The AMANDA project aims to stretch the limits of Electronic Smart Systems’ (ESS) autonomy (in terms of energy, decision making & maintenance-free lifetime extension) and miniaturization (by applying high aspect ratio design architecture). Its ultimate goal is to develop and validate a cost-attractive next generation Autonomous Smart Sensing Card (ASSC) that will serve multi-sensorial IoT applications for smart living and working environments. More specifically, AMANDA ambitiously seeks to further strengthen the partners’ technological excellence by delivering the ASSC’s: energy autonomy booster (PV energy harvester, power management electronics and rechargeable storage); connectivity and tracking sub-system; processing unit (built-in intelligence); multi-sensing adaptable sub-system (CO2 sensor, imaging sensor, capacitive sensor, temperature sensor as well as additional off-the-self/ close-to-commercialisation sensors); and the encapsulation & packaging sub-system for high manufacturability. Furthermore, security by design mechanisms will be employed to ensure low vulnerability, user and device authentication, intrusion prevention & detection, and overall enhanced cyber-secure operation. 3 versions of the ASSC are anticipated (indoor, outdoor and wearable) that may be interconnected (swarm capabilities) and managed over the cloud. AMANDA’s ASSC will be validated at versatile use scenarios for applications in the context of smart cities (air quality monitoring through fleets of vehicles and asset tracking and surveillance/ object and people detection), smart homes (indoor air quality and comfort), smart workplaces (indoor comfort, occupancy & productivity) and industrial environments (health, safety and/or environmental monitoring during inspection activities). 8 partners (3 research & 5 industry) from 6 European countries will jointly undertake the proposed research and will deliver the envisaged technological breakthroughs to strengthen European leaderships in ESS.