The vision of personalized medicine quickly materializes with increasing computational power employed for delineating the contribution of genetic and lifestyle factors to disease and therapeutic outcomes. However, to help a patient, it is essential to capture a disease status through detailed insight into individuals’ biomedical profile, now enabled thanks to AI-based solutions for big data integration. The access to necessary emerging technologies is currently hampered in many Central-Eastern Europe countries due to an immature culture and insufficient networking of main actors of the R&I sector. The objective of this project is to establish P4Health: a Centre of Excellence for Precise Phenotyping and BioDataBanking, based on the solid foundations of Lukasiewicz-PORT in Wroclaw, Poland. The design of P4Health is rooted in a complementary expertise in preclinical and clinical studies contributed by advanced partners, CERBM (France) and King’s College London (UK). In P4Health, partners will unify existing resources into a coherent workflow combining participatory biobanking, advanced diagnostics, and comprehensive validation of therapeutic strategies in cancer and brain disorders. This synergy will create pillars for new teams to efficiently generate essential data and translate them into economic and societal values. On a scientific level, P4Health will cause structural changes leading to a modernized and more competitive R&I sector in Poland and other Widening countries. On an economic level, P4Health will bring together scientists, clinicians, pharma industry and health case users for creating a forum for knowledge exchange, increased volume of commercialized IP and new business relationships. On a societal level, P4Health will become an expert center for regulatory bodies to support interdisciplinary networks, streamline operations of the health care system, and mobilize the public sector for increased participation in research.