on the renovation requirements for heritage townhouses in historical neighbourhoods, (2) Optimal and integrated design approaches for the deep renovation of heritage townhouses, with well-considered, targeted and minimal invasive renovation measures, (3) Durable insulation and air tightness solutions for the renovation of building envelopes, respecting their heritage values and traditional building technology, (4) Optimised and smart controlled HVAC-concepts adapted to heritage townhouses, optimising comfort, and indoor air quality precisely where and when the building users need it, and (5) Integrated RES-based energy supply solutions, maximising the share of local RES in heritage buildings within historical neighbourhoods. The project will deliver solutions for authorities and designers to envision and govern a sustainable energy future for heritage townhouses in historical neighbourhoods, thus putting the EU Green Deal and New European Bauhaus into practice. Close collaboration between researchers, SMEs and industry shall increase the availability of high-quality solutions for the building conservation sector.