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alphadbs

Adpative DBS
Funder: European CommissionProject code: 190186802 Call for proposal: HORIZON-EIC-2022-ACCELERATOR-01
Funded under: HE | HORIZON-AG Overall Budget: 3,725,440 EURFunder Contribution: 2,500,000 EUR

alphadbs

Description

Differently from other DBS systems on the market, the AlphaDBS can be programmed with two different types of stimulation: conventional DBS, which is implemented also by other DBS systems, and adaptive DBS (aDBS) that automatically adjusts the energy delivered to patient using a biosignal, local field potential (LFP), in a close loop configuration. LFPs represent the synchronous presynaptic and postsynaptic activity of neuronal populations and can be recorded with the macro-electrodes routinely implanted for cDBS. In Parkinson Disease, LFPs (especially in beta-band) are specifically modulated by dopamine intake, movement execution and preparation, and that they encode non-motor functions, such as decision making. The beta band power represents the input variable to the adaptive algorithm, implemented by the AlphaDBS system, which, every second computes a new stimulation value.

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