SOILRES's mission is to improve soil health and crop resilience in response to the declining health of soil ecosystems, largely caused by the overuse of agrochemicals and the impacts of climate change. This will be achieved by promoting sustainable agricultural practices that prioritise biodiversity and the interactions between soil, plants and microorganisms. To achieve these goals, SOILRES will adopt a comprehensive strategy that includes active engagement with stakeholders, the development of agroecological methods, and the implementation of digital tools for effective soil health management. SOILRES will undertake a number of key activities, including the establishment of collaborative co-creation sessions, the development of microbial bioinoculants and biostimulants, and the formulation of best practices tailored to each use case. Field trials will be conducted in six diverse use cases, targeting key agro-climatic regions in Europe (Atlantic (DK), Boreal (FI), Continental (FR), Pannonian (HU) and Mediterranean (IT, PT)), with the objective of validating and refining these interventions. By assessing agronomic, environmental and cost effectiveness, we will identify challenges and opportunities and design optimal strategies for scaling and replicating sustainable practices. SOILRES is aligned with the Missions Programme, which is focused on promoting agricultural sustainability and resilience. It is expected that these outcomes will result in a reduction in the dependence on chemical inputs and an increase in crop productivity. Furthermore, there will be a broader adoption of practices that support biodiversity among farmers. Ultimately, SOILRES aims to strengthen long-term food security and environmental sustainability in Europe by advocating for integrated soil and crop management strategies.