Focused on challenge-driven promotion of healthy living, INTEGER will bring forward three important innovations for the development of more robust, sustainable, inclusive and integrative EU innovation ecosystems: 1.The INTEGER 4 Helix Collaboratory model to implement the next generation of living labs, the ‘Collaboratories’, 2.A EU Healthy Living Collaboratory, a true network of networks’ community with capacity to work on real social, tech and business-driven projects, and 3. A new professional profile, the ‘collaber’ or ‘collaboratory manager’ as a multiplying agent of change of these integrated innovation ecosystems. The 3 INTEGER reinforcing innovations will push fivefold breakthrough capacities for the integration of social innovation in EU innovation ecosystems: 1)Boost win-win games between business and social oriented innovations addressing common challenges. 2)Transform co-creation dynamics into disruptive and tangible new products, services or competencies. 3)Co-design jointly public innovation policies. 4)Develop capacity building of the new generation of socio-digital entrepreneurs and ecosystems’ enablers, the collabers, and 5)Devise funding and investment mechanisms for social innovation start-ups and SMEs to develop and scale up game changing innovations. Collaboratories and collabers aim to embrace economic and social-driven innovation communities across EU. As novel 3H and 4H social-business innovation integration structures, these “labs without walls”, are becoming the common open house of all kinds of innovators and entrepreneurs interested in producing new products and services that come from business or social oriented innovation. Based on a peer-to-peer approach between business-driven and social-driven innovations, INTEGER seeks to accelerate transformative integration outcomes by creating new win-win games, local mission-driven synergies, groundbreaking coordination of actions, governance, implementation, uptaking and exploitation dynamics.